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Population suppression by release of insects carrying a dominant sterile homing gene drive targeting doublesex in Drosophila

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  • Weizhe Chen

    (Peking University
    Tsinghua University)

  • Jialiang Guo

    (Peking University
    Peking University)

  • Yiran Liu

    (Peking University)

  • Jackson Champer

    (Peking University)

Abstract

CRISPR homing gene drives can suppress pest populations by targeting female fertility genes, converting wild-type alleles into drive alleles in the germline of drive heterozygotes. fsRIDL (female-specific Release of Insects carrying a Dominant Lethal) is a self-limiting population suppression strategy involving continual release of transgenic males carrying female lethal alleles. Here, we propose an improved pest suppression system called “Release of Insects carrying a Dominant-sterile Drive” (RIDD), combining performance characteristics of homing drive and fsRIDL. We construct a split RIDD system in Drosophila melanogaster by creating a 3-gRNA drive disrupting the doublesex female exon. Drive alleles bias their inheritance in males, while drive alleles and resistance alleles formed by end-joining cause dominant female sterility. Weekly releases of RIDD males progressively suppressed and eventually eliminated cage populations. Modeling shows that RIDD is substantially stronger than SIT and fsRIDL. RIDD is also self-limiting, potentially allowing targeted population suppression.

Suggested Citation

  • Weizhe Chen & Jialiang Guo & Yiran Liu & Jackson Champer, 2024. "Population suppression by release of insects carrying a dominant sterile homing gene drive targeting doublesex in Drosophila," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52473-5
    DOI: 10.1038/s41467-024-52473-5
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    References listed on IDEAS

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    1. Neil M. Ferguson, 2018. "Challenges and opportunities in controlling mosquito-borne infections," Nature, Nature, vol. 559(7715), pages 490-497, July.
    2. Emily Waltz, 2021. "First genetically modified mosquitoes released in the United States," Nature, Nature, vol. 593(7858), pages 175-176, May.
    3. Maciej Maselko & Nathan Feltman & Ambuj Upadhyay & Amanda Hayward & Siba Das & Nathan Myslicki & Aidan J. Peterson & Michael B. O’Connor & Michael J. Smanski, 2020. "Engineering multiple species-like genetic incompatibilities in insects," Nature Communications, Nature, vol. 11(1), pages 1-7, December.
    4. Muyesaier Tudi & Huada Daniel Ruan & Li Wang & Jia Lyu & Ross Sadler & Des Connell & Cordia Chu & Dung Tri Phung, 2021. "Agriculture Development, Pesticide Application and Its Impact on the Environment," IJERPH, MDPI, vol. 18(3), pages 1-23, January.
    5. Ming Li & Ting Yang & Michelle Bui & Stephanie Gamez & Tyler Wise & Nikolay P. Kandul & Junru Liu & Lenissa Alcantara & Haena Lee & Jyotheeswara R. Edula & Robyn Raban & Yinpeng Zhan & Yijin Wang & Ni, 2021. "Suppressing mosquito populations with precision guided sterile males," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    6. Jie Du & Weizhe Chen & Xihua Jia & Xuejiao Xu & Emily Yang & Ruizhi Zhou & Yuqi Zhang & Matt Metzloff & Philipp W. Messer & Jackson Champer, 2024. "Germline Cas9 promoters with improved performance for homing gene drive," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
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    1. Ignacio Tolosana & Katie Willis & Matthew Gribble & Lee Phillimore & Austin Burt & Tony Nolan & Andrea Crisanti & Federica Bernardini, 2025. "A Y chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae," Nature Communications, Nature, vol. 16(1), pages 1-12, December.

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