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Population suppression by release of insects carrying a dominant sterile homing gene drive targeting doublesex in Drosophila

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  • Weizhe Chen

    (Peking University
    Tsinghua University)

  • Jialiang Guo

    (Peking University
    Peking University)

  • Yiran Liu

    (Peking University)

  • Jackson Champer

    (Peking University)

Abstract

CRISPR homing gene drives can suppress pest populations by targeting female fertility genes, converting wild-type alleles into drive alleles in the germline of drive heterozygotes. fsRIDL (female-specific Release of Insects carrying a Dominant Lethal) is a self-limiting population suppression strategy involving continual release of transgenic males carrying female lethal alleles. Here, we propose an improved pest suppression system called “Release of Insects carrying a Dominant-sterile Drive” (RIDD), combining performance characteristics of homing drive and fsRIDL. We construct a split RIDD system in Drosophila melanogaster by creating a 3-gRNA drive disrupting the doublesex female exon. Drive alleles bias their inheritance in males, while drive alleles and resistance alleles formed by end-joining cause dominant female sterility. Weekly releases of RIDD males progressively suppressed and eventually eliminated cage populations. Modeling shows that RIDD is substantially stronger than SIT and fsRIDL. RIDD is also self-limiting, potentially allowing targeted population suppression.

Suggested Citation

  • Weizhe Chen & Jialiang Guo & Yiran Liu & Jackson Champer, 2024. "Population suppression by release of insects carrying a dominant sterile homing gene drive targeting doublesex in Drosophila," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52473-5
    DOI: 10.1038/s41467-024-52473-5
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    References listed on IDEAS

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    1. Ignacio Tolosana & Katie Willis & Matthew Gribble & Lee Phillimore & Austin Burt & Tony Nolan & Andrea Crisanti & Federica Bernardini, 2025. "A Y chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae," Nature Communications, Nature, vol. 16(1), pages 1-12, December.
    2. Xuejiao Xu & Jingheng Chen & You Wang & Yiran Liu & Yongjie Zhang & Jie Yang & Xiaozhen Yang & Bin Chen & Zhengbo He & Jackson Champer, 2025. "Gene drive-based population suppression in the malaria vector Anopheles stephensi," Nature Communications, Nature, vol. 16(1), pages 1-10, December.

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