IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v12y2015i9p11396-11409d55596.html
   My bibliography  Save this article

Impact of Cadmium Exposure on the Association between Lipopolysaccharide and Metabolic Syndrome

Author

Listed:
  • Seung Jin Han

    (Department of Endocrinology and Metabolism, Ajou University School of Medicine, 164, World Cup-ro, Yeongtong-gu, Suwon 443-380, Korea)

  • Kyoung Hwa Ha

    (Department of Endocrinology and Metabolism, Ajou University School of Medicine, 164, World Cup-ro, Yeongtong-gu, Suwon 443-380, Korea
    Cardiovascular and Metabolic Disease Etiology Research Center, Ajou University School of Medicine, 164, World Cup-ro, Yeongtong-gu, Suwon 443-380, Korea)

  • Ja Young Jeon

    (Department of Endocrinology and Metabolism, Ajou University School of Medicine, 164, World Cup-ro, Yeongtong-gu, Suwon 443-380, Korea)

  • Hae Jin Kim

    (Department of Endocrinology and Metabolism, Ajou University School of Medicine, 164, World Cup-ro, Yeongtong-gu, Suwon 443-380, Korea)

  • Kwan Woo Lee

    (Department of Endocrinology and Metabolism, Ajou University School of Medicine, 164, World Cup-ro, Yeongtong-gu, Suwon 443-380, Korea)

  • Dae Jung Kim

    (Department of Endocrinology and Metabolism, Ajou University School of Medicine, 164, World Cup-ro, Yeongtong-gu, Suwon 443-380, Korea
    Cardiovascular and Metabolic Disease Etiology Research Center, Ajou University School of Medicine, 164, World Cup-ro, Yeongtong-gu, Suwon 443-380, Korea)

Abstract

Cadmium (Cd) is an environmental contaminant that has a direct impact on the gut microbiome. Perturbations in the gut microbiome have been linked to metabolic disorders associated with inflammation generated by lipopolysaccharide (LPS). We investigated the impact of Cd on the association between LPS and metabolic syndrome. The study population consisted of 200 apparently healthy subjects (30–64 years of age; 96 men, 104 women). Serum LPS and blood Cd concentrations were measured by ELISA and graphite furnace-atomic absorption spectrophotometry (GF-AAS), respectively. The highest LPS quartile was associated with a greater prevalence of metabolic syndrome in men. There was a significant association between LPS activity and metabolic syndrome in men with blood Cd concentrations higher than the 50th percentile (OR = 3.05, 95% CI = 1.39–6.70); however, this relationship was not significant in men with blood Cd concentrations lower than the 50th percentile. The results of this study provide evidence for a strong association between high LPS activity and the prevalence of metabolic syndrome in men with relatively high blood Cd concentrations. Therefore, exposure to Cd may potentiate the association between LPS and metabolic syndrome in men.

