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Content
June 2000, Volume 405, Issue 6788
- 857-865 Pharmacogenetics and the practice of medicine
by Allen D. Roses
June 2000, Volume 405, Issue 6787
- 601-601 New Russian science head named
by Carl Levitin - 601-602 Biologists challenge sequencers on parasite genome publication
by Colin Macilwain - 602-603 Drive for more genomes threatens mouse sequence
by Alison Abbott - 603-603 Internet gateway planned for neuroinformatics data
by Paul Smaglik - 603-603 Software spend boosts Israeli R&D
by Haim Watzman - 604-604 Immigrants help offset Canada's brain-drain crisis
by David Spurgeon - 604-604 Spain in quandary over French synchrotron
by Xavier Bosch - 605-605 Roche brings down curtain on Swiss immunology lab
by Alison Abbott - 605-605 A slot in the dock predicted for the chemical industry
by Natasha Loder - 606-607 US decides close tabs must be kept on xenotransplants…
by Declan Butler - 607-607 … and sets up a body to oversee trials
by Paul Smaglik - 610-612 Cloning's owners go to war
by Peter Aldhous - 613-613 Celera's role in opening up new frontiers
by Ken Calvert - 613-613 England and US corner the journal market
by A. A. Waheed - 613-613 Regulation, not private enterprise, is the key to a healthy environment
by George M. Woodwell - 615-615 Climate change in perspective
by Hans von Storch & Nico Stehr - 617-617 Skull and cross words
by Simon Conway Morris - 618-618 The quantum jungle revisited
by Anton Zeilinger - 619-619 Hands-on taxonomy
by Henry Disney - 619-620 The Wonderland of primordial life
by John Godfrey - 620-620 Science in culture
by Alison Abbott - 621-621 Show them how it's really done
by Nancy J. Rothwell - 623-623 New ice age, or just cold feet?
by Norman Spinrad - 625-626 The realms of Archaean life
by Euan Nisbet - 626-627 Semiconductors meet biology
by Chad A. Mirkin & T. Andrew Taton - 627-628 Closing in on γ-secretase
by Bart De Strooper - 629-630 Half-matter, half-light amplifier
by Yoshihisa Yamamoto - 631-631 Gripping feat
by Henry Gee - 631-633 It takes two electrons to tango
by Keith Burnett - 633-634 Pumping ions
by David H. MacLennan & N. Michael Green - 634-634 Pumping a vacuum
by David Jones - 635-635 Recombinant erythropoietin in urine
by Françoise Lasne & Jacques de Ceaurriz - 635-637 Parabasalian flagellates are ancient eukaryotes
by Patrick J. Keeling & Jeffrey D. Palmer - 637-637 Tectonics and water on Europa
by Eric J. Gaidos & Francis Nimmo - 639-646 Scalar turbulence
by Boris I. Shraiman & Eric D. Siggia - 647-655 Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution
by Chikashi Toyoshima & Masayoshi Nakasako & Hiromi Nomura & Haruo Ogawa - 656-658 Newly synthesized lithium in the interstellar medium
by D. C. Knauth & S. R. Federman & David L. Lambert & P. Crane - 658-661 Correlated electron emission in multiphoton double ionization
by Th. Weber & H. Giessen & M. Weckenbrock & G. Urbasch & A. Staudte & L. Spielberger & O. Jagutzki & V. Mergel & M. Vollmer & R. Dörner - 661-665 Improving the performance of doped π-conjugated polymers for use in organic light-emitting diodes
by Markus Gross & David C. Müller & Heinz-Georg Nothofer & Ulrich Scherf & Dieter Neher & Christoph Bräuchle & Klaus Meerholz - 665-668 Selection of peptides with semiconductor binding specificity for directed nanocrystal assembly
by Sandra R. Whaley & D. S. English & Evelyn L. Hu & Paul F. Barbara & Angela M. Belcher - 668-673 Reduced growth of Alaskan white spruce in the twentieth century from temperature-induced drought stress
by Valerie A. Barber & Glenn Patrick Juday & Bruce P. Finney - 673-676 Isotopic evidence for Late Cretaceous plume–ridge interaction at the Hawaiian hotspot
by Randall A. Keller & Martin R. Fisk & William M. White - 676-679 Filamentous microfossils in a 3,235-million-year-old volcanogenic massive sulphide deposit
by Birger Rasmussen - 679-681 Parasite adaptation to locally common host genotypes
by Curtis M. Lively & Mark F. Dybdahl - 681-685 Adhesive force of a single gecko foot-hair
by Kellar Autumn & Yiching A. Liang & S. Tonia Hsieh & Wolfgang Zesch & Wai Pang Chan & Thomas W. Kenny & Ronald Fearing & Robert J. Full - 685-689 Neural synchrony correlates with surface segregation rules
by Miguel Castelo-Branco & Rainer Goebel & Sergio Neuenschwander & Wolf Singer - 689-694 Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1
