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Conservation and elaboration of Hox gene regulation during evolution of the vertebrate head

Author

Listed:
  • Miguel Manzanares

    (MRC National Institute for Medical Research
    Instituto Cajal, CSIC)

  • Hiroshi Wada

    (Seto Marine Biological Laboratory, Kyoto University
    School of Animal and Microbial Sciences, The University of Reading)

  • Nobue Itasaki

    (MRC National Institute for Medical Research)

  • Paul A. Trainor

    (MRC National Institute for Medical Research)

  • Robb Krumlauf

    (MRC National Institute for Medical Research
    Stowers Institute for Medical Research)

  • Peter W. H. Holland

    (School of Animal and Microbial Sciences, The University of Reading)

Abstract

The comparison of Hox genes between vertebrates and their closest invertebrate relatives (amphioxus and ascidia) highlights two derived features of Hox genes in vertebrates: duplication of the Hox gene cluster1,2, and an elaboration of Hox expression patterns and roles compared with non-vertebrate chordates3,4,5,6,7,8. We have investigated how new expression domains and their associated developmental functions evolved, by testing the cis-regulatory activity of genomic DNA fragments from the cephalochordate amphioxus Hox cluster in transgenic mouse and chick embryos. Here we present evidence for the conservation of cis-regulatory mechanisms controlling gene expression in the neural tube for half a billion years of evolution, including a dependence on retinoic acid signalling. We also identify amphioxus Hox gene regulatory elements that drive spatially localized expression in vertebrate neural crest cells, in derivatives of neurogenic placodes and in branchial arches, despite the fact that cephalochordates lack both neural crest and neurogenic placodes. This implies an elaboration of cis-regulatory elements in the Hox gene cluster of vertebrate ancestors during the evolution of craniofacial patterning.

Suggested Citation

  • Miguel Manzanares & Hiroshi Wada & Nobue Itasaki & Paul A. Trainor & Robb Krumlauf & Peter W. H. Holland, 2000. "Conservation and elaboration of Hox gene regulation during evolution of the vertebrate head," Nature, Nature, vol. 408(6814), pages 854-857, December.
    • Handle: RePEc:nat:nature:v:408:y:2000:i:6814:d:10.1038_35048570
    DOI: 10.1038/35048570
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    Cited by:

    1. Alice M. H. Bedois & Hugo J. Parker & Andrew J. Price & Jason A. Morrison & Marianne E. Bronner & Robb Krumlauf, 2024. "Sea lamprey enlightens the origin of the coupling of retinoic acid signaling to vertebrate hindbrain segmentation," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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