Suggested Citation

  • Seung Jin Han & Kyoung Hwa Ha & Ja Young Jeon & Hae Jin Kim & Kwan Woo Lee & Dae Jung Kim, 2015. "Impact of Cadmium Exposure on the Association between Lipopolysaccharide and Metabolic Syndrome," IJERPH, MDPI, vol. 12(9), pages 1-14, September.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:9:p:11396-11409:d:55596
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/12/9/11396/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/12/9/11396/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Fredrik H. Karlsson & Valentina Tremaroli & Intawat Nookaew & Göran Bergström & Carl Johan Behre & Björn Fagerberg & Jens Nielsen & Fredrik Bäckhed, 2013. "Gut metagenome in European women with normal, impaired and diabetic glucose control," Nature, Nature, vol. 498(7452), pages 99-103, June.
    2. Junjie Qin & Yingrui Li & Zhiming Cai & Shenghui Li & Jianfeng Zhu & Fan Zhang & Suisha Liang & Wenwei Zhang & Yuanlin Guan & Dongqian Shen & Yangqing Peng & Dongya Zhang & Zhuye Jie & Wenxian Wu & Yo, 2012. "A metagenome-wide association study of gut microbiota in type 2 diabetes," Nature, Nature, vol. 490(7418), pages 55-60, October.
    3. Ruth E. Ley & Peter J. Turnbaugh & Samuel Klein & Jeffrey I. Gordon, 2006. "Human gut microbes associated with obesity," Nature, Nature, vol. 444(7122), pages 1022-1023, December.
    4. Gökhan S. Hotamisligil, 2006. "Inflammation and metabolic disorders," Nature, Nature, vol. 444(7121), pages 860-867, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Zahraa Al Bander & Marloes Dekker Nitert & Aya Mousa & Negar Naderpoor, 2020. "The Gut Microbiota and Inflammation: An Overview," IJERPH, MDPI, vol. 17(20), pages 1-21, October.
    2. Maja Czerwińska-Rogowska & Karolina Skonieczna-Żydecka & Krzysztof Kaseja & Karolina Jakubczyk & Joanna Palma & Marta Bott-Olejnik & Sławomir Brzozowski & Ewa Stachowska, 2022. "Kitchen Diet vs. Industrial Diets—Impact on Intestinal Barrier Parameters among Stroke Patients," IJERPH, MDPI, vol. 19(10), pages 1-11, May.
    3. Jim Parker & Claire O’Brien & Jason Hawrelak & Felice L. Gersh, 2022. "Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment," IJERPH, MDPI, vol. 19(3), pages 1-25, January.
    4. Edoardo Pasolli & Duy Tin Truong & Faizan Malik & Levi Waldron & Nicola Segata, 2016. "Machine Learning Meta-analysis of Large Metagenomic Datasets: Tools and Biological Insights," PLOS Computational Biology, Public Library of Science, vol. 12(7), pages 1-26, July.
    5. Zengliang Jiang & Lai-bao Zhuo & Yan He & Yuanqing Fu & Luqi Shen & Fengzhe Xu & Wanglong Gou & Zelei Miao & Menglei Shuai & Yuhui Liang & Congmei Xiao & Xinxiu Liang & Yunyi Tian & Jiali Wang & Jun T, 2022. "The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    6. Feng Tong & Teng Wang & Na L. Gao & Ziying Liu & Kuiqing Cui & Yiqian Duan & Sicheng Wu & Yuhong Luo & Zhipeng Li & Chengjian Yang & Yixue Xu & Bo Lin & Liguo Yang & Alfredo Pauciullo & Deshun Shi & G, 2022. "The microbiome of the buffalo digestive tract," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    7. Koji Hosomi & Mayu Saito & Jonguk Park & Haruka Murakami & Naoko Shibata & Masahiro Ando & Takahiro Nagatake & Kana Konishi & Harumi Ohno & Kumpei Tanisawa & Attayeb Mohsen & Yi-An Chen & Hitoshi Kawa, 2022. "Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    8. Xiaoxiao Yuan & Ruirui Wang & Bing Han & ChengJun Sun & Ruimin Chen & Haiyan Wei & Linqi Chen & Hongwei Du & Guimei Li & Yu Yang & Xiaojuan Chen & Lanwei Cui & Zhenran Xu & Junfen Fu & Jin Wu & Wei Gu, 2022. "Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    9. Dongyang Yang & Wei Xu, 2023. "Estimation of Mediation Effect on Zero-Inflated Microbiome Mediators," Mathematics, MDPI, vol. 11(13), pages 1-16, June.
    10. Aibo Gao & Junlei Su & Ruixin Liu & Shaoqian Zhao & Wen Li & Xiaoqiang Xu & Danjie Li & Juan Shi & Bin Gu & Juan Zhang & Qi Li & Xiaolin Wang & Yifei Zhang & Yu Xu & Jieli Lu & Guang Ning & Jie Hong &, 2021. "Sexual dimorphism in glucose metabolism is shaped by androgen-driven gut microbiome," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    11. Alessandra N. Bazzano & Kaitlin S. Potts & Lydia A. Bazzano & John B. Mason, 2017. "The Life Course Implications of Ready to Use Therapeutic Food for Children in Low-Income Countries," IJERPH, MDPI, vol. 14(4), pages 1-19, April.
    12. Eryun Zhang & Lihua Jin & Yangmeng Wang & Jui Tu & Ruirong Zheng & Lili Ding & Zhipeng Fang & Mingjie Fan & Ismail Al-Abdullah & Rama Natarajan & Ke Ma & Zhengtao Wang & Arthur D. Riggs & Sarah C. Shu, 2022. "Intestinal AMPK modulation of microbiota mediates crosstalk with brown fat to control thermogenesis," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    13. Qian Zhang & Lijuan Zhang & Yang Lyu & Yutao Shi & Liangyun Zhu & Min Zhang & Yuyan Zhao & Di Zhao & Lei Wang & Dan Yi & Yongqing Hou & Tao Wu, 2022. "Dietary supplementation of Lactobacillus zeae regulated the gut microbiome in piglets infected with enterotoxigenic Escherichia coli," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 67(1), pages 27-38.
    14. Farman, Muhammad & Ahmad, Aqeel & Zehra, Anum & Nisar, Kottakkaran Sooppy & Hincal, Evren & Akgul, Ali, 2024. "Analysis and controllability of diabetes model for experimental data by using fractional operator," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 218(C), pages 133-148.
    15. Kiran Konain & Sadia & Turfa Nadeem & Adeed Khan & Warda Iqbal & Arsalan & Amir Javed & Ruby Khan & Kainat Jamil & Kainat Jamil, 2018. "Importance of Probiotics in Gastrointestinal Tract," Journal of Asian Scientific Research, Asian Economic and Social Society, vol. 8(3), pages 128-143, March.
    16. Hai-Hua Chuang & Rong-Ho Lin & Wen-Cheng Li & Wei-Chung Yeh & Yen-An Lin & Jau-Yuan Chen, 2020. "High-Sensitivity C-Reactive Protein Elevation Is Independently Associated with Subclinical Renal Impairment in the Middle-Aged and Elderly Population—A Community-Based Study in Northern Taiwan," IJERPH, MDPI, vol. 17(16), pages 1-10, August.
    17. Pirjo Wacklin & Harri Mäkivuokko & Noora Alakulppi & Janne Nikkilä & Heli Tenkanen & Jarkko Räbinä & Jukka Partanen & Kari Aranko & Jaana Mättö, 2011. "Secretor Genotype (FUT2 gene) Is Strongly Associated with the Composition of Bifidobacteria in the Human Intestine," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-10, May.
    18. Piontak, Joy Rayanne & Russell, Michael A. & Danese, Andrea & Copeland, William E. & Hoyle, Rick H. & Odgers, Candice L., 2017. "Violence exposure and adolescents' same-day obesogenic behaviors: New findings and a replication," Social Science & Medicine, Elsevier, vol. 189(C), pages 145-151.
    19. Jaime Gomez-Ramirez, 2012. "Inverse Thinking in Economic Theory: A Radical Approach to Economic Thinking," Papers 1208.3460, arXiv.org.
    20. Frisha Abkar & Sajjad ur Rahman & Ahsan Naveed & Hira Rasheed & Syed Ashar Mehfooz, 2019. "Evaluation of Oral Microflora in Obese and Non- Obese Humans from District Faisalabad, Pakistan," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 10(1), pages 12-16, March.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:12:y:2015:i:9:p:11396-11409:d:55596. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.