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Experience of Euclidean geometry sculpts the development and dynamics of rodent hippocampal sequential cell assemblies

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  • Usman Farooq

    (Yale School of Medicine)

  • George Dragoi

    (Yale School of Medicine
    Yale School of Medicine
    Yale University)

Abstract

Euclidean space is the fabric of the world we live in. Whether and how geometric experience shapes our spatial-temporal representations of the world remained unknown. We deprived male rats of experience with crucial features of Euclidean geometry by rearing them inside spheres, and compared activity of large hippocampal neuronal ensembles during navigation and sleep with that of cuboid cage-reared controls. Sphere-rearing from birth permitted emergence of accurate neuronal ensemble spatial codes and preconfigured and plastic time-compressed neuronal sequences. However, sphere-rearing led to diminished individual place cell tuning, more similar neuronal mapping of different track ends/corners, and impaired pattern separation and plasticity of multiple linear tracks, coupled with reduced preconfigured sleep network repertoires. Subsequent experience with multiple linear environments over four days largely reversed these effects. Thus, early-life experience with Euclidean geometry enriches the hippocampal repertoire of preconfigured neuronal patterns selected toward unique representation and discrimination of multiple linear environments.

Suggested Citation

  • Usman Farooq & George Dragoi, 2024. "Experience of Euclidean geometry sculpts the development and dynamics of rodent hippocampal sequential cell assemblies," Nature Communications, Nature, vol. 15(1), pages 1-24, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52758-9
    DOI: 10.1038/s41467-024-52758-9
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    References listed on IDEAS

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    Cited by:

    1. Chenyue Wang & Hongjiang Yang & Shijie Chen & Cheng Wang & Xiaojing Chen, 2024. "Early and late place cells during postnatal development of the hippocampus," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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