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VAP spatially stabilizes dendritic mitochondria to locally support synaptic plasticity

Author

Listed:
  • Ojasee Bapat

    (Max Planck Florida Institute for Neuroscience
    International Max Planck Research School for Synapses and Circuits)

  • Tejas Purimetla

    (Max Planck Florida Institute for Neuroscience
    Geisel School of Medicine at Dartmouth)

  • Sarah Kruessel

    (Max Planck Institute for Brain Research
    Johns Hopkins University School of Medicine)

  • Monil Shah

    (Max Planck Florida Institute for Neuroscience
    International Max Planck Research School for Synapses and Circuits)

  • Ruolin Fan

    (Max Planck Florida Institute for Neuroscience)

  • Christina Thum

    (Max Planck Institute for Brain Research)

  • Fiona Rupprecht

    (Max Planck Institute for Brain Research
    Max Planck Institute of Biophysics
    Thermo Fisher Diagnostics GmbH)

  • Julian D. Langer

    (Max Planck Institute for Brain Research
    Max Planck Institute of Biophysics)

  • Vidhya Rangaraju

    (Max Planck Florida Institute for Neuroscience)

Abstract

Synapses are pivotal sites of plasticity and memory formation. Consequently, synapses are energy consumption hotspots susceptible to dysfunction when their energy supplies are perturbed. Mitochondria are stabilized near synapses via the cytoskeleton and provide the local energy required for synaptic plasticity. However, the mechanisms that tether and stabilize mitochondria to support synaptic plasticity are unknown. We identified proteins exclusively tethering mitochondria to actin near postsynaptic spines. We find that VAP, the vesicle-associated membrane protein-associated protein implicated in amyotrophic lateral sclerosis, stabilizes mitochondria via actin near the spines. To test if the VAP-dependent stable mitochondrial compartments can locally support synaptic plasticity, we used two-photon glutamate uncaging for spine plasticity induction and investigated the induced and adjacent uninduced spines. We find VAP functions as a spatial stabilizer of mitochondrial compartments for up to ~60 min and as a spatial ruler determining the ~30 μm dendritic segment supported during synaptic plasticity.

Suggested Citation

  • Ojasee Bapat & Tejas Purimetla & Sarah Kruessel & Monil Shah & Ruolin Fan & Christina Thum & Fiona Rupprecht & Julian D. Langer & Vidhya Rangaraju, 2024. "VAP spatially stabilizes dendritic mitochondria to locally support synaptic plasticity," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44233-8
    DOI: 10.1038/s41467-023-44233-8
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    References listed on IDEAS

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    1. Masanori Matsuzaki & Naoki Honkura & Graham C. R. Ellis-Davies & Haruo Kasai, 2004. "Structural basis of long-term potentiation in single dendritic spines," Nature, Nature, vol. 429(6993), pages 761-766, June.
    2. Min Fu & Xinzhu Yu & Ju Lu & Yi Zuo, 2012. "Repetitive motor learning induces coordinated formation of clustered dendritic spines in vivo," Nature, Nature, vol. 483(7387), pages 92-95, March.
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