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A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

Author

Listed:
  • Nikolai Windbichler

    (Imperial College London, South Kensington Campus)

  • Miriam Menichelli

    (Imperial College London, South Kensington Campus)

  • Philippos Aris Papathanos

    (Imperial College London, South Kensington Campus)

  • Summer B. Thyme

    (University of Washington
    Graduate Program in Biomolecular Structure and Design, University of Washington)

  • Hui Li

    (University of Washington)

  • Umut Y. Ulge

    (University of Washington
    Graduate Program in Molecular and Cellular Biology, University of Washington)

  • Blake T. Hovde

    (University of Washington)

  • David Baker

    (University of Washington
    Graduate Program in Biomolecular Structure and Design, University of Washington
    Howard Hughes Medical Institute, University of Washington)

  • Raymond J. Monnat

    (University of Washington
    Graduate Program in Molecular and Cellular Biology, University of Washington
    University of Washington)

  • Austin Burt

    (Imperial College London, South Kensington Campus
    Imperial College London, Silwood Park Campus)

  • Andrea Crisanti

    (Imperial College London, South Kensington Campus
    University of Perugia, Via Del Giochetto)

Abstract

Manipulating an insect vector Genetic approaches to manipulating or eradicating disease vectors have been proposed as alternatives to malaria eradication. The success of this approach depends on efficient spread of a genetic modification in field populations. Windbichler et al. show that a synthetic genetic element consisting of mosquito regulatory elements and the homing endonuclease gene I-SceI can spread from a small number of individual Anopheles gambiae mosquitoes into large receptive populations in just a few generations. This is the first demonstration of a synthetic gene drive system in the main human malaria vector — and a similar approach should be applicable to many other pest species.

Suggested Citation

  • Nikolai Windbichler & Miriam Menichelli & Philippos Aris Papathanos & Summer B. Thyme & Hui Li & Umut Y. Ulge & Blake T. Hovde & David Baker & Raymond J. Monnat & Austin Burt & Andrea Crisanti, 2011. "A synthetic homing endonuclease-based gene drive system in the human malaria mosquito," Nature, Nature, vol. 473(7346), pages 212-215, May.
    • Handle: RePEc:nat:nature:v:473:y:2011:i:7346:d:10.1038_nature09937
    DOI: 10.1038/nature09937
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    Cited by:

    1. Cisnetto, Valentina & Barlow, James, 2020. "The development of complex and controversial innovations. Genetically modified mosquitoes for malaria eradication," Research Policy, Elsevier, vol. 49(3).
    2. Frieß, Johannes L. & Lalyer, Carina R. & Giese, Bernd & Simon, Samson & Otto, Mathias, 2023. "Review of gene drive modelling and implications for risk assessment of gene drive organisms," Ecological Modelling, Elsevier, vol. 478(C).
    3. Silvia Grilli & Roberto Galizi & Chrysanthi Taxiarchi, 2021. "Genetic Technologies for Sustainable Management of Insect Pests and Disease Vectors," Sustainability, MDPI, vol. 13(10), pages 1-19, May.
    4. Vanessa M. Macias & Johanna R. Ohm & Jason L. Rasgon, 2017. "Gene Drive for Mosquito Control: Where Did It Come from and Where Are We Headed?," IJERPH, MDPI, vol. 14(9), pages 1-30, September.
    5. Sebald A. N. Verkuijl & Estela Gonzalez & Ming Li & Joshua X. D. Ang & Nikolay P. Kandul & Michelle A. E. Anderson & Omar S. Akbari & Michael B. Bonsall & Luke Alphey, 2022. "A CRISPR endonuclease gene drive reveals distinct mechanisms of inheritance bias," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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