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Content
November 2000, Volume 408, Issue 6809
- 233-238 Why do we age?
by Thomas B. L. Kirkwood & Steven N. Austad - 239-247 Oxidants, oxidative stress and the biology of ageing
by Toren Finkel & Nikki J. Holbrook - 248-254 The age of cancer
by Ronald A. DePinho - 255-262 Genetic pathways that regulate ageing in model organisms
by Leonard Guarente & Cynthia Kenyon - 263-266 Lessons from human progeroid syndromes
by George M. Martin & Junko Oshima - 267-269 The future of ageing
by Leonard Hayflick - 273-274 Structural genomics — from cottage industry to industrial revolution
by Diane Gershon
November 2000, Volume 408, Issue 6808
- 3-4 Inquiry blames missed warnings for scale of Britain's BSE crisis
by Peter Aldhous - 4-4 Were some CJD victims infected by vaccines?
by Karen Birmingham - 5-5 Scientific turf war 'delayed potentially vital research'
by David Dickson - 6-6 Kenyans protest at being left off AIDS patent
by Wachira Kigotho - 6-7 Puffer fish joins genome stampede
by David Cyranoski & Paul Smaglik - 7-7 US fusion community 'must end isolation', says panel
by Colin Macilwain - 7-7 Whitehead enters into array deal
by Steve Nadis - 8-8 Aquarium group fights 'cyanide fishing' . .
by Mark Schrope - 9-9 . . . as scientists raise alarm over coral reefs
by Peter Pockley - 13-15 Does size matter?
by Alexander Hellemans - 017-017 Genes should not be patentable, but if they are, we all have to do it
by Edgar Dutra Zanotto - 17-17 Results may not fit well with current theories . .
by Gabby Dover - 17-18 . . . but yeast prion offers clues about evolution
by Susan Lindquist - 18-18 In defence of Spanish R&D spending
by Ramón Marimon - 18-18 Don't ignore the risk of vaccine contamination
by G. Lecatsas - 19-20 Is Russian science recovering?
by Irina Dezhina & Loren Graham - 21-22 A powerful leap from chaos
by Niall Ferguson - 22-23 From pioneers to marketeers
by Rino Rappuoli - 23-24 Secrets will out
by Simon Singh - 24-25 Now you see it, now you don't
by Douglas R. O. Morrison - 27-28 With a hammer and passion
by Philippe Janvier - 30-31 Metamorphosis of a brain
by Yadin Dudai - 31-32 Unravelling a tangled mind
by Bruce A. Yankner - 33-33 What's in a name?
by Sandra Knapp - 35-35 The stars my incarnation
by Robert A. Metzger - 37-38 Small but mighty timekeepers
by André Adoutte - 38-39 Surprising movements in solids
by Ulrich Gösele - 39-41 Turning fields into grains
by Richard D. Thompson - 42-43 An auroral signature decoded
by Patrick T. Newell - 43-45 One cell, two fates
by Peter Carmeliet - 45-46 Flipping a molecular switch
by Dan Feldheim - 46-47 Regulation of the regulators
by Scott Stewart & Gerald R. Crabtree - 47-48 Cosmic discord
by Craig J. Hogan - 49-50 Global spread of microorganisms by ships
by Gregory M. Ruiz & Tonya K. Rawlings & Fred C. Dobbs & Lisa A. Drake & Timothy Mullady & Anwarul Huq & Rita R. Colwell - 50-50 The smallest carbon nanotube
by Lu-Chang Qin & Xinluo Zhao & Kaori Hirahara & Yoshiyuki Miyamoto & Yoshinori Ando & Sumio Iijima - 50-51 Single-walled 4 Å carbon nanotube arrays
by N. Wang & Z. K. Tang & G. D. Li & J. S. Chen - 51-52 Hydrodynamic stimuli and the fish lateral line
by J. Engelmann & W. Hanke & J. Mogdans & H. Bleckmann - 53-56 Telomere states and cell fates
by Elizabeth H. Blackburn - 57-63 Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function
