IDEAS home Printed from https://ideas.repec.org/a/gam/jsusta/v13y2021i10p5653-d557062.html
   My bibliography  Save this article

Genetic Technologies for Sustainable Management of Insect Pests and Disease Vectors

Author

Listed:
  • Silvia Grilli

    (Department of Life Sciences, Imperial College London, London SW7 2AZ, UK)

  • Roberto Galizi

    (Centre for Applied Entomology and Parasitology, School of Life Sciences, Keele University, Staffordshire ST5 5GB, UK)

  • Chrysanthi Taxiarchi

    (Department of Life Sciences, Imperial College London, London SW7 2AZ, UK)

Abstract

Recent advancements in genetic and genome editing research, augmented by the discovery of new molecular tools such as CRISPR, have revolutionised the field of genetic engineering by enabling precise site-specific genome modifications with unprecedented ease. These technologies have found a vast range of applications, including the development of novel methods for the control of vector and pest insects. According to their genetic makeup and engineering, these tools can be tuned to impose different grades of impact on the targeted populations. Here, we review some of the most recent genetic control innovations under development, describing their molecular mechanisms and performance, highlighting the sustainability potentials of such interventions.

Suggested Citation

  • Silvia Grilli & Roberto Galizi & Chrysanthi Taxiarchi, 2021. "Genetic Technologies for Sustainable Management of Insect Pests and Disease Vectors," Sustainability, MDPI, vol. 13(10), pages 1-19, May.
    • Handle: RePEc:gam:jsusta:v:13:y:2021:i:10:p:5653-:d:557062
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/2071-1050/13/10/5653/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/2071-1050/13/10/5653/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Jackson Champer & Esther Lee & Emily Yang & Chen Liu & Andrew G. Clark & Philipp W. Messer, 2020. "A toxin-antidote CRISPR gene drive system for regional population modification," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    2. Jackie L. Shane & Christina L. Grogan & Caroline Cwalina & David J. Lampe, 2018. "Blood meal-induced inhibition of vector-borne disease by transgenic microbiota," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    3. Emily Waltz, 2021. "First genetically modified mosquitoes released in the United States," Nature, Nature, vol. 593(7858), pages 175-176, May.
    4. Nikolai Windbichler & Miriam Menichelli & Philippos Aris Papathanos & Summer B. Thyme & Hui Li & Umut Y. Ulge & Blake T. Hovde & David Baker & Raymond J. Monnat & Austin Burt & Andrea Crisanti, 2011. "A synthetic homing endonuclease-based gene drive system in the human malaria mosquito," Nature, Nature, vol. 473(7346), pages 212-215, May.
    5. Beaghton, Andrea & Beaghton, Pantelis John & Burt, Austin, 2016. "Gene drive through a landscape: Reaction–diffusion models of population suppression and elimination by a sex ratio distorter," Theoretical Population Biology, Elsevier, vol. 108(C), pages 51-69.
    6. Adriana Adolfi & Valentino M. Gantz & Nijole Jasinskiene & Hsu-Feng Lee & Kristy Hwang & Gerard Terradas & Emily A. Bulger & Arunachalam Ramaiah & Jared B. Bennett & J. J. Emerson & John M. Marshall &, 2020. "Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    7. Nikolay P. Kandul & Junru Liu & Hector M. Sanchez C. & Sean L. Wu & John M. Marshall & Omar S. Akbari, 2019. "Transforming insect population control with precision guided sterile males with demonstration in flies," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    8. Roberto Galizi & Lindsey A. Doyle & Miriam Menichelli & Federica Bernardini & Anne Deredec & Austin Burt & Barry L. Stoddard & Nikolai Windbichler & Andrea Crisanti, 2014. "A synthetic sex ratio distortion system for the control of the human malaria mosquito," Nature Communications, Nature, vol. 5(1), pages 1-8, September.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Sebald A. N. Verkuijl & Estela Gonzalez & Ming Li & Joshua X. D. Ang & Nikolay P. Kandul & Michelle A. E. Anderson & Omar S. Akbari & Michael B. Bonsall & Luke Alphey, 2022. "A CRISPR endonuclease gene drive reveals distinct mechanisms of inheritance bias," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Beaghton, P.J. & Burt, Austin, 2022. "Gene drives and population persistence vs elimination: The impact of spatial structure and inbreeding at low density," Theoretical Population Biology, Elsevier, vol. 145(C), pages 109-125.
