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Relationship between gut microbiota and circulating metabolites in population-based cohorts

Author

Listed:
  • Dina Vojinovic

    (University Medical Center)

  • Djawad Radjabzadeh

    (University Medical Center)

  • Alexander Kurilshikov

    (University of Groningen, University Medical Center Groningen, Department of Genetics)

  • Najaf Amin

    (University Medical Center)

  • Cisca Wijmenga

    (University of Groningen, University Medical Center Groningen, Department of Genetics)

  • Lude Franke

    (University of Groningen, University Medical Center Groningen, Department of Genetics)

  • M. Arfan Ikram

    (University Medical Center)

  • Andre G. Uitterlinden

    (University Medical Center
    University Medical Center)

  • Alexandra Zhernakova

    (University of Groningen, University Medical Center Groningen, Department of Genetics)

  • Jingyuan Fu

    (University of Groningen, University Medical Center Groningen, Department of Genetics
    University of Groningen and University Medical Center Groningen)

  • Robert Kraaij

    (University Medical Center)

  • Cornelia M. van Duijn

    (University Medical Center
    University of Oxford)

Abstract

Gut microbiota has been implicated in major diseases affecting the human population and has also been linked to triglycerides and high-density lipoprotein levels in the circulation. Recent development in metabolomics allows classifying the lipoprotein particles into more details. Here, we examine the impact of gut microbiota on circulating metabolites measured by Nuclear Magnetic Resonance technology in 2309 individuals from the Rotterdam Study and the LifeLines-DEEP cohort. We assess the relationship between gut microbiota and metabolites by linear regression analysis while adjusting for age, sex, body-mass index, technical covariates, medication use, and multiple testing. We report an association of 32 microbial families and genera with very-low-density and high-density subfractions, serum lipid measures, glycolysis-related metabolites, ketone bodies, amino acids, and acute-phase reaction markers. These observations provide insights into the role of microbiota in host metabolism and support the potential of gut microbiota as a target for therapeutic and preventive interventions.

Suggested Citation

  • Dina Vojinovic & Djawad Radjabzadeh & Alexander Kurilshikov & Najaf Amin & Cisca Wijmenga & Lude Franke & M. Arfan Ikram & Andre G. Uitterlinden & Alexandra Zhernakova & Jingyuan Fu & Robert Kraaij & , 2019. "Relationship between gut microbiota and circulating metabolites in population-based cohorts," Nature Communications, Nature, vol. 10(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13721-1
    DOI: 10.1038/s41467-019-13721-1
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    Cited by:

    1. Koen F. Dekkers & Sergi Sayols-Baixeras & Gabriel Baldanzi & Christoph Nowak & Ulf Hammar & Diem Nguyen & Georgios Varotsis & Louise Brunkwall & Nynne Nielsen & Aron C. Eklund & Jacob Bak Holm & H. Bj, 2022. "An online atlas of human plasma metabolite signatures of gut microbiome composition," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Zengliang Jiang & Lai-bao Zhuo & Yan He & Yuanqing Fu & Luqi Shen & Fengzhe Xu & Wanglong Gou & Zelei Miao & Menglei Shuai & Yuhui Liang & Congmei Xiao & Xinxiu Liang & Yunyi Tian & Jiali Wang & Jun T, 2022. "The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Kui Deng & Jin-jian Xu & Luqi Shen & Hui Zhao & Wanglong Gou & Fengzhe Xu & Yuanqing Fu & Zengliang Jiang & Menglei Shuai & Bang-yan Li & Wei Hu & Ju-Sheng Zheng & Yu-ming Chen, 2023. "Comparison of fecal and blood metabolome reveals inconsistent associations of the gut microbiota with cardiometabolic diseases," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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