by Yue-Ming Li & Min Xu & Ming-Tain Lai & Qian Huang & José L. Castro & Jillian DiMuzio-Mower & Timothy Harrison & Colin Lellis & Alan Nadin & Joseph G. Neduvelil & R. Bruce Register & Mohinder K. Sardana & Mark S. Shearman & Adrian L. Smith & Xiao-Ping Shi & Kuo-Chang Yin & Jules A. Shafer & Stephen J. Gardell - 694-697 α-Haemolysin of uropathogenic E. coli induces Ca2+ oscillations in renal epithelial cells
by Per Uhlén & Åsa Laestadius & Timo Jahnukainen & Tomas Söderblom & Fredrik Bäckhed & Gianni Celsi & Hjalmar Brismar & Staffan Normark & Anita Aperia & Agneta Richter-Dahlfors - 697-700 Frequent chromosomal translocations induced by DNA double-strand breaks
by Christine Richardson & Maria Jasin - 701-704 Redundant roles for the TFIID and SAGA complexes in global transcription
by Tong Ihn Lee & Helen C. Causton & Frank C. P. Holstege & Wu-Cheng Shen & Nancy Hannett & Ezra G. Jennings & Fred Winston & Michael R. Green & Richard A. Young - 704-706 Effects of mechanical forces on maintenance and adaptation of form in trabecular bone
by Rik Huiskes & Ronald Ruimerman & G. Harry van Lenthe & Jan D. Janssen - 707-709 Biological sensing of small field differences by magnetically sensitive chemical reactions
by James C. Weaver & Timothy E. Vaughan & R. Dean Astumian - 713-714 US science shocked by revelations of sexual discrimination
by Natasha Loder - 715-716 Making moves to redress the gender imbalance
by Helen Gavaghan - 716-717 New UK legislation aids fight against discrimination
by Helen Gavaghan - 717-717 Canadian aborigines get overlooked
by Potter Wickware - 717-718 US minorities stake their claim in science and engineering
by Potter Wickware - 718-718 Access to education provides a way out
by Potter Wickware
June 2000, Volume 405, Issue 6786
- 495-495 Researchers take US government to court over threat to turtles…
by Natasha Loder - 495-496 …as amphibians come under study
by Rex Dalton - 496-496 Green light for plans to sell off US helium reserve
by Colin Macilwain - 496-496 UK labs impeded by old equipment
by Natasha Loder - 497-497 Clinical trials end at gene-therapy institute…
by Paul Smaglik - 497-497 …as Harvard keeps its ethics guidelines
by Steve Nadis - 498-498 Transmutation of nuclear waste branded ‘Trojan horse’
by Colin Macilwain - 498-498 France plans marine research port at Brest
by Declan Butler - 499-499 Germany edges towards stem-cell accord
by Quirin Schiermeier - 499-499 Survey nets volcanic prize
by Peter Pockley - 500-500 French scientists turn to journals in English
by Declan Butler - 501-501 World's academies seek a sustainable future
by Robert Triendl - 504-506 Requiem for an observatory
by Henry Bortman - 507-507 To conserve rainforest, we have to help local people live sustainably
by S. Jennings & N. D. Brown & T. C. Whitmore & J. N. M. Silva & J. do C. A. Lopes & A. M. V. Baima - 507-508 Impact factors aren't relevant to taxonomy
by Frank-Thorsten Krell - 508-508 Offside researchers score an own goal
by Winfried S. Peters & Bernd Herkner & Alex Webb & Julian Hibberd - 508-508 Giving Arabs credit for Persian works (again)
by Payman Arabshahi - 508-508 We have moral authority to apologize for the past
by Damian Grace & John Carmody - 508-508 Let Armenia show why it's the place for Sesame
by J. S. Hovnanian - 509-509 Time for voices to be raised
by Derek Burke - 511-512 The house that Jim built
by Sydney Brenner - 512-513 Mozart, McCartney and sexual selection
by Margaret A. Boden - 513-513 Statistical detective
by Ian Hacking - 514-514 Making sense of a small world
by Maxine Clarke - 515-515 A double-edged sword
by Diane Paul - 517-517 Catching crumbs from the table
by Ted Chiang - 519-520 Pax Argentinica
by David C. Queller - 520-521 Neutralizing noise in gene networks
by Timothy S. Gardner & James J. Collins - 521-523 Hard knock for thermodynamics
by Salvatore Torquato - 523-525 Learning how the brain learns
by Eilon Vaadia - 525-525 Case of the bends
by Tim Lincoln - 525-526 A watched pot boils quicker
by Peter W. Milonni - 527-528 The footprint of a killer
by Klas Kärre & Gunter Schneider - 528-528 Air currents
by David Jones - 529-530 Pacific leatherback turtles face extinction
by James R. Spotila & Richard D. Reina & Anthony C. Steyermark & Pamela T. Plotkin & Frank V. Paladino - 530-531 Fossil record of mass moth migration
by Jes Rust - 531-532 Presenilin-1 mutations in Alzheimer's disease
by C. Russo & G. Schettini & T. C. Saido & C. Hulette & C. Lippa & L. Lannfelt & B. Ghetti & P. Gambetti & M. Tabaton & J. K. Teller - 532-532 A massive cool dust torus around η Carinae?
