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Local, persistent activation of Rho GTPases during plasticity of single dendritic spines

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Listed:
  • Hideji Murakoshi

    (Department of Neurobiology,)

  • Hong Wang

    (Department of Neurobiology,)

  • Ryohei Yasuda

    (Department of Neurobiology,
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA)

Abstract

Rho GTPase activity and dendritic cell plasticity Even brief neuronal activity can result in long-term potentiation (LTP) of synapses, which is associated with enlargement of dendritic spines on the neuron at the receiving end of neurotransmission. Using live imaging of fluorescently tagged signalling proteins in individual spines, Ryohei Yasuda and colleagues show that transient activation of the Ca2+/calmodulin-dependent kinase (CaMKII) is translated into short-term versus long-term and long-range (dendritic) versus short-range (spine-confined) signalling, depending on which small GTPase of the Rho family is activated. The technique is bringing the study of the cellular bases of learning and memory down to the nanometre scale.

Suggested Citation

  • Hideji Murakoshi & Hong Wang & Ryohei Yasuda, 2011. "Local, persistent activation of Rho GTPases during plasticity of single dendritic spines," Nature, Nature, vol. 472(7341), pages 100-104, April.
    • Handle: RePEc:nat:nature:v:472:y:2011:i:7341:d:10.1038_nature09823
    DOI: 10.1038/nature09823
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    Cited by:

    1. Thomas E. Chater & Maximilian F. Eggl & Yukiko Goda & Tatjana Tchumatchenko, 2024. "Competitive processes shape multi-synapse plasticity along dendritic segments," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Zhiwei Xu & Erez Geron & Luis M. Pérez-Cuesta & Yang Bai & Wen-Biao Gan, 2023. "Generalized extinction of fear memory depends on co-allocation of synaptic plasticity in dendrites," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Prateek Kumar & Annie M. Goettemoeller & Claudia Espinosa-Garcia & Brendan R. Tobin & Ali Tfaily & Ruth S. Nelson & Aditya Natu & Eric B. Dammer & Juliet V. Santiago & Sneha Malepati & Lihong Cheng & , 2024. "Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer’s pathology," Nature Communications, Nature, vol. 15(1), pages 1-26, December.

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