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Activation of CaMKII in single dendritic spines during long-term potentiation

Author

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  • Seok-Jin R. Lee

    (Duke University Medical Center, Durham, North Carolina 27710, USA)

  • Yasmin Escobedo-Lozoya

    (Duke University Medical Center, Durham, North Carolina 27710, USA)

  • Erzsebet M. Szatmari

    (Duke University Medical Center, Durham, North Carolina 27710, USA)

  • Ryohei Yasuda

    (Duke University Medical Center, Durham, North Carolina 27710, USA)

Abstract

Calcium/calmodulin-dependent kinase II (CaMKII) plays a central part in long-term potentiation (LTP), which underlies some forms of learning and memory. Here we monitored the spatiotemporal dynamics of CaMKII activation in individual dendritic spines during LTP using two-photon fluorescence lifetime imaging microscopy, in combination with two-photon glutamate uncaging. Induction of LTP and associated spine enlargement in single spines triggered transient (∼1 min) CaMKII activation restricted to the stimulated spines. CaMKII in spines was specifically activated by NMDA receptors and L-type voltage-sensitive calcium channels, presumably by nanodomain Ca2+ near the channels, in response to glutamate uncaging and depolarization, respectively. The high degree of compartmentalization and channel specificity of CaMKII signalling allow stimuli-specific spatiotemporal patterns of CaMKII signalling and may be important for synapse-specificity of synaptic plasticity.

Suggested Citation

  • Seok-Jin R. Lee & Yasmin Escobedo-Lozoya & Erzsebet M. Szatmari & Ryohei Yasuda, 2009. "Activation of CaMKII in single dendritic spines during long-term potentiation," Nature, Nature, vol. 458(7236), pages 299-304, March.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7236:d:10.1038_nature07842
    DOI: 10.1038/nature07842
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    Cited by:

    1. Thomas E. Chater & Maximilian F. Eggl & Yukiko Goda & Tatjana Tchumatchenko, 2024. "Competitive processes shape multi-synapse plasticity along dendritic segments," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Yoshihisa Kubota & M Neal Waxham, 2010. "Lobe Specific Ca2+-Calmodulin Nano-Domain in Neuronal Spines: A Single Molecule Level Analysis," PLOS Computational Biology, Public Library of Science, vol. 6(11), pages 1-21, November.
    3. Isabel Espadas & Jenna L. Wingfield & Yoshihisa Nakahata & Kaushik Chanda & Eddie Grinman & Ilika Ghosh & Karl E. Bauer & Bindu Raveendra & Michael A. Kiebler & Ryohei Yasuda & Vidhya Rangaraju & Sath, 2024. "Synaptically-targeted long non-coding RNA SLAMR promotes structural plasticity by increasing translation and CaMKII activity," Nature Communications, Nature, vol. 15(1), pages 1-24, December.

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