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Magnetosensitivity of tightly bound radical pairs in cryptochrome is enabled by the quantum Zeno effect

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Listed:
  • Matt C. J. Denton

    (University of Exeter
    University of Exeter)

  • Luke D. Smith

    (University of Exeter
    University of Exeter)

  • Wenhao Xu

    (University of Exeter
    University of Exeter)

  • Jodeci Pugsley

    (University of Exeter
    University of Exeter)

  • Amelia Toghill

    (University of Exeter
    University of Exeter)

  • Daniel R. Kattnig

    (University of Exeter
    University of Exeter)

Abstract

The radical pair mechanism accounts for the magnetic field sensitivity of a large class of chemical reactions and is hypothesised to underpin numerous magnetosensitive traits in biology, including the avian compass. Traditionally, magnetic field sensitivity in this mechanism is attributed to radical pairs with weakly interacting, well-separated electrons; closely bound pairs were considered unresponsive to weak fields due to arrested spin dynamics. In this study, we challenge this view by examining the FAD-superoxide radical pair within cryptochrome, a protein hypothesised to function as a biological magnetosensor. Contrary to expectations, we find that this tightly bound radical pair can respond to Earth-strength magnetic fields, provided that the recombination reaction is strongly asymmetric—a scenario invoking the quantum Zeno effect. These findings present a plausible mechanism for weak magnetic field effects in biology, suggesting that even closely associated radical pairs, like those involving superoxide, may play a role in magnetic sensing.

Suggested Citation

  • Matt C. J. Denton & Luke D. Smith & Wenhao Xu & Jodeci Pugsley & Amelia Toghill & Daniel R. Kattnig, 2024. "Magnetosensitivity of tightly bound radical pairs in cryptochrome is enabled by the quantum Zeno effect," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-55124-x
    DOI: 10.1038/s41467-024-55124-x
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    2. Jingjing Xu & Lauren E. Jarocha & Tilo Zollitsch & Marcin Konowalczyk & Kevin B. Henbest & Sabine Richert & Matthew J. Golesworthy & Jessica Schmidt & Victoire Déjean & Daniel J. C. Sowood & Marco Bas, 2021. "Magnetic sensitivity of cryptochrome 4 from a migratory songbird," Nature, Nature, vol. 594(7864), pages 535-540, June.
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