IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v535y2016i7610d10.1038_nature18846.html
   My bibliography  Save this article

Diet–microbiota interactions as moderators of human metabolism

Author

Listed:
  • Justin L. Sonnenburg

    (Stanford University School of Medicine)

  • Fredrik Bäckhed

    (Wallenberg Laboratory for Cardiovascular and Metabolic Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
    Section for Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen)

Abstract

It is widely accepted that obesity and associated metabolic diseases, including type 2 diabetes, are intimately linked to diet. However, the gut microbiota has also become a focus for research at the intersection of diet and metabolic health. Mechanisms that link the gut microbiota with obesity are coming to light through a powerful combination of translation-focused animal models and studies in humans. A body of knowledge is accumulating that points to the gut microbiota as a mediator of dietary impact on the host metabolic status. Efforts are focusing on the establishment of causal relationships in people and the prospect of therapeutic interventions such as personalized nutrition.

Suggested Citation

  • Justin L. Sonnenburg & Fredrik Bäckhed, 2016. "Diet–microbiota interactions as moderators of human metabolism," Nature, Nature, vol. 535(7610), pages 56-64, July.
    • Handle: RePEc:nat:nature:v:535:y:2016:i:7610:d:10.1038_nature18846
    DOI: 10.1038/nature18846
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature18846
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature18846?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Vilma Viliene & Asta Raceviciute-Stupeliene & Saulius Bliznikas & Alius Pockevicius & Monika Nutautaite & Vilma Sasyte, 2022. "The impact of different inclusion levels of whole barley in feed on growth performance, carcass, and gastrointestinal traits of broiler chickens," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 67(4), pages 147-156.
    2. Karolina Skonieczna-Żydecka & Ewa Stachowska & Dominika Maciejewska & Karina Ryterska & Joanna Palma & Maja Czerwińska-Rogowska & Mariusz Kaczmarczyk & Anna Gudan & Honorata Mruk & Barbara Świniarska , 2018. "The Digestive Health among Participants of the Woodstock Rock Festival in Poland—A Cross-Sectional Survey," IJERPH, MDPI, vol. 15(10), pages 1-13, October.
    3. Zengliang Jiang & Lai-bao Zhuo & Yan He & Yuanqing Fu & Luqi Shen & Fengzhe Xu & Wanglong Gou & Zelei Miao & Menglei Shuai & Yuhui Liang & Congmei Xiao & Xinxiu Liang & Yunyi Tian & Jiali Wang & Jun T, 2022. "The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    4. Shao-Ming Gao & Han-Lan Fei & Qi Li & Li-Ying Lan & Li-Nan Huang & Peng-Fei Fan, 2024. "Eco-evolutionary dynamics of gut phageome in wild gibbons (Hoolock tianxing) with seasonal diet variations," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    5. Gertrude Ecklu-Mensah & Candice Choo-Kang & Maria Gjerstad Maseng & Sonya Donato & Pascal Bovet & Bharathi Viswanathan & Kweku Bedu-Addo & Jacob Plange-Rhule & Prince Oti Boateng & Terrence E. Forrest, 2023. "Gut microbiota and fecal short chain fatty acids differ with adiposity and country of origin: the METS-microbiome study," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    6. Lucía Guadamuro & M. Andrea Azcárate-Peril & Rafael Tojo & Baltasar Mayo & Susana Delgado, 2021. "Impact of Dietary Isoflavone Supplementation on the Fecal Microbiota and Its Metabolites in Postmenopausal Women," IJERPH, MDPI, vol. 18(15), pages 1-11, July.
    7. Noemi Boqué & Lucía Tarro & Alice Rosi & Helena Torrell & Guillermo Saldaña & Elisa Luengo & Zeev Rachman & António Pires & Nuno Tiago Tavares & Ana Salomé Pires & Maria Filomena Botelho & Pedro Mena , 2021. "Study Protocol of a Multicenter Randomized Controlled Trial to Tackle Obesity through a Mediterranean Diet vs. a Traditional Low-Fat Diet in Adolescents: The MED4Youth Study," IJERPH, MDPI, vol. 18(9), pages 1-16, May.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:535:y:2016:i:7610:d:10.1038_nature18846. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.