by Julia Parrish-Novak & Stacey R. Dillon & Andrew Nelson & Angie Hammond & Cindy Sprecher & Jane A. Gross & Janet Johnston & Karen Madden & Wenfeng Xu & Jim West & Sara Schrader & Steve Burkhead & Mark Heipel & Cameron Brandt & Joseph L. Kuijper & Janet Kramer & Darrell Conklin & Scott R. Presnell & Jon Berry & Faith Shiota & Susan Bort & Kevin Hambly & Sherri Mudri & Chris Clegg & Margaret Moore & Francis J. Grant & Catherine Lofton-Day & Teresa Gilbert & Fenella Raymond & Andrew Ching & Lena Yao & Deb Smith & Philippa Webster & Theodore Whitmore & Mark Maurer & Kenneth Kaushansky & Rick D. Holly & Don Foster - 64-67 A photorefractive organically modified silica glass with high optical gain
by Pavel Cheben & Francisco del Monte & Dennis J. Worsfold & Dave J. Carlsson & Chander P. Grover & John D. Mackenzie - 67-69 A nanometre-scale electronic switch consisting of a metal cluster and redox-addressable groups
by David I. Gittins & Donald Bethell & David J. Schiffrin & Richard J. Nichols - 69-72 Large disparity between gallium and antimony self-diffusion in gallium antimonide
by H. Bracht & S. P. Nicols & W. Walukiewicz & J. P. Silveira & F. Briones & E. E. Haller - 72-75 Early onset and tropical forcing of 100,000-year Pleistocene glacial cycles
by Scott Rutherford & Steven D'Hondt - 75-78 Accelerated hydration of the Earth's deep crust induced by stress perturbations
by Bjørn Jamtveit & Håkon Austrheim & Anders Malthe-Sørenssen - 79-82 Elevated CO2 increases productivity and invasive species success in an arid ecosystem
by Stanley D. Smith & Travis E. Huxman & Stephen F. Zitzer & Therese N. Charlet & David C. Housman & James S. Coleman & Lynn K. Fenstermaker & Jeffrey R. Seemann & Robert S. Nowak - 82-86 Evolutionary origins of vertebrate appendicular muscle
by C. Neyt & K. Jagla & C. Thisse & B. Thisse & L. Haines & P. D. Currie - 86-89 Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
by Amy E. Pasquinelli & Brenda J. Reinhart & Frank Slack & Mark Q. Martindale & Mitzi I. Kuroda & Betsy Maller & David C. Hayward & Eldon E. Ball & Bernard Degnan & Peter Müller & Jürg Spring & Ashok Srinivasan & Mark Fishman & John Finnerty & Joseph Corbo & Michael Levine & Patrick Leahy & Eric Davidson & Gary Ruvkun - 89-92 Polarization of the anterior–posterior axis of C. elegans is a microtubule-directed process
by Matthew R. Wallenfang & Geraldine Seydoux - 92-96 Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors
by Jun Yamashita & Hiroshi Itoh & Masanori Hirashima & Minetaro Ogawa & Satomi Nishikawa & Takami Yurugi & Makoto Naito & Kazuwa Nakao & Shin-Ichi Nishikawa - 96-101 Bidirectional control of airway responsiveness by endogenous cannabinoids
by A. Calignano & I. Kátona & F. Désarnaud & A. Giuffrida & G. La Rana & K. Mackie & T. F. Freund & D. Piomelli - 101-106 Identification of genes that modify ataxin-1-induced neurodegeneration
by Pedro Fernandez-Funez & Maria Laura Nino-Rosales & Beatrice de Gouyon & Wei-Chi She & James M. Luchak & Pedro Martinez & Enrique Turiegano & Jonathan Benito & Maria Capovilla & Pamela J. Skinner & Alanna McCall & Inmaculada Canal & Harry T. Orr & Huda Y. Zoghbi & Juan Botas - 106-111 Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation
by Timothy A. McKinsey & Chun-Li Zhang & Jianrong Lu & Eric N. Olson - 111-115 Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
by Yingwu Xu & Xiao Tao & Baohe Shen & Tiffany Horng & Ruslan Medzhitov & James L. Manley & Liang Tong - 115-120 Structural basis for the activation of 20S proteasomes by 11S regulators
