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Analysis of generalized semiparametric regression models for cumulative incidence functions with missing covariates

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  • Lee, Unkyung
  • Sun, Yanqing
  • Scheike, Thomas H.
  • Gilbert, Peter B.

Abstract

The cumulative incidence function quantifies the probability of failure over time due to a specific cause for competing risks data. The generalized semiparametric regression models for the cumulative incidence functions with missing covariates are investigated. The effects of some covariates are modeled as nonparametric functions of time while others are modeled as parametric functions of time. Different link functions can be selected to add flexibility in modeling the cumulative incidence functions. The estimation procedures based on the direct binomial regression and the inverse probability weighting of complete cases are developed. This approach modifies the full data weighted least squares equations by weighting the contributions of observed members through the inverses of estimated sampling probabilities which depend on the censoring status and the event types among other subject characteristics. The asymptotic properties of the proposed estimators are established. The finite-sample performances of the proposed estimators and their relative efficiencies under different two-phase sampling designs are examined in simulations. The methods are applied to analyze data from the RV144 vaccine efficacy trial to investigate the associations of immune response biomarkers with the cumulative incidence of HIV-1 infection.

Suggested Citation

  • Lee, Unkyung & Sun, Yanqing & Scheike, Thomas H. & Gilbert, Peter B., 2018. "Analysis of generalized semiparametric regression models for cumulative incidence functions with missing covariates," Computational Statistics & Data Analysis, Elsevier, vol. 122(C), pages 59-79.
    • Handle: RePEc:eee:csdana:v:122:y:2018:i:c:p:59-79
    DOI: 10.1016/j.csda.2018.01.003
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    References listed on IDEAS

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    1. Thomas H. Scheike & Mei-Jie Zhang & Thomas A. Gerds, 2008. "Predicting cumulative incidence probability by direct binomial regression," Biometrika, Biometrika Trust, vol. 95(1), pages 205-220.
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    3. Yanqing Sun & Xiyuan Qian & Qiong Shou & Peter B. Gilbert, 2017. "Analysis of two-phase sampling data with semiparametric additive hazards models," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 23(3), pages 377-399, July.
    4. Thomas H. Scheike & Mei-Jie Zhang, 2003. "Extensions and Applications of the Cox-Aalen Survival Model," Biometrics, The International Biometric Society, vol. 59(4), pages 1036-1045, December.
    5. Haneuse, Sebastien & Saegusa, Takumi & Lumley, Thomas, 2011. "osDesign: An R Package for the Analysis, Evaluation, and Design of Two-Phase and Case-Control Studies," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 43(i11).
    6. Yu Shen & S. C. Cheng, 1999. "Confidence Bands for Cumulative Incidence Curves Under the Additive Risk Model," Biometrics, The International Biometric Society, vol. 55(4), pages 1093-1100, December.
    7. John P. Klein & Per Kragh Andersen, 2005. "Regression Modeling of Competing Risks Data Based on Pseudovalues of the Cumulative Incidence Function," Biometrics, The International Biometric Society, vol. 61(1), pages 223-229, March.
    8. Lin D Y & Ying Z, 2001. "Semiparametric and Nonparametric Regression Analysis of Longitudinal Data," Journal of the American Statistical Association, American Statistical Association, vol. 96, pages 103-126, March.
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    Cited by:

    1. Yayun Xu & Soyoung Kim & Mei-Jie Zhang & David Couper & Kwang Woo Ahn, 2022. "Competing risks regression models with covariates-adjusted censoring weight under the generalized case-cohort design," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 28(2), pages 241-262, April.
    2. Adane F. Wogu & Haolin Li & Shanshan Zhao & Hazel B. Nichols & Jianwen Cai, 2023. "Additive subdistribution hazards regression for competing risks data in case‐cohort studies," Biometrics, The International Biometric Society, vol. 79(4), pages 3010-3022, December.

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