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Competitive processes shape multi-synapse plasticity along dendritic segments

Author

Listed:
  • Thomas E. Chater

    (RIKEN Center for Brain Science
    Keio University School of Medicine)

  • Maximilian F. Eggl

    (University of Bonn Medical Center
    CSIC-UMH)

  • Yukiko Goda

    (RIKEN Center for Brain Science
    Okinawa Institute of Science and Technology Graduate University)

  • Tatjana Tchumatchenko

    (University of Bonn Medical Center)

Abstract

Neurons receive thousands of inputs onto their dendritic arbour, where individual synapses undergo activity-dependent plasticity. Long-lasting changes in postsynaptic strengths correlate with changes in spine head volume. The magnitude and direction of such structural plasticity - potentiation (sLTP) and depression (sLTD) - depend upon the number and spatial distribution of stimulated synapses. However, how neurons allocate resources to implement synaptic strength changes across space and time amongst neighbouring synapses remains unclear. Here we combined experimental and modelling approaches to explore the elementary processes underlying multi-spine plasticity. We used glutamate uncaging to induce sLTP at varying number of synapses sharing the same dendritic branch, and we built a model incorporating a dual role Ca2+-dependent component that induces spine growth or shrinkage. Our results suggest that competition among spines for molecular resources is a key driver of multi-spine plasticity and that spatial distance between simultaneously stimulated spines impacts the resulting spine dynamics.

Suggested Citation

  • Thomas E. Chater & Maximilian F. Eggl & Yukiko Goda & Tatjana Tchumatchenko, 2024. "Competitive processes shape multi-synapse plasticity along dendritic segments," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51919-0
    DOI: 10.1038/s41467-024-51919-0
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    References listed on IDEAS

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