by Frank G. Whitby & Eugene I. Masters & Larissa Kramer & J. Randolph Knowlton & Yi Yao & Ching C. Wang & Christopher P. Hill - 120-120 Erratum: Production of gene-targeted sheep by nuclear transfer from cultured somatic cells
by K. J. McCreath & J. Howcroft & K. H. S. Campbell & A. Colman & A. E. Schnieke & A. J. Kind
October 2000, Volume 407, Issue 6807
- 931-931 Four more moons for Saturn
by David Adam - 931-931 NSF calls for funding boost in a bid to reverse decline in maths
by Paul Smaglik - 932-932 UK ministry under fire over handling of BSE research
by David Dickson - 932-932 Global warming identified as main threat to coral reefs
by Peter Pockley - 932-932 Carbon sequestration gains support
by Colin Macilwain - 933-933 Fan mail demands reprieve for delayed US Pluto mission
by William Triplett - 933-933 US Geological Survey needs more resources, says draft report
by Rex Dalton - 934-934 Human Frontier repatriation boost
by Quirin Schiermeier - 934-934 Germany gives green light to gene patents
by Quirin Schiermeier - 935-935 Singapore to create nationwide disease database
by David Cyranoski - 935-935 Japanese court backs woman researcher
by Robert Triendl - 938-940 Clean and green. . .but are they mean?
by David Adam - 941-941 No evidence to link polio vaccine with HIV ..
by Stanley A. Plotkin & Hilary Koprowski - 941-941 Returners not welcome at Spanish universities
by Pau Ferrer - 941-941 Disease should be targeted from all angles
by M. F. Greaves - 943-943 Sexually transmitted retribution
by W. F. Bynum - 944-945 Ways to get them through the door
by Graham Farmelo - 945-945 Life and times of a pioneering polymath
by Thomas R. Dunlap - 945-946 Parasites at the heart of ecology
by Ted J. Case - 946-946 Science in culture
by Philip Ball - 947-947 High achiever
by Mott T. Greene - 949-949 A Leap of Faith
by Prof. Theo Von Hohenheim - 951-952 ATP, pain and a full bladder
by Sean P. Cook & Edwin W. McCleskey - 953-953 Convoluted communications
by Amanda Tromans - 953-955 The red ragged edge
by Brian G. Marsden - 955-956 Why are some males dull?
by Tore Slagsvold - 956-959 Clues from corals
by Robert B. Dunbar - 959-959 Crossroads in carbon
by Liesbeth Venema - 959-960 Carbon fix for a diatom
by Ulf Riebesell - 961-962 Insecticides and mosquito-borne disease
by L. McCarroll & M. G. Paton & S. H. P. P. Karunaratne & H. T. R. Jayasuryia & K. S. P. Kalpage & J. Hemingway - 962-962 Paying for sex is not easy
by S. A. West & A. D. Peters - 963-970 Regenerating the damaged central nervous system
by Philip J. Horner & Fred H. Gage - 971-977 Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor
by Naoki Kunishima & Yoshimi Shimada & Yuji Tsuji & Toshihiro Sato & Masaki Yamamoto & Takashi Kumasaka & Shigetada Nakanishi & Hisato Jingami & Kosuke Morikawa - 979-981 Extremely red Kuiper-belt objects in near-circular orbits beyond 40 AU
by S. C. Tegler & W. Romanishin - 981-983 n-type colloidal semiconductor nanocrystals
by Moonsub Shim & Philippe Guyot-Sionnest - 983-986 Three-dimensional control of light in a two-dimensional photonic crystal slab
by Edmond Chow & S.Y. Lin & S.G. Johnson & P.R. Villeneuve & J.D. Joannopoulos & J.R. Wendt & G.A. Vawter & W. Zubrzycki & H. Hou & A. Alleman - 986-989 Geometry-dominated fluid adsorption on sculpted solid substrates
by C. Rascón & A. O. Parry - 989-993 Influence of mean climate change on climate variability from a 155-year tropical Pacific coral record
