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A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites

Author

Listed:
  • Dylan Dodd

    (Stanford University School of Medicine
    Stanford University School of Medicine)

  • Matthew H. Spitzer

    (Stanford University School of Medicine
    Stanford University School of Medicine
    Helen Diller Family Comprehensive Cancer Center, Parker Institute for Cancer Immunotherapy, University of California, San Francisco)

  • William Van Treuren

    (Stanford University School of Medicine)

  • Bryan D. Merrill

    (Stanford University School of Medicine)

  • Andrew J. Hryckowian

    (Stanford University School of Medicine)

  • Steven K. Higginbottom

    (Stanford University School of Medicine)

  • Anthony Le

    (Stanford University School of Medicine)

  • Tina M. Cowan

    (Stanford University School of Medicine)

  • Garry P. Nolan

    (Stanford University School of Medicine)

  • Michael A. Fischbach

    (University of California, San Francisco
    Stanford University)

  • Justin L. Sonnenburg

    (Stanford University School of Medicine)

Abstract

A pathway for the production of aromatic amino acid metabolites in Clostridium sporogenes is described; modulation of serum levels of these metabolites in gnotobiotic mice affects intestinal permeability and systemic immunity.

Suggested Citation

  • Dylan Dodd & Matthew H. Spitzer & William Van Treuren & Bryan D. Merrill & Andrew J. Hryckowian & Steven K. Higginbottom & Anthony Le & Tina M. Cowan & Garry P. Nolan & Michael A. Fischbach & Justin L, 2017. "A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites," Nature, Nature, vol. 551(7682), pages 648-652, November.
    • Handle: RePEc:nat:nature:v:551:y:2017:i:7682:d:10.1038_nature24661
    DOI: 10.1038/nature24661
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    Citations

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    Cited by:

    1. Hongmiao Wang & Huixun Jia & Yang Gao & Haosong Zhang & Jin Fan & Lijie Zhang & Fandong Ren & Yandong Yin & Yuping Cai & Ji Zhu & Zheng-Jiang Zhu, 2022. "Serum metabolic traits reveal therapeutic toxicities and responses of neoadjuvant chemoradiotherapy in patients with rectal cancer," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Lixiang Zhai & Haitao Xiao & Chengyuan Lin & Hoi Leong Xavier Wong & Yan Y. Lam & Mengxue Gong & Guojun Wu & Ziwan Ning & Chunhua Huang & Yijing Zhang & Chao Yang & Jingyuan Luo & Lu Zhang & Ling Zhao, 2023. "Gut microbiota-derived tryptamine and phenethylamine impair insulin sensitivity in metabolic syndrome and irritable bowel syndrome," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Yunjia Lai & Chih-Wei Liu & Yifei Yang & Yun-Chung Hsiao & Hongyu Ru & Kun Lu, 2021. "High-coverage metabolomics uncovers microbiota-driven biochemical landscape of interorgan transport and gut-brain communication in mice," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    4. Nguyen T. Van & Karen Zhang & Rachel M. Wigmore & Anne I. Kennedy & Carolina R. DaSilva & Jialing Huang & Manju Ambelil & Jose H. Villagomez & Gerald J. O’Connor & Randy S. Longman & Miao Cao & Adam E, 2023. "Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    5. Zengliang Jiang & Lai-bao Zhuo & Yan He & Yuanqing Fu & Luqi Shen & Fengzhe Xu & Wanglong Gou & Zelei Miao & Menglei Shuai & Yuhui Liang & Congmei Xiao & Xinxiu Liang & Yunyi Tian & Jiali Wang & Jun T, 2022. "The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    6. Kali M. Pruss & Haoqing Chen & Yuanyuan Liu & William Treuren & Steven K. Higginbottom & John B. Jarman & Curt R. Fischer & Justin Mak & Beverly Wong & Tina M. Cowan & Michael A. Fischbach & Justin L., 2023. "Host-microbe co-metabolism via MCAD generates circulating metabolites including hippuric acid," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    7. Ethan A. Older & Jian Zhang & Zachary E. Ferris & Dan Xue & Zheng Zhong & Mary K. Mitchell & Michael Madden & Yuzhen Wang & Hexin Chen & Prakash Nagarkatti & Mitzi Nagarkatti & Daping Fan & Melissa El, 2024. "Biosynthetic enzyme analysis identifies a protective role for TLR4-acting gut microbial sulfonolipids in inflammatory bowel disease," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    8. Alice Risely & Kerstin Wilhelm & Tim Clutton-Brock & Marta B. Manser & Simone Sommer, 2021. "Diurnal oscillations in gut bacterial load and composition eclipse seasonal and lifetime dynamics in wild meerkats," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    9. Shanguang Zhao & Selina Khoo & Siew-Cheok Ng & Aiping Chi, 2022. "Brain Functional Network and Amino Acid Metabolism Association in Females with Subclinical Depression," IJERPH, MDPI, vol. 19(6), pages 1-15, March.

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