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GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits

Author

Listed:
  • Nana Matoba

    (Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
    University of North Carolina at Chapel Hill)

  • Masato Akiyama

    (Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
    Kyushu University)

  • Kazuyoshi Ishigaki

    (Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences)

  • Masahiro Kanai

    (Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
    Harvard Medical School)

  • Atsushi Takahashi

    (Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
    Research Institute, National Cerebral and Cardiovascular Center)

  • Yukihide Momozawa

    (Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences)

  • Shiro Ikegawa

    (Laboratory for Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences)

  • Masashi Ikeda

    (Fujita Health University School of Medicine)

  • Nakao Iwata

    (Fujita Health University School of Medicine)

  • Makoto Hirata

    (The University of Tokyo)

  • Koichi Matsuda

    (The University of Tokyo)

  • Yoshinori Murakami

    (The University of Tokyo)

  • Michiaki Kubo

    (RIKEN Center for Integrative Medical Sciences)

  • Yoichiro Kamatani

    (Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
    The University of Tokyo)

  • Yukinori Okada

    (Osaka University Graduate School of Medicine
    Osaka University
    Osaka University)

Abstract

Dietary habits are important factors in our lifestyle, and confer both susceptibility to and protection from a variety of human diseases. We performed genome-wide association studies for 13 dietary habits including consumption of alcohol (ever versus never drinkers and drinks per week), beverages (coffee, green tea and milk) and foods (yoghurt, cheese, natto, tofu, fish, small whole fish, vegetables and meat) in Japanese individuals (n = 58,610–165,084) collected by BioBank Japan, the nationwide hospital-based genome cohort. Significant associations were found in nine genetic loci (MCL1-ENSA, GCKR, AGR3-AHR, ADH1B, ALDH1B1, ALDH1A1, ALDH2, CYP1A2-CSK and ADORA2A-AS1) for 13 dietary traits (P

Suggested Citation

  • Nana Matoba & Masato Akiyama & Kazuyoshi Ishigaki & Masahiro Kanai & Atsushi Takahashi & Yukihide Momozawa & Shiro Ikegawa & Masashi Ikeda & Nakao Iwata & Makoto Hirata & Koichi Matsuda & Yoshinori Mu, 2020. "GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits," Nature Human Behaviour, Nature, vol. 4(3), pages 308-316, March.
    • Handle: RePEc:nat:nathum:v:4:y:2020:i:3:d:10.1038_s41562-019-0805-1
    DOI: 10.1038/s41562-019-0805-1
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    Cited by:

    1. Kenichi Yamamoto & Kyuto Sonehara & Shinichi Namba & Takahiro Konuma & Hironori Masuko & Satoru Miyawaki & Yoichiro Kamatani & Nobuyuki Hizawa & Keiichi Ozono & Loic Yengo & Yukinori Okada, 2023. "Genetic footprints of assortative mating in the Japanese population," Nature Human Behaviour, Nature, vol. 7(1), pages 65-73, January.

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