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Structural adaptation of fungal cell wall in hypersaline environment

Author

Listed:
  • Liyanage D. Fernando

    (Michigan State University
    University of Georgia)

  • Yordanis Pérez-Llano

    (Universidad Autónoma del Estado de Morelos)

  • Malitha C. Dickwella Widanage

    (Michigan State University
    University of Michigan)

  • Anand Jacob

    (Michigan State University)

  • Liliana Martínez-Ávila

    (Universidad Autónoma del Estado de Morelos)

  • Andrew S. Lipton

    (Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory)

  • Nina Gunde-Cimerman

    (University of Ljubljana)

  • Jean-Paul Latgé

    (University of Crete
    University of Angers)

  • Ramón Alberto Batista-García

    (Universidad Autónoma del Estado de Morelos)

  • Tuo Wang

    (Michigan State University)

Abstract

Halophilic fungi thrive in hypersaline habitats and face a range of extreme conditions. These fungal species have gained considerable attention due to their potential applications in harsh industrial processes, such as bioremediation and fermentation under unfavorable conditions of hypersalinity, low water activity, and extreme pH. However, the role of the cell wall in surviving these environmental conditions remains unclear. Here we employ solid-state NMR spectroscopy to compare the cell wall architecture of Aspergillus sydowii across salinity gradients. Analyses of intact cells reveal that A. sydowii cell walls contain a rigid core comprising chitin, β-glucan, and chitosan, shielded by a surface shell composed of galactomannan and galactosaminogalactan. When exposed to hypersaline conditions, A. sydowii enhances chitin biosynthesis and incorporates α-glucan to create thick, stiff, and hydrophobic cell walls. Such structural rearrangements enable the fungus to adapt to both hypersaline and salt-deprived conditions, providing a robust mechanism for withstanding external stress. These molecular principles can aid in the optimization of halophilic strains for biotechnology applications.

Suggested Citation

  • Liyanage D. Fernando & Yordanis Pérez-Llano & Malitha C. Dickwella Widanage & Anand Jacob & Liliana Martínez-Ávila & Andrew S. Lipton & Nina Gunde-Cimerman & Jean-Paul Latgé & Ramón Alberto Batista-Ga, 2023. "Structural adaptation of fungal cell wall in hypersaline environment," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42693-6
    DOI: 10.1038/s41467-023-42693-6
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    References listed on IDEAS

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    Cited by:

    1. Malitha C. Dickwella Widanage & Isha Gautam & Daipayan Sarkar & Frederic Mentink-Vigier & Josh V. Vermaas & Shi-You Ding & Andrew S. Lipton & Thierry Fontaine & Jean-Paul Latgé & Ping Wang & Tuo Wang, 2024. "Adaptative survival of Aspergillus fumigatus to echinocandins arises from cell wall remodeling beyond β−1,3-glucan synthesis inhibition," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Luis Andrés Yarzábal Rodríguez & Peggy Elizabeth Álvarez Gutiérrez & Nina Gunde-Cimerman & Jimmy Casto Ciancas Jiménez & Adrián Gutiérrez-Cepeda & Ana María Fernández Ocaña & Ramón Alberto Batista-Gar, 2024. "Exploring extremophilic fungi in soil mycobiome for sustainable agriculture amid global change," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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