by Kris Davidson & Nathan Smith - 533-536 Inferring the statistical interpretation of quantum mechanics from the classical limit
by Kurt Gottfried - 537-543 Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand
by Jeffrey C. Boyington & Shawn A. Motyka & Peter Schuck & Andrew G. Brooks & Peter D. Sun - 544-546 Rossby waves on the Sun as revealed by solar ‘hills’
by J. R. Kuhn & J. D. Armstrong & R. I. Bush & P. Scherrer - 546-550 Acceleration of quantum decay processes by frequent observations
by A. G. Kofman & G. Kurizki - 550-551 Absence of thermodynamic phase transition in a model glass former
by Ludger Santen & Werner Krauth - 552-554 Dynamics of the silicon (111) surface phase transition
by J. B. Hannon & H. Hibino & N. C. Bartelt & B. S. Swartzentruber & T. Ogino & G. L. Kellogg - 555-559 Old radiocarbon ages in the southwest Pacific Ocean during the last glacial period and deglaciation
by Elisabeth L. Sikes & Catherine R. Samson & Thomas P. Guilderson & William R. Howard - 559-562 Multiple seismic discontinuities near the base of the transition zone in the Earth's mantle
by N. A. Simmons & H. Gurrola - 562-565 Are lemmings prey or predators?
by P. Turchin & L. Oksanen & P. Ekerholm & T. Oksanen & H. Henttonen - 565-567 Highly fecund mothers sacrifice offspring survival to maximize fitness
by Sigurd Einum & Ian A. Fleming - 567-571 Cortical ensemble activity increasingly predicts behaviour outcomes during learning of a motor task
by Mark Laubach & Johan Wessberg & Miguel A. L. Nicolelis - 571-575 An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channel
by Inyeong Choi & Christian Aalkjaer & Emile L. Boulpaep & Walter F. Boron - 575-579 Cyclin D control of growth rate in plants
by Claire E. Cockcroft & Bart G. W. den Boer & J. M. Sandra Healy & James A. H. Murray - 579-583 Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway
by Glenn C. Turner & Fangyong Du & Alexander Varshavsky - 583-586 Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule
by Craig H. Bassing & Frederick W. Alt & Maureen M. Hughes & Margaux D'Auteuil & Tara D. Wehrly & Barbara B. Woodman & Frank Gärtner & J. Michael White & Laurie Davidson & Barry P. Sleckman - 586-590 Intraprotein radical transfer during photoactivation of DNA photolyase
by Corinne Aubert & Marten H. Vos & Paul Mathis & André P. M. Eker & Klaus Brettel - 590-593 Engineering stability in gene networks by autoregulation
by Attila Becskei & Luis Serrano - 597-597 Germany faces up to its labour shortage
by Diane Gershon - 597-598 US Congress encouraged to lay out the welcome mat for skilled foreigners
by Diane Gershon - 598-598 The economic impact of Silicon Valley's immigrant entrepreneurs
by Diane Gershon
May 2000, Volume 405, Issue 6785
- 381-381 France sets up élite Internet school
by Heather McCabe - 381-382 US astronomers draw up their wish list for a decade of funding
by Tony Reichhardt - 382-383 Britain asks to join European Southern Observatory
by David Dickson & Alison Abbott - 383-383 Mathematicians chase the seven million-dollar proofs
by David Dickson - 384-384 BioMed Central boosted by editorial board
by Declan Butler - 384-384 Russian PM supports science
by Carl Levitin - 385-385 French unions upset by plans for physiology centre
by Heather McCabe - 385-385 Congress wakes up to climate change
by Colin Macilwain - 386-386 Bacterial AIDS vaccine ready for testing
by Paul Smaglik - 387-387 Tax blow leaves Australian science reeling
by Peter Pockley - 389-389 Changing of the guard
by Trisha Gura - 390-392 Deep thoughts
by Rex Dalton - 393-393 It's time to work together and stop duplicating conservation efforts …