by Frank E. Urban & Julia E. Cole & Jonathan T. Overpeck - 993-996 Widespread uplift and ‘trapdoor’ faulting on Galápagos volcanoes observed with radar interferometry
by Falk Amelung & Sigurjón Jónsson & Howard Zebker & Paul Segall - 996-999 Unicellular C4 photosynthesis in a marine diatom
by John R. Reinfelder & Anne M. L. Kraepiel & François M. M. Morel - 1000-1003 Disruptive sexual selection for plumage coloration in a passerine bird
by Erick Greene & Bruce E. Lyon & Vincent R. Muehter & Laurene Ratcliffe & Steven J. Oliver & Peter T. Boag - 1003-1007 An area for vergence eye movement in primate frontal cortex
by Paul D. Gamlin & Kyunghee Yoon - 1007-1011 The mammalian sodium channel BNC1 is required for normal touch sensation
by Margaret P. Price & Gary R. Lewin & Sabrina L. McIlwrath & Chun Cheng & Jinghui Xie & Paul A. Heppenstall & Cheryl L. Stucky & Anne G. Mannsfeldt & Timothy J. Brennan & Heather A. Drummond & Jing Qiao & Christopher J. Benson & Deirdre E. Tarr & Ron F. Hrstka & Baoli Yang & Roger A. Williamson & Michael J. Welsh - 1011-1015 Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice
by Debra A. Cockayne & Sara G. Hamilton & Quan-Ming Zhu & Philip M. Dunn & Yu Zhong & Sanja Novakovic & Annika B. Malmberg & Gary Cain & Amy Berson & Laura Kassotakis & Linda Hedley & Wilhelm G. Lachnit & Geoffrey Burnstock & Stephen B. McMahon & Anthony P. D. W. Ford - 1015-1017 Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors
by Veronika Souslova & Paolo Cesare & Yanning Ding & Armen N. Akopian & Louise Stanfa & Rie Suzuki & Katherine Carpenter & Anthony Dickenson & Susan Boyce & Ray Hill & Daniela Nebenius-Oosthuizen & Andrew J.H. Smith & Emma J. Kidd & John N. Wood - 1018-1022 Frequent ectopic recombination of virulence factor genes in telomeric chromosome clusters of P. falciparum
by Lúcio H. Freitas-Junior & Emmanuel Bottius & Lindsay A. Pirrit & Kirk W. Deitsch & Christine Scheidig & Francoise Guinet & Ulf Nehrbass & Thomas E. Wellems & Artur Scherf - 1022-1026 Matrix proteins can generate the higher order architecture of the Golgi apparatus
by Joachim Seemann & Eija Jokitalo & Marc Pypaert & Graham Warren - 1026-1029 Steps and fluctuations of Listeria monocytogenes during actin-based motility
by Scot C. Kuo & James L. McGrath - 1029-1034 Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin
by Luca Pellegrini & David F. Burke & Frank von Delft & Barbara Mulloy & Tom L. Blundell
October 2000, Volume 407, Issue 6806
- 821-821 Spain's science figures under fire
by Xavier Bosch - 821-821 Tissue donors use their influence in deal over gene patent terms
by Paul Smaglik - 822-822 UK to make the northwest a post-genomics hotspot
by David Adam - 822-822 Mbeki agrees to step back from AIDS debate
by Michael Cherry - 823-823 NSF puts big money into complex ecology
by Colin Macilwain - 823-824 Deep roots of Nazi science revealed
by Alison Abbott & Quirin Schiermeier - 824-824 Canada plans reduction in greenhouse-gas emissions
by David Spurgeon - 824-824 US court slashes damages in polymerase-β theft case
by Rex Dalton - 825-825 Anger as Princeton closes 'inspirational' museum
by Rex Dalton - 825-825 French take physics archives into the future
by Declan Butler - 828-829 For my next trick. .
by Paul Smaglik - 830-831 India's finest, for hire
by K. S. Jayaraman - 833-833 Enigma thief stole a very special machine
by E. T. Hall - 833-833 Careers in science offer women an unusual bonus: immortality
by Dean Falk - 833-834 Did civil reactors supply plutonium for weapons?
