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The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases

Author

Listed:
  • Zengliang Jiang

    (Westlake University)

  • Lai-bao Zhuo

    (Sun Yat-sen University)

  • Yan He

    (Southern Medical University
    Southern Medical University)

  • Yuanqing Fu

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine
    Westlake Institute for Advanced Study)

  • Luqi Shen

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine
    Westlake Institute for Advanced Study)

  • Fengzhe Xu

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine)

  • Wanglong Gou

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine)

  • Zelei Miao

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine)

  • Menglei Shuai

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine)

  • Yuhui Liang

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine)

  • Congmei Xiao

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine)

  • Xinxiu Liang

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine)

  • Yunyi Tian

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine)

  • Jiali Wang

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine)

  • Jun Tang

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine
    Westlake Institute for Advanced Study)

  • Kui Deng

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine
    Westlake Institute for Advanced Study)

  • Hongwei Zhou

    (Southern Medical University
    Southern Medical University)

  • Yu-ming Chen

    (Sun Yat-sen University)

  • Ju-Sheng Zheng

    (Westlake University
    Westlake Laboratory of Life Sciences and Biomedicine
    Westlake Institute for Advanced Study)

Abstract

Evidence from human cohorts indicates that chronic insomnia is associated with higher risk of cardiometabolic diseases (CMD), yet whether gut microbiota plays a role is unclear. Here, in a longitudinal cohort (n = 1809), we find that the gut microbiota-bile acid axis may link the positive association between chronic insomnia and CMD. Ruminococcaceae UCG-002 and Ruminococcaceae UCG-003 are the main genera mediating the positive association between chronic insomnia and CMD. These results are also observed in an independent cross-sectional cohort (n = 6122). The inverse associations between those gut microbial biomarkers and CMD are mediated by certain bile acids (isolithocholic acid, muro cholic acid and nor cholic acid). Habitual tea consumption is prospectively associated with the identified gut microbiota and bile acids in an opposite direction compared with chronic insomnia. Our work suggests that microbiota-bile acid axis may be a potential intervention target for reducing the impact of chronic insomnia on cardiometabolic health.

Suggested Citation

  • Zengliang Jiang & Lai-bao Zhuo & Yan He & Yuanqing Fu & Luqi Shen & Fengzhe Xu & Wanglong Gou & Zelei Miao & Menglei Shuai & Yuhui Liang & Congmei Xiao & Xinxiu Liang & Yunyi Tian & Jiali Wang & Jun T, 2022. "The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30712-x
    DOI: 10.1038/s41467-022-30712-x
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