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Adaptative survival of Aspergillus fumigatus to echinocandins arises from cell wall remodeling beyond β−1,3-glucan synthesis inhibition

Author

Listed:
  • Malitha C. Dickwella Widanage

    (Michigan State University
    National High Magnetic Field Laboratory)

  • Isha Gautam

    (Michigan State University)

  • Daipayan Sarkar

    (MSU-DOE Plant Research Laboratory)

  • Frederic Mentink-Vigier

    (National High Magnetic Field Laboratory)

  • Josh V. Vermaas

    (MSU-DOE Plant Research Laboratory
    Michigan State University)

  • Shi-You Ding

    (Michigan State University)

  • Andrew S. Lipton

    (Pacific Northwest National Laboratory)

  • Thierry Fontaine
  • Jean-Paul Latgé

    (University of Crete)

  • Ping Wang

    (Louisiana State University Health Sciences Center)

  • Tuo Wang

    (Michigan State University)

Abstract

Antifungal echinocandins inhibit the biosynthesis of β−1,3-glucan, a major and essential polysaccharide component of the fungal cell wall. However, the efficacy of echinocandins against the pathogen Aspergillus fumigatus is limited. Here, we use solid-state nuclear magnetic resonance (ssNMR) and other techniques to show that echinocandins induce dynamic changes in the assembly of mobile and rigid polymers within the A. fumigatus cell wall. The reduction of β−1,3-glucan induced by echinocandins is accompanied by a concurrent increase in levels of chitin, chitosan, and highly polymorphic α−1,3-glucans, whose physical association with chitin maintains cell wall integrity and modulates water permeability. The rearrangement of the macromolecular network is dynamic and controls the permeability and circulation of the drug throughout the cell wall. Thus, our results indicate that echinocandin treatment triggers compensatory rearrangements in the cell wall that may help A. fumigatus to tolerate the drugs’ antifungal effects.

Suggested Citation

  • Malitha C. Dickwella Widanage & Isha Gautam & Daipayan Sarkar & Frederic Mentink-Vigier & Josh V. Vermaas & Shi-You Ding & Andrew S. Lipton & Thierry Fontaine & Jean-Paul Latgé & Ping Wang & Tuo Wang, 2024. "Adaptative survival of Aspergillus fumigatus to echinocandins arises from cell wall remodeling beyond β−1,3-glucan synthesis inhibition," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-50799-8
    DOI: 10.1038/s41467-024-50799-8
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    References listed on IDEAS

    as
    1. Arnab Chakraborty & Liyanage D. Fernando & Wenxia Fang & Malitha C. Dickwella Widanage & Pingzhen Wei & Cheng Jin & Thierry Fontaine & Jean-Paul Latgé & Tuo Wang, 2021. "A molecular vision of fungal cell wall organization by functional genomics and solid-state NMR," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Liyanage D. Fernando & Yordanis Pérez-Llano & Malitha C. Dickwella Widanage & Anand Jacob & Liliana Martínez-Ávila & Andrew S. Lipton & Nina Gunde-Cimerman & Jean-Paul Latgé & Ramón Alberto Batista-Ga, 2023. "Structural adaptation of fungal cell wall in hypersaline environment," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    3. Charles R. Harris & K. Jarrod Millman & Stéfan J. Walt & Ralf Gommers & Pauli Virtanen & David Cournapeau & Eric Wieser & Julian Taylor & Sebastian Berg & Nathaniel J. Smith & Robert Kern & Matti Picu, 2020. "Array programming with NumPy," Nature, Nature, vol. 585(7825), pages 357-362, September.
    4. Alex Kirui & Wancheng Zhao & Fabien Deligey & Hui Yang & Xue Kang & Frederic Mentink-Vigier & Tuo Wang, 2022. "Carbohydrate-aromatic interface and molecular architecture of lignocellulose," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    5. Xue Kang & Alex Kirui & Artur Muszyński & Malitha C. Dickwella Widanage & Adrian Chen & Parastoo Azadi & Ping Wang & Frederic Mentink-Vigier & Tuo Wang, 2018. "Molecular architecture of fungal cell walls revealed by solid-state NMR," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    6. Thomas J. Simmons & Jenny C. Mortimer & Oigres D. Bernardinelli & Ann-Christin Pöppler & Steven P. Brown & Eduardo R. deAzevedo & Ray Dupree & Paul Dupree, 2016. "Folding of xylan onto cellulose fibrils in plant cell walls revealed by solid-state NMR," Nature Communications, Nature, vol. 7(1), pages 1-9, December.
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