by K. W. J. Barnham & J. Nelson & R. A. Stevens - 834-834 If free speech costs lives that's a high price to pay
by Simon Wain-Hobson & Robin A. Weiss - 834-834 . . .yet the path is strewn with needless obstacles
by Ricardo de Souza Pereira - 834-834 Achievers should stay to aid Brazilian science . .
by Maria J. Hötzel - 835-836 A many-feathered tale
by Susan E. Lederer - 836-836 Cultivating the power of the empire
by Lewis Pyenson - 836-837 A warm topic for cogitation
by Andrew R. Cossins - 837-838 Catch as catch can?
by John Godfrey - 838-838 Science in culture
by Martin Kemp - 839-839 Prophets without honour?
by R. M. Simmons - 841-841 Subpoenaed in Syracuse
by Tom Holt - 843-844 Identifying cosmic muck
by Harry Y. McSween - 844-845 A case of bacterial immortality?
by R. John Parkes - 845-847 Tuning channels for blood pressure
by Nick Standen - 848-849 Tracing the Earth's evolution
by Mark Rehkämper - 849-851 Mitrates on the move
by Henry Gee - 851-852 A world in transition…
by Harry Elderfield - 852-853 One man's food
by Mitchell A. Lazar - 854-854 Robert H. Abeles (1926–2000)
by Lizbeth Hedstrom & Perry A. Frey - 855-856 Genital damage, kicking and early death
by Helen S. Crudgington & Mike T. Siva-Jothy - 856-857 Is acidification still an ecological threat?
by C. Alewell & B. Manderscheid & H. Meesenburg & J. Bittersohl - 857-858 reply: Is acidification still an ecological threat?
by J. L. Stoddard & D. S. Jeffries & A. Lükewille & M. Forsius & J. Mannio & A. Wilander - 858-858 A 3,000-year record of penguin populations
by Liguang Sun & Zhouqing Xie & Junlin Zhao - 859-869 Glacial/interglacial variations in atmospheric carbon dioxide
by Daniel M. Sigman & Edward A. Boyle - 870-876 Vasoregulation by the β1 subunit of the calcium-activated potassium channel
by Robert Brenner & Guillermo J. Peréz & Adrian D. Bonev & Delrae M. Eckman & Jon C. Kosek & Steven W. Wiler & Andrew J. Patterson & Mark T. Nelson & Richard W. Aldrich - 877-879 Molecular emission from single-bubble sonoluminescence
by Yuri T. Didenko & William B. McNamara III & Kenneth S. Suslick - 880-883 Strain effects and phase transitions in photonic resonator crystals
by Harald Pier & Eli Kapon & Michael Moser - 883-885 Origin of ferromagnetic exchange interactions in a fullerene–organic compound
by Bakhyt Narymbetov & Ales Omerzu & Viktor V. Kabanov & Madoka Tokumoto & Hayao Kobayashi & Dragan Mihailovic - 885-887 Electrochemically induced annealing of stainless-steel surfaces
by G. T. Burstein & I. M. Hutchings & K. Sasaki - 887-890 Cooler winters as a possible cause of mass extinctions at the Eocene/Oligocene boundary
by Linda C. Ivany & William P. Patterson & Kyger C. Lohmann - 891-894 Non-chondritic distribution of the highly siderophile elements in mantle sulphides
by Olivier Alard & William L. Griffin & Jean Pierre Lorand & Simon E. Jackson & Suzanne Y. O'Reilly - 894-897 Starch grains reveal early root crop horticulture in the Panamanian tropical forest
by Dolores R. Piperno & Anthony J. Ranere & Irene Holst & Patricia Hansell - 897-900 Isolation of a 250 million-year-old halotolerant bacterium from a primary salt crystal
by Russell H. Vreeland & William D. Rosenzweig & Dennis W. Powers - 900-903 The proteins of linked genes evolve at similar rates
by Elizabeth J. B. Williams & Laurence D. Hurst - 903-906 Metapopulation dynamics of bubonic plague
by M. J. Keeling & C. A. Gilligan - 906-908 Involuntary orienting to sound improves visual perception