by G. M. Mace & A. Balmford & L. Boitani & G. Cowlishaw & A. P. Dobson & D. P. Faith & K. J. Gaston & C. J. Humphries & R. I. Vane-Wright & P. H. Williams & J. H. Lawton & C. R. Margules & R. M. May & A. O. Nicholls & H. P. Possingham & C. Rahbek & A. S. van Jaarsveld - 393-394 … following Africa's lead in setting priorities
by Gustavo A. B. da Fonseca & Andrew Balmford & Colin Bibby & Luigi Boitani & Fabio Corsi & Thomas Brooks & Claude Gascon & Silvio Olivieri & Russell A. Mittermeier & Neil Burgess & Eric Dinerstein & David Olson & Lee Hannah & Jon Lovett & David Moyer & Carsten Rahbek & Simon Stuart & Paul Williams - 394-394 Community groups could show Unesco the way
by Gérard Toulouse - 395-396 It won't come to the Crunch
by William H. Press - 396-396 Stopping the tectonic conveyor belt
by David Bercovici - 397-397 A Gouldian valediction, almost
by Henry Gee - 397-398 The many faces of science
by Lisa Jardine - 399-399 Many paths to enlightenment
by Susantha Goonatilake - 401-401 Brochure
by Joe Haldeman - 403-404 Loophole for snowball Earth
by Bruce Runnegar - 404-405 New link in a web of human genes
by Jean Y. J. Wang - 405-407 Three's a crowd
by Alan P. Boss - 408-409 Silence across the border
by Wolf Reik & Adele Murrell - 411-412 Inner core takes another turn
by Henri-Claude Nataf - 412-412 Carbon fixation
by Jim Gillon - 412-413 The power of design
by Mark Newman - 413-414 Self-regulating synapses
by Christine R. Rose & Arthur Konnerth - 414-414 Opal appeal
by Karen Southwell - 415-415 The bases for Cockayne syndrome
by Philip C. Hanawalt - 416-416 The depths of madness
by David Jones - 417-417 Wireless capsule endoscopy
by Gavriel Iddan & Gavriel Meron & Arkady Glukhovsky & Paul Swain - 417-418 Non-thermal heat-shock response to microwaves
by David de Pomerai & Clare Daniells & Helen David & Joanna Allan & Ian Duce & Mohammed Mutwakil & David Thomas & Phillip Sewell & John Tattersall & Don Jones & Peter Candido - 418-419 Proton-powered turbine of a plant motor
by Holger Seelert & Ansgar Poetsch & Norbert A. Dencher & Andreas Engel & Henning Stahlberg & Daniel J. Müller - 421-424 Roles of PPARs in health and disease
by Sander Kersten & Béatrice Desvergne & Walter Wahli - 425-429 Neoproterozoic ‘snowball Earth’ simulations with a coupled climate/ice-sheet model
by William T. Hyde & Thomas J. Crowley & Steven K. Baum & W. Richard Peltier - 430-433 A triplet of differently shaped spin-zero states in the atomic nucleus 186Pb
by A. N. Andreyev & M. Huyse & P. Van Duppen & L. Weissman & D. Ackermann & J. Gerl & F. P. Hessberger & S. Hofmann & A. Kleinböhl & G. Münzenberg & S. Reshitko & C. Schlegel & H. Schaffner & P. Cagarda & M. Matos & S. Saro & A. Keenan & C. Moore & C. D. O'Leary & R. D. Page & M. Taylor & H. Kettunen & M. Leino & A. Lavrentiev & R. Wyss & K. Heyde - 433-437 Microdomain patterns from directional eutectic solidification and epitaxy
by Claudio De Rosa & Cheolmin Park & Edwin L. Thomas & Bernard Lotz - 437-440 Large-scale synthesis of a silicon photonic crystal with a complete three-dimensional bandgap near 1.5 micrometres
by Alvaro Blanco & Emmanuel Chomski & Serguei Grabtchak & Marta Ibisate & Sajeev John & Stephen W. Leonard & Cefe Lopez & Francisco Meseguer & Hernan Miguez & Jessica P. Mondia & Geoffrey A. Ozin & Ovidiu Toader & Henry M. van Driel - 440-442 Deep convective clouds with sustained supercooled liquid water down to -37.5 °C
by Daniel Rosenfeld & William L. Woodley - 442-445 Past temperature and δ18O of surface ocean waters inferred from foraminiferal Mg/Ca ratios
by H. Elderfield & G. Ganssen - 445-448 Slow differential rotation of the Earth's inner core indicated by temporal changes in scattering
