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Genetic footprints of assortative mating in the Japanese population

Author

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  • Kenichi Yamamoto

    (Osaka University Graduate School of Medicine
    Osaka University Graduate School of Medicine
    Osaka University)

  • Kyuto Sonehara

    (Osaka University Graduate School of Medicine
    Osaka University)

  • Shinichi Namba

    (Osaka University Graduate School of Medicine)

  • Takahiro Konuma

    (Osaka University Graduate School of Medicine)

  • Hironori Masuko

    (University of Tsukuba)

  • Satoru Miyawaki

    (The University of Tokyo)

  • Yoichiro Kamatani

    (The University of Tokyo)

  • Nobuyuki Hizawa

    (University of Tsukuba)

  • Keiichi Ozono

    (Osaka University Graduate School of Medicine)

  • Loic Yengo

    (The University of Queensland)

  • Yukinori Okada

    (Osaka University Graduate School of Medicine
    Osaka University
    Osaka University
    RIKEN Center for Integrative Medical Sciences)

Abstract

Assortative mating (AM) is a pattern characterized by phenotypic similarities between mating partners. Detecting the evidence of AM has been challenging due to the lack of large-scale datasets that include phenotypic data on both partners, especially in populations of non-European ancestries. Gametic phase disequilibrium between trait-associated alleles is a signature of parental AM on a polygenic trait, which can be detected even without partner data. Here, using polygenic scores for 81 traits in the Japanese population using BioBank Japan Project genome-wide association studies data (n = 172,270), we found evidence of AM on the liability to type 2 diabetes and coronary artery disease, as well as on dietary habits. In cross-population comparison using United Kingdom Biobank data (n = 337,139) we found shared but heterogeneous impacts of AM between populations.

Suggested Citation

  • Kenichi Yamamoto & Kyuto Sonehara & Shinichi Namba & Takahiro Konuma & Hironori Masuko & Satoru Miyawaki & Yoichiro Kamatani & Nobuyuki Hizawa & Keiichi Ozono & Loic Yengo & Yukinori Okada, 2023. "Genetic footprints of assortative mating in the Japanese population," Nature Human Behaviour, Nature, vol. 7(1), pages 65-73, January.
    • Handle: RePEc:nat:nathum:v:7:y:2023:i:1:d:10.1038_s41562-022-01438-z
    DOI: 10.1038/s41562-022-01438-z
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