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POLYRETINA restores light responses in vivo in blind Göttingen minipigs

Author

Listed:
  • Paola Vagni

    (École Polytechnique Fédérale de Lausanne)

  • Marta Jole Ildelfonsa Airaghi Leccardi

    (École Polytechnique Fédérale de Lausanne)

  • Charles-Henri Vila

    (École Polytechnique Fédérale de Lausanne)

  • Elodie Geneviève Zollinger

    (École Polytechnique Fédérale de Lausanne)

  • Golnaz Sherafatipour

    (École Polytechnique Fédérale de Lausanne)

  • Thomas J. Wolfensberger

    (University of Lausanne, Hôpital Ophtalmique Jules-Gonin, Fondation Asile des Aveugles)

  • Diego Ghezzi

    (École Polytechnique Fédérale de Lausanne)

Abstract

Retinal prostheses hold the potential for artificial vision in blind people affected by incurable diseases of the outer retinal layer. Available technologies provide only a small field of view: a significant limitation for totally blind people. To overcome this problem, we recently proposed a large and high-density photovoltaic epiretinal device, known as POLYRETINA. Here, we report the in vivo assessment of POLYRETINA. First, we characterise a model of chemically-induced blindness in Göttingen minipigs. Then, we develop and test a minimally invasive injection procedure to insert the large epiretinal implant into the eye. Last, we show that POLYRETINA restores light-evoked cortical responses in blind animals at safe irradiance levels. These results indicate that POLYRETINA holds the potential for artificial vision in totally blind patients affected by retinitis pigmentosa.

Suggested Citation

  • Paola Vagni & Marta Jole Ildelfonsa Airaghi Leccardi & Charles-Henri Vila & Elodie Geneviève Zollinger & Golnaz Sherafatipour & Thomas J. Wolfensberger & Diego Ghezzi, 2022. "POLYRETINA restores light responses in vivo in blind Göttingen minipigs," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31180-z
    DOI: 10.1038/s41467-022-31180-z
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    References listed on IDEAS

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    1. Jing Tang & Nan Qin & Yan Chong & Yupu Diao & Yiliguma & Zhexuan Wang & Tian Xue & Min Jiang & Jiayi Zhang & Gengfeng Zheng, 2018. "Nanowire arrays restore vision in blind mice," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
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    Cited by:

    1. Franklin Leong & Babak Rahmani & Demetri Psaltis & Christophe Moser & Diego Ghezzi, 2024. "An actor-model framework for visual sensory encoding," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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