    3. Stephanie Gamez & Duverney Chaverra-Rodriguez & Anna Buchman & Nikolay P. Kandul & Stelia C. Mendez-Sanchez & Jared B. Bennett & Héctor M. Sánchez C. & Ting Yang & Igor Antoshechkin & Jonny E. Duque &, 2021. "Exploiting a Y chromosome-linked Cas9 for sex selection and gene drive," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    4. Angela Meccariello & Shibo Hou & Serafima Davydova & James Daniel Fawcett & Alexandra Siddall & Philip T. Leftwich & Flavia Krsticevic & Philippos Aris Papathanos & Nikolai Windbichler, 2024. "Gene drive and genetic sex conversion in the global agricultural pest Ceratitis capitata," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    5. Tim Harvey-Samuel & Xuechun Feng & Emily M. Okamoto & Deepak-Kumar Purusothaman & Philip T. Leftwich & Luke Alphey & Valentino M. Gantz, 2023. "CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    6. Franck Adama Yao & Abdoul-Azize Millogo & Patric Stephane Epopa & Ace North & Florian Noulin & Koulmaga Dao & Mouhamed Drabo & Charles Guissou & Souleymane Kekele & Moussa Namountougou & Robert Kossiv, 2022. "Mark-release-recapture experiment in Burkina Faso demonstrates reduced fitness and dispersal of genetically-modified sterile malaria mosquitoes," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    7. Jie Du & Weizhe Chen & Xihua Jia & Xuejiao Xu & Emily Yang & Ruizhi Zhou & Yuqi Zhang & Matt Metzloff & Philipp W. Messer & Jackson Champer, 2024. "Germline Cas9 promoters with improved performance for homing gene drive," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    8. Sara Sanz Juste & Emily M. Okamoto & Christina Nguyen & Xuechun Feng & Víctor López Del Amo, 2023. "Next-generation CRISPR gene-drive systems using Cas12a nuclease," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    9. Cisnetto, Valentina & Barlow, James, 2020. "The development of complex and controversial innovations. Genetically modified mosquitoes for malaria eradication," Research Policy, Elsevier, vol. 49(3).
    10. Frieß, Johannes L. & Lalyer, Carina R. & Giese, Bernd & Simon, Samson & Otto, Mathias, 2023. "Review of gene drive modelling and implications for risk assessment of gene drive organisms," Ecological Modelling, Elsevier, vol. 478(C).
    11. Michelle L. Johnson & Bruce A. Hay & Maciej Maselko, 2024. "Altering traits and fates of wild populations with Mendelian DNA sequence modifying Allele Sails," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    12. Beaghton, Andrea & Beaghton, Pantelis John & Burt, Austin, 2016. "Gene drive through a landscape: Reaction–diffusion models of population suppression and elimination by a sex ratio distorter," Theoretical Population Biology, Elsevier, vol. 108(C), pages 51-69.
    13. Weizhe Chen & Jialiang Guo & Yiran Liu & Jackson Champer, 2024. "Population suppression by release of insects carrying a dominant sterile homing gene drive targeting doublesex in Drosophila," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    14. Rocco D’Amato & Chrysanthi Taxiarchi & Marco Galardini & Alessandro Trusso & Roxana L. Minuz & Silvia Grilli & Alastair G. T. Somerville & Dammy Shittu & Ahmad S. Khalil & Roberto Galizi & Andrea Cris, 2024. "Anti-CRISPR Anopheles mosquitoes inhibit gene drive spread under challenging behavioural conditions in large cages," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    15. Han Gao & Yongmao Jiang & Lihua Wang & Guandong Wang & Wenqian Hu & Ling Dong & Sibao Wang, 2023. "Outer membrane vesicles from a mosquito commensal mediate targeted killing of Plasmodium parasites via the phosphatidylcholine scavenging pathway," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    16. Vanessa M. Macias & Johanna R. Ohm & Jason L. Rasgon, 2017. "Gene Drive for Mosquito Control: Where Did It Come from and Where Are We Headed?," IJERPH, MDPI, vol. 14(9), pages 1-30, September.
    17. Daniella An Haber & Yael Arien & Lee Benjamin Lamdan & Yehonathan Alcalay & Chen Zecharia & Flavia Krsticevic & Elad Shmuel Yonah & Rotem Daniel Avraham & Elzbieta Krzywinska & Jaroslaw Krzywinski & E, 2024. "Targeting mosquito X-chromosomes reveals complex transmission dynamics of sex ratio distorting gene drives," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jsusta:v:13:y:2021:i:10:p:5653-:d:557062. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.