by John J. McDonald & Wolfgang A. Teder-Sälejärvi & Steven A. Hillyard - 908-913 Ghrelin induces adiposity in rodents
by Matthias Tschöp & David L. Smiley & Mark L. Heiman - 913-916 Repressor activity of Headless/Tcf3 is essential for vertebrate head formation
by Cheol-Hee Kim & Takaya Oda & Motoyuki Itoh & Di Jiang & Kristin Bruk Artinger & Settara C. Chandrasekharappa & Wolfgang Driever & Ajay B. Chitnis - 916-920 Development of Th1-type immune responses requires the type I cytokine receptor TCCR
by Qi Chen & Nico Ghilardi & Hua Wang & Thad Baker & Ming-Hong Xie & Austin Gurney & Iqbal S. Grewal & Frederic J. de Sauvage - 920-923 The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
by Ping Wei & Jun Zhang & Margarete Egan-Hafley & Shuguang Liang & David D. Moore - 923-926 Structure of a serpin–protease complex shows inhibition by deformation
by James A. Huntington & Randy J. Read & Robin W. Carrell - 926-926 Erratum: Intraprotein radical transfer during photoactivation of DNA photolyase
by Corrine Aubert & Marten H. Vos & Paul Mathis & André P. M. Eker & Klaus Brettel - 926-926 Erratum: Neural synchrony correlates with surface segregation rules
by Miguel Castelo-Branco & Rainer Goebel & Sergio Neuenschwander & Wolf Singer
October 2000, Volume 407, Issue 6805
- 661-661 Medicine Nobel goes to raiders of the brain's chemical secrets
by Alison Abbott - 662-662 Plastics that conduct win inventors chemistry prize
by David Adam - 662-662 Fathers of electronic revolution are rewarded
by Liesbeth Venema - 663-663 Gore and Bush back rise in science spending
by Macilwain Colin - 663-664 Project offers free mouse sequence
by Paul Smaglik & Alison Abbott - 664-664 Anger as Spain boosts R&D figures with defence money
by Xavier Bosch - 665-665 Ig Nobel glory for levitating frogs and collapsing toilets
by Steve Nadis - 665-665 Astrometry mission wins German approval
by Alison Abbott - 668-670 Science for art's sake
by Steve Nadis - 671-671 Poorly conducted (or reported) animal tests put humans at risk
by Victoria Hampshire - 671-671 Survival on the edge: the tube worm's strategy
by John D. Rummel - 671-671 Why don't creationists use private schools?
by Jeffrey M. Marcus & Joanne E. Seiff - 673-674 Activism, scientists and sociobiology
by David L. Hull - 674-675 Dowsing the human volcano
by Paul Crutzen - 675-676 Icy displays from before time
by Dale P. Cruikshank - 676-676 Science in culture
by Philip Ball - 677-677 A victim of truth
by Sunetra Gupta - 679-679 Win a Nobel prize!
by Vernor Vinge - 681-682 Making a potential difference
by George E. Blomgren - 682-683 Building blocks of movement
by Zoubin Ghahramani - 683-685 Seeds of doubt
by Peter D. Moore - 685-686 Stirring times in the Southern Ocean
by Sallie W. Chisholm - 687-689 Guarding against mutation
by Richard D. Kolodner - 689-690 Use it or lose it
by Robert D. Holt - 690-690 Daedalus
by David Jones - 691-692 Before striking gold in gold-ruby glass
by F. E. Wagner & S. Haslbeck & L. Stievano & S. Calogero & Q. A. Pankhurst & K. -P. Martinek - 692-693 Facultative worker policing in a wasp
by Kevin R. Foster & Francis L. W. Ratnieks - 693-694 Maternal effect of Hsf1 on reproductive success
by E. Christians & A. A. Davis & S. D. Thomas & I. J. Benjamin - 694-694 Coexistence and resource competition
by Per Lundberg & Esa Ranta & Veijo Kaitala & Niclas Jonzén - 694-694 reply: Coexistence and resource competition
by Jef Huisman & Franz J. Weissing