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Blood meal-induced inhibition of vector-borne disease by transgenic microbiota

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Listed:
  • Jackie L. Shane

    (Duquesne University)

  • Christina L. Grogan

    (Duquesne University)

  • Caroline Cwalina

    (Duquesne University)

  • David J. Lampe

    (Duquesne University)

Abstract

Vector-borne diseases are a substantial portion of the global disease burden; one of the deadliest of these is malaria. Vector control strategies have been hindered by mosquito and pathogen resistances, and population alteration approaches using transgenic mosquitos still have many hurdles to overcome before they can be implemented in the field. Here we report a paratransgenic control strategy in which the microbiota of Anopheles stephensi was engineered to produce an antiplasmodial effector causing the mosquito to become refractory to Plasmodium berghei. The midgut symbiont Asaia was used to conditionally express the antiplasmodial protein scorpine only when a blood meal was present. These blood meal inducible Asaia strains significantly inhibit pathogen infection, and display improved fitness compared to strains that constitutively express the antiplasmodial effector. This strategy may allow the antiplasmodial bacterial strains to survive and be transmitted through mosquito populations, creating an easily implemented and enduring vector control strategy.

Suggested Citation

  • Jackie L. Shane & Christina L. Grogan & Caroline Cwalina & David J. Lampe, 2018. "Blood meal-induced inhibition of vector-borne disease by transgenic microbiota," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06580-9
    DOI: 10.1038/s41467-018-06580-9
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    Cited by:

    1. Han Gao & Yongmao Jiang & Lihua Wang & Guandong Wang & Wenqian Hu & Ling Dong & Sibao Wang, 2023. "Outer membrane vesicles from a mosquito commensal mediate targeted killing of Plasmodium parasites via the phosphatidylcholine scavenging pathway," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Silvia Grilli & Roberto Galizi & Chrysanthi Taxiarchi, 2021. "Genetic Technologies for Sustainable Management of Insect Pests and Disease Vectors," Sustainability, MDPI, vol. 13(10), pages 1-19, May.

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