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A biodegradable and flexible neural interface for transdermal optoelectronic modulation and regeneration of peripheral nerves

Author

Listed:
  • Pengcheng Sun

    (Tsinghua University)

  • Chaochao Li

    (Key Laboratory of Musculoskeletal Trauma and Injuries PLA)

  • Can Yang

    (Tsinghua University)

  • Mengchun Sun

    (Key Laboratory of Musculoskeletal Trauma and Injuries PLA)

  • Hanqing Hou

    (Tsinghua University)

  • Yanjun Guan

    (Key Laboratory of Musculoskeletal Trauma and Injuries PLA)

  • Jinger Chen

    (Tsinghua University)

  • Shangbin Liu

    (Tsinghua University)

  • Kuntao Chen

    (Tsinghua University)

  • Yuan Ma

    (Tsinghua University)

  • Yunxiang Huang

    (Dartmouth College)

  • Xiangling Li

    (Key Laboratory of Musculoskeletal Trauma and Injuries PLA
    Huazhong University of Science and Technology)

  • Huachun Wang

    (Shenzhen Campus of Sun Yat-sen University)

  • Liu Wang

    (Beihang University
    Beihang University)

  • Shengfeng Chen

    (Key Laboratory of Musculoskeletal Trauma and Injuries PLA)

  • Haofeng Cheng

    (Key Laboratory of Musculoskeletal Trauma and Injuries PLA)

  • Wei Xiong

    (Chinese Institute for Brain Research)

  • Xing Sheng

    (Tsinghua University
    Tsinghua University
    Tsinghua University)

  • Milin Zhang

    (Tsinghua University)

  • Jiang Peng

    (Key Laboratory of Musculoskeletal Trauma and Injuries PLA
    Nantong University)

  • Shirong Wang

    (MegaRobo Technologies Co. ltd)

  • Yu Wang

    (Key Laboratory of Musculoskeletal Trauma and Injuries PLA
    Nantong University)

  • Lan Yin

    (Tsinghua University)

Abstract

Optoelectronic neural interfaces can leverage the photovoltaic effect to convert light into electrical current, inducing charge redistribution and enabling nerve stimulation. This method offers a non-genetic and remote approach for neuromodulation. Developing biodegradable and efficient optoelectronic neural interfaces is important for achieving transdermal stimulation while minimizing infection risks associated with device retrieval, thereby maximizing therapeutic outcomes. We propose a biodegradable, flexible, and miniaturized silicon-based neural interface capable of transdermal optoelectronic stimulation for neural modulation and nerve regeneration. Enhancing the device interface with thin-film molybdenum significantly improves the efficacy of neural stimulation. Our study demonstrates successful activation of the sciatic nerve in rodents and the facial nerve in rabbits. Moreover, transdermal optoelectronic stimulation accelerates the functional recovery of injured facial nerves.

Suggested Citation

  • Pengcheng Sun & Chaochao Li & Can Yang & Mengchun Sun & Hanqing Hou & Yanjun Guan & Jinger Chen & Shangbin Liu & Kuntao Chen & Yuan Ma & Yunxiang Huang & Xiangling Li & Huachun Wang & Liu Wang & Sheng, 2024. "A biodegradable and flexible neural interface for transdermal optoelectronic modulation and regeneration of peripheral nerves," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49166-4
    DOI: 10.1038/s41467-024-49166-4
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    References listed on IDEAS

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