by John E. Vidale & Doug A. Dodge & Paul S. Earle - 448-450 Invasion sequence affects predator–prey dynamics in a multi-species interaction
by Steven M. Sait & Wei-Chung Liu & David J. Thompson & H. Charles J. Godfray & Michael Begon - 451-454 Chromosomal evolution in Saccharomyces
by G. Fischer & S. A. James & I. N. Roberts & S. G. Oliver & E. J. Louis - 454-458 Synaptic activity at calcium-permeable AMPA receptors induces a switch in receptor subtype
by Si-Qiong June Liu & Stuart G. Cull-Candy - 458-462 Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
by Lyudmila V. Borovikova & Svetlana Ivanova & Minghuang Zhang & Huan Yang & Galina I. Botchkina & Linda R. Watkins & Haichao Wang & Naji Abumrad & John W. Eaton & Kevin J. Tracey - 462-466 Targeted destabilization of HY5 during light-regulated development of Arabidopsis
by Mark T. Osterlund & Christian S. Hardtke & Ning Wei & Xing Wang Deng - 473-477 Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
by Song Zhao & Yi-Chinn Weng & Shyng-Shiou F. Yuan & Yi-Tzu Lin & Hao-Chi Hsu & Suh-Chin J. Lin & Elvira Gerbino & Mei-hua Song & Malgorzata Z. Zdzienicka & Richard A. Gatti & Jerry W. Shay & Yael Ziv & Yosef Shiloh & Eva Y.-H. P. Lee - 477-482 ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
by Xiaohua Wu & Velvizhi Ranganathan & David S. Weisman & Walter F. Heine & David N. Ciccone & Ted B. O'Neill & Kindra E. Crick & Kerry A. Pierce & William S. Lane & Gary Rathbun & David M. Livingston & David T. Weaver - 482-485 Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
by Adam C. Bell & Gary Felsenfeld - 486-489 CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
by Amy T. Hark & Christopher J. Schoenherr & David J. Katz & Robert S. Ingram & John M. Levorse & Shirley M. Tilghman
May 2000, Volume 405, Issue 6784
- 261-262 Europe agrees to boost Internet networks used by researchers
by Declan Butler - 262-262 Congo war increases threat to bonobo research
by Asako Saegusa - 262-262 NIH takes charge of chimps infected in experiments
by Paul Smaglik - 263-263 …but South Africa voices reservations
by Michael Cherry - 263-263 Cheaper AIDS drugs due for Third World…
by Phyllida Brown - 264-264 Geneticist from Baylor named as new head of UK's Sanger Centre
by David Dickson - 264-264 Los Alamos labs are safe from fire
by Rex Dalton - 264-264 Researchers take a gamble on the human genome
by Paul Smaglik - 265-265 Gene bank to offer family album of mammals
by Natasha Loder - 265-265 Japan calls for open access to human genome data
by Robert Triendl - 266-267 Greens persuade Europe to revoke patent on neem tree…
by Ulrike Hellerer & K. S. Jarayaman - 267-267 …as India pushes ahead with plant database
by K. S. Jarayaman - 270-272 Reservoirs dog AIDS therapy
by Paul Smaglik - 273-273 AIDS dissidents aren't victims — but the people their ideas kill will be
by Edward Rybicki & Anna-Lise Williamson & Lynn Morris - 273-273 Bureaucracy strangles Latin American research
by Julio E. Pérez & Abul K. Bashirullah - 275-276 Emblem of a golden era
by W. F. Bynum - 276-277 Witness after the event
by Mark Benecke - 277-278 Of viruses and men
by Robin A. Weiss - 278-278 Science in culture
by Martin Kemp - 279-279 More is less
by Terence Kealey - 281-281 Consequences
by Poul Anderson - 283-284 Recounting a genetic story
by Roger H. Reeves - 285-287 The comet no one saw
by Michael F. A'Hearn - 287-288 Checkpoint for invasion
by Lance A. Liotta & Timothy Clair - 288-291 Nutrients in the glacial balance
by Peggy Delaney - 291-292 Bioluminescence illuminated
by Franklyn G. Prendergast - 292-292 Centrioles go for a stroll
by Manfred Schliwa - 293-294 Plastic sandwiches à la carte
by Michael D. Ward - 294-294 Drink without drinking
by David Jones