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Additive subdistribution hazards regression for competing risks data in case‐cohort studies

Author

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  • Adane F. Wogu
  • Haolin Li
  • Shanshan Zhao
  • Hazel B. Nichols
  • Jianwen Cai

Abstract

In survival data analysis, a competing risk is an event whose occurrence precludes or alters the chance of the occurrence of the primary event of interest. In large cohort studies with long‐term follow‐up, there are often competing risks. Further, if the event of interest is rare in such large studies, the case‐cohort study design is widely used to reduce the cost and achieve the same efficiency as a cohort study. The conventional additive hazards modeling for competing risks data in case‐cohort studies involves the cause‐specific hazard function, under which direct assessment of covariate effects on the cumulative incidence function, or the subdistribution, is not possible. In this paper, we consider an additive hazard model for the subdistribution of a competing risk in case‐cohort studies. We propose estimating equations based on inverse probability weighting methods for the estimation of the model parameters. Consistency and asymptotic normality of the proposed estimators are established. The performance of the proposed methods in finite samples is examined through simulation studies and the proposed approach is applied to a case‐cohort dataset from the Sister Study.

Suggested Citation

  • Adane F. Wogu & Haolin Li & Shanshan Zhao & Hazel B. Nichols & Jianwen Cai, 2023. "Additive subdistribution hazards regression for competing risks data in case‐cohort studies," Biometrics, The International Biometric Society, vol. 79(4), pages 3010-3022, December.
    • Handle: RePEc:bla:biomet:v:79:y:2023:i:4:p:3010-3022
    DOI: 10.1111/biom.13821
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    References listed on IDEAS

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    1. Soyoung Kim & Yayun Xu & Mei‐Jie Zhang & Kwang‐Woo Ahn, 2020. "Stratified proportional subdistribution hazards model with covariate‐adjusted censoring weight for case‐cohort studies," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 47(4), pages 1222-1242, December.
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