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Gut metagenome in European women with normal, impaired and diabetic glucose control

Author

Listed:
  • Fredrik H. Karlsson

    (Chalmers University of Technology, SE-412 96 Gothenburg, Sweden)

  • Valentina Tremaroli

    (The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Institute of Medicine, University of Gothenburg, SE-413 45 Gothenburg, Sweden)

  • Intawat Nookaew

    (Chalmers University of Technology, SE-412 96 Gothenburg, Sweden)

  • Göran Bergström

    (The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Institute of Medicine, University of Gothenburg, SE-413 45 Gothenburg, Sweden)

  • Carl Johan Behre

    (The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Institute of Medicine, University of Gothenburg, SE-413 45 Gothenburg, Sweden)

  • Björn Fagerberg

    (The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Institute of Medicine, University of Gothenburg, SE-413 45 Gothenburg, Sweden)

  • Jens Nielsen

    (Chalmers University of Technology, SE-412 96 Gothenburg, Sweden)

  • Fredrik Bäckhed

    (The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Institute of Medicine, University of Gothenburg, SE-413 45 Gothenburg, Sweden
    Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark)

Abstract

The faecal metagenome of a cohort of 145 European women with normal, impaired or diabetic glucose control was characterized and discriminant metagenomic markers for type 2 diabetes were identified; the discriminant markers differed from those of a recent Chinese cohort, suggesting that metagenomic predictive tools may need to be specific for age and geographic location.

Suggested Citation

  • Fredrik H. Karlsson & Valentina Tremaroli & Intawat Nookaew & Göran Bergström & Carl Johan Behre & Björn Fagerberg & Jens Nielsen & Fredrik Bäckhed, 2013. "Gut metagenome in European women with normal, impaired and diabetic glucose control," Nature, Nature, vol. 498(7452), pages 99-103, June.
    • Handle: RePEc:nat:nature:v:498:y:2013:i:7452:d:10.1038_nature12198
    DOI: 10.1038/nature12198
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    2. Koji Hosomi & Mayu Saito & Jonguk Park & Haruka Murakami & Naoko Shibata & Masahiro Ando & Takahiro Nagatake & Kana Konishi & Harumi Ohno & Kumpei Tanisawa & Attayeb Mohsen & Yi-An Chen & Hitoshi Kawa, 2022. "Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Xiaoxiao Yuan & Ruirui Wang & Bing Han & ChengJun Sun & Ruimin Chen & Haiyan Wei & Linqi Chen & Hongwei Du & Guimei Li & Yu Yang & Xiaojuan Chen & Lanwei Cui & Zhenran Xu & Junfen Fu & Jin Wu & Wei Gu, 2022. "Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    4. Zahraa Al Bander & Marloes Dekker Nitert & Aya Mousa & Negar Naderpoor, 2020. "The Gut Microbiota and Inflammation: An Overview," IJERPH, MDPI, vol. 17(20), pages 1-21, October.
    5. Lihua Cai & Honglong Wu & Dongfang Li & Ke Zhou & Fuhao Zou, 2015. "Type 2 Diabetes Biomarkers of Human Gut Microbiota Selected via Iterative Sure Independent Screening Method," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-15, October.
    6. Mile Volarić & Dunja Šojat & Ljiljana Trtica Majnarić & Domagoj Vučić, 2024. "The Association between Functional Dyspepsia and Metabolic Syndrome—The State of the Art," IJERPH, MDPI, vol. 21(2), pages 1-19, February.
    7. Konstantin Shestopaloff & Mei Dong & Fan Gao & Wei Xu, 2021. "Dcmd: Distance-based classification using mixture distributions on microbiome data," PLOS Computational Biology, Public Library of Science, vol. 17(3), pages 1-18, March.
    8. Alessandra N. Bazzano & Kaitlin S. Potts & Lydia A. Bazzano & John B. Mason, 2017. "The Life Course Implications of Ready to Use Therapeutic Food for Children in Low-Income Countries," IJERPH, MDPI, vol. 14(4), pages 1-19, April.
    9. Jim Parker & Claire O’Brien & Jason Hawrelak & Felice L. Gersh, 2022. "Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment," IJERPH, MDPI, vol. 19(3), pages 1-25, January.
    10. Eryun Zhang & Lihua Jin & Yangmeng Wang & Jui Tu & Ruirong Zheng & Lili Ding & Zhipeng Fang & Mingjie Fan & Ismail Al-Abdullah & Rama Natarajan & Ke Ma & Zhengtao Wang & Arthur D. Riggs & Sarah C. Shu, 2022. "Intestinal AMPK modulation of microbiota mediates crosstalk with brown fat to control thermogenesis," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    11. Li-Min Chuang & Wei-Jen Chen & Min-Tsai Lai, 2019. "Standardization for innovation: The adoption of drug entity identification in the pharmaceutical industry for public health," Advances in Management and Applied Economics, SCIENPRESS Ltd, vol. 9(4), pages 1-4.
    12. Edoardo Pasolli & Duy Tin Truong & Faizan Malik & Levi Waldron & Nicola Segata, 2016. "Machine Learning Meta-analysis of Large Metagenomic Datasets: Tools and Biological Insights," PLOS Computational Biology, Public Library of Science, vol. 12(7), pages 1-26, July.
    13. Lena Takayasu & Wataru Suda & Eiichiro Watanabe & Shinji Fukuda & Kageyasu Takanashi & Hiroshi Ohno & Misako Takayasu & Hideki Takayasu & Masahira Hattori, 2017. "A 3-dimensional mathematical model of microbial proliferation that generates the characteristic cumulative relative abundance distributions in gut microbiomes," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-20, August.
    14. Manal A. Tashkandi & Rewaa S. Jalal & Lina Baz & Mohammed Y. Refai & Ashwag Shami & Ruba Abdulrahman Ashy & Haneen W. Abuauf & Fatimah M. Alshehrei & Fawzia A. Alshubaily & Aminah A. Barqawi & Sahar A, 2022. "Functional Interpretation of Cross-Talking Pathways with Emphasis on Amino Acid Metabolism in Rhizosphere Microbiome of the Wild Plant Moringa oleifera," Agriculture, MDPI, vol. 12(11), pages 1-22, October.
    15. Zengliang Jiang & Lai-bao Zhuo & Yan He & Yuanqing Fu & Luqi Shen & Fengzhe Xu & Wanglong Gou & Zelei Miao & Menglei Shuai & Yuhui Liang & Congmei Xiao & Xinxiu Liang & Yunyi Tian & Jiali Wang & Jun T, 2022. "The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    16. Alexandria Turner & Martin Veysey & Simon Keely & Christopher J. Scarlett & Mark Lucock & Emma L. Beckett, 2020. "Intense Sweeteners, Taste Receptors and the Gut Microbiome: A Metabolic Health Perspective," IJERPH, MDPI, vol. 17(11), pages 1-18, June.
    17. Seung Jin Han & Kyoung Hwa Ha & Ja Young Jeon & Hae Jin Kim & Kwan Woo Lee & Dae Jung Kim, 2015. "Impact of Cadmium Exposure on the Association between Lipopolysaccharide and Metabolic Syndrome," IJERPH, MDPI, vol. 12(9), pages 1-14, September.

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