IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v408y2000i6812d10.1038_35046067.html
   My bibliography  Save this article

Calcium stores regulate the polarity and input specificity of synaptic modification

Author

Listed:
  • Makoto Nishiyama

    (University of California at San Diego
    New York University School of Medicine)

  • Kyonsoo Hong

    (University of California at San Diego
    New York University School of Medicine)

  • Katsuhiko Mikoshiba

    (Mikoshiba Calciosignal Net Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Corporation (JST))

  • Mu-ming Poo

    (University of California at San Diego
    Mikoshiba Calciosignal Net Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Corporation (JST))

  • Kunio Kato

    (Mikoshiba Calciosignal Net Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Corporation (JST))

Abstract

Activity-induced synaptic modification is essential for the development and plasticity of the nervous system1,2,3. Repetitive correlated activation of pre- and postsynaptic neurons can induce persistent enhancement or decrement of synaptic efficacy, commonly referred to as long-term potentiation or depression2,3(LTP or LTD). An important unresolved issue is whether and to what extent LTP and LTD are restricted to the activated synapses4,5,6,7,8. Here we show that, in the CA1 region of the hippocampus, reduction of postsynaptic calcium influx by partial blockade of NMDA (N-methyl-d-aspartate) receptors results in a conversion of LTP to LTD and a loss of input specificity normally associated with LTP, with LTD appearing at heterosynaptic inputs. The induction of LTD at homo- and heterosynaptic sites requires functional ryanodine receptors and inositol triphosphate (InsP3) receptors, respectively. Functional blockade or genetic deletion of type 1 InsP3 receptors led to a conversion of LTD to LTP and elimination of heterosynaptic LTD, whereas blocking ryanodine receptors eliminated only homosynaptic LTD. Thus, postsynaptic Ca2+, deriving from Ca2+ influx and differential release of Ca2+ from internal stores through ryanodine and InsP3 receptors, regulates both the polarity and input specificity of activity-induced synaptic modification.

Suggested Citation

  • Makoto Nishiyama & Kyonsoo Hong & Katsuhiko Mikoshiba & Mu-ming Poo & Kunio Kato, 2000. "Calcium stores regulate the polarity and input specificity of synaptic modification," Nature, Nature, vol. 408(6812), pages 584-588, November.
    • Handle: RePEc:nat:nature:v:408:y:2000:i:6812:d:10.1038_35046067
    DOI: 10.1038/35046067
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35046067
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/35046067?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Thomas E. Chater & Maximilian F. Eggl & Yukiko Goda & Tatjana Tchumatchenko, 2024. "Competitive processes shape multi-synapse plasticity along dendritic segments," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Yu, Haitao & Guo, Xinmeng & Wang, Jiang & Deng, Bin & Wei, Xile, 2015. "Vibrational resonance in adaptive small-world neuronal networks with spike-timing-dependent plasticity," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 436(C), pages 170-179.
    3. Dariusz Świetlik, 2018. "Simulations of Learning, Memory, and Forgetting Processes with Model of CA1 Region of the Hippocampus," Complexity, Hindawi, vol. 2018, pages 1-13, December.
    4. Pierre Yger & Kenneth D Harris, 2013. "The Convallis Rule for Unsupervised Learning in Cortical Networks," PLOS Computational Biology, Public Library of Science, vol. 9(10), pages 1-16, October.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:408:y:2000:i:6812:d:10.1038_35046067. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.