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Controlled growth factor release from synthetic extracellular matrices

Author

Listed:
  • Kuen Yong Lee

    (Departments of Biologic & Materials Sciences
    Chemical Engineering
    Biomedical Engineering)

  • Martin C. Peters

    (Biomedical Engineering)

  • Kenneth W. Anderson

    (Departments of Biologic & Materials Sciences
    University of Michigan)

  • David J. Mooney

    (Departments of Biologic & Materials Sciences
    Chemical Engineering
    Biomedical Engineering)

Abstract

Polymeric matrices can be used to grow new tissues and organs1,2, and the delivery of growth factors from these matrices is one method to regenerate tissues3,4. A problem with engineering tissues that exist in a mechanically dynamic environment, such as bone, muscle and blood vessels5,6, is that most drug delivery systems have been designed to operate under static conditions. We thought that polymeric matrices, which release growth factors in response to mechanical signals, might provide a new approach to guide tissue formation in mechanically stressed environments. Critical design features for this type of system include the ability to undergo repeated deformation, and a reversible binding of the protein growth factors to polymeric matrices to allow for responses to repeated stimuli. Here we report a model delivery system that can respond to mechanical signalling and upregulate the release of a growth factor to promote blood vessel formation. This approach may find a number of applications, including regeneration and engineering of new tissues and more general drug-delivery applications.

Suggested Citation

  • Kuen Yong Lee & Martin C. Peters & Kenneth W. Anderson & David J. Mooney, 2000. "Controlled growth factor release from synthetic extracellular matrices," Nature, Nature, vol. 408(6815), pages 998-1000, December.
    • Handle: RePEc:nat:nature:v:408:y:2000:i:6815:d:10.1038_35050141
    DOI: 10.1038/35050141
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    Cited by:

    1. William Whyte & Debkalpa Goswami & Sophie X. Wang & Yiling Fan & Niamh A. Ward & Ruth E. Levey & Rachel Beatty & Scott T. Robinson & Declan Sheppard & Raymond O’Connor & David S. Monahan & Lesley Tras, 2022. "Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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