IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v406y2000i6793d10.1038_35018581.html
   My bibliography  Save this article

A chemokine-driven positive feedback loop organizes lymphoid follicles

Author

Listed:
  • K. Mark Ansel

    (Department of Microbiology and Immunology University of California San Francisco)

  • Vu N. Ngo

    (Department of Microbiology and Immunology University of California San Francisco)

  • Paul L. Hyman

    (Department of Microbiology and Immunology University of California San Francisco)

  • Sanjiv A. Luther

    (Department of Microbiology and Immunology University of California San Francisco)

  • Reinhold Förster

    (Molecular Tumorgenetics and Immunogenetics, Max-Delbrück-Center for Molecular Medicine)

  • Jonathon D. Sedgwick

    (DNAX Research Institute)

  • Jeffrey L. Browning

    (Biogen Inc.)

  • Martin Lipp

    (Molecular Tumorgenetics and Immunogenetics, Max-Delbrück-Center for Molecular Medicine)

  • Jason G. Cyster

    (Department of Microbiology and Immunology University of California San Francisco)

Abstract

Lymphoid follicles are B-cell-rich compartments of lymphoid organs that function as sites of B-cell antigen encounter and differentiation. CXC chemokine receptor-5 (CXCR5) is required for B-cell migration to splenic follicles1, but the requirements for homing to B-cell areas in lymph nodes remain to be defined. Here we show that lymph nodes contain two types of B-cell-rich compartment: follicles containing follicular dendritic cells, and areas lacking such cells. Using gene-targeted mice, we establish that B-lymphocyte chemoattractant (BLC/BCA1)2,3 and its receptor, CXCR5, are needed for B-cell homing to follicles in lymph nodes as well as in spleen. We also find that BLC is required for the development of most lymph nodes and Peyer's patches. In addition to mediating chemoattraction, BLC induces B cells to upregulate membrane lymphotoxin α1β2, a cytokine that promotes follicular dendritic cell development and BLC expression4,5, establishing a positive feedback loop that is likely to be important in follicle development and homeostasis. In germinal centres the feedback loop is overridden, with B-cell lymphotoxin α1β2 expression being induced by a mechanism independent of BLC.

Suggested Citation

  • K. Mark Ansel & Vu N. Ngo & Paul L. Hyman & Sanjiv A. Luther & Reinhold Förster & Jonathon D. Sedgwick & Jeffrey L. Browning & Martin Lipp & Jason G. Cyster, 2000. "A chemokine-driven positive feedback loop organizes lymphoid follicles," Nature, Nature, vol. 406(6793), pages 309-314, July.
    • Handle: RePEc:nat:nature:v:406:y:2000:i:6793:d:10.1038_35018581
    DOI: 10.1038/35018581
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35018581
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/35018581?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Nannan Guo & Na Li & Li Jia & Qinyue Jiang & Mette Schreurs & Vincent Unen & Susana M. Chuva Sousa Lopes & Alexandra A. Vloemans & Jeroen Eggermont & Boudewijn Lelieveldt & Frank J. T. Staal & Noel F., 2023. "Immune subset-committed proliferating cells populate the human foetal intestine throughout the second trimester of gestation," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:406:y:2000:i:6793:d:10.1038_35018581. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.