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Transforming insect population control with precision guided sterile males with demonstration in flies

Author

Listed:
  • Nikolay P. Kandul

    (University of California, San Diego)

  • Junru Liu

    (University of California, San Diego)

  • Hector M. Sanchez C.

    (University of California)

  • Sean L. Wu

    (University of California)

  • John M. Marshall

    (University of California)

  • Omar S. Akbari

    (University of California, San Diego
    University of California, San Diego)

Abstract

The sterile insect technique (SIT) is an environmentally safe and proven technology to suppress wild populations. To further advance its utility, a novel CRISPR-based technology termed precision guided SIT (pgSIT) is described. PgSIT mechanistically relies on a dominant genetic technology that enables simultaneous sexing and sterilization, facilitating the release of eggs into the environment ensuring only sterile adult males emerge. Importantly, for field applications, the release of eggs will eliminate burdens of manually sexing and sterilizing males, thereby reducing overall effort and increasing scalability. Here, to demonstrate efficacy, we systematically engineer multiple pgSIT systems in Drosophila which consistently give rise to 100% sterile males. Importantly, we demonstrate that pgSIT-generated sterile males are fit and competitive. Using mathematical models, we predict pgSIT will induce substantially greater population suppression than can be achieved by currently-available self-limiting suppression technologies. Taken together, pgSIT offers to potentially transform our ability to control insect agricultural pests and disease vectors.

Suggested Citation

  • Nikolay P. Kandul & Junru Liu & Hector M. Sanchez C. & Sean L. Wu & John M. Marshall & Omar S. Akbari, 2019. "Transforming insect population control with precision guided sterile males with demonstration in flies," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-018-07964-7
    DOI: 10.1038/s41467-018-07964-7
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    Cited by:

    1. Michelle L. Johnson & Bruce A. Hay & Maciej Maselko, 2024. "Altering traits and fates of wild populations with Mendelian DNA sequence modifying Allele Sails," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Tim Harvey-Samuel & Xuechun Feng & Emily M. Okamoto & Deepak-Kumar Purusothaman & Philip T. Leftwich & Luke Alphey & Valentino M. Gantz, 2023. "CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. Sara Sanz Juste & Emily M. Okamoto & Christina Nguyen & Xuechun Feng & Víctor López Del Amo, 2023. "Next-generation CRISPR gene-drive systems using Cas12a nuclease," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    4. Angela Meccariello & Shibo Hou & Serafima Davydova & James Daniel Fawcett & Alexandra Siddall & Philip T. Leftwich & Flavia Krsticevic & Philippos Aris Papathanos & Nikolai Windbichler, 2024. "Gene drive and genetic sex conversion in the global agricultural pest Ceratitis capitata," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    5. Sebald A. N. Verkuijl & Estela Gonzalez & Ming Li & Joshua X. D. Ang & Nikolay P. Kandul & Michelle A. E. Anderson & Omar S. Akbari & Michael B. Bonsall & Luke Alphey, 2022. "A CRISPR endonuclease gene drive reveals distinct mechanisms of inheritance bias," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    6. Silvia Grilli & Roberto Galizi & Chrysanthi Taxiarchi, 2021. "Genetic Technologies for Sustainable Management of Insect Pests and Disease Vectors," Sustainability, MDPI, vol. 13(10), pages 1-19, May.
    7. Stephanie Gamez & Duverney Chaverra-Rodriguez & Anna Buchman & Nikolay P. Kandul & Stelia C. Mendez-Sanchez & Jared B. Bennett & Héctor M. Sánchez C. & Ting Yang & Igor Antoshechkin & Jonny E. Duque &, 2021. "Exploiting a Y chromosome-linked Cas9 for sex selection and gene drive," Nature Communications, Nature, vol. 12(1), pages 1-14, December.

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