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A biodegradable and restorative peripheral neural interface for the interrogation of neuropathic injuries

Author

Listed:
  • Liu Wang

    (Beihang University
    Beihang University
    Beihang University
    Beihang University)

  • Tieyuan Zhang

    (Chinese PLA General Hospital
    Chinese PLA General Hospital
    Chinese PLA General Hospital)

  • Jiaxin Lei

    (Tsinghua University)

  • Shirong Wang

    (MegaRobo Technologies Co. ltd)

  • Yanjun Guan

    (Chinese PLA General Hospital
    Chinese PLA General Hospital
    Chinese PLA General Hospital)

  • Kuntao Chen

    (Tsinghua University)

  • Chaochao Li

    (Chinese PLA General Hospital
    Chinese PLA General Hospital
    Chinese PLA General Hospital)

  • Yahao Song

    (Tsinghua University)

  • Weining Li

    (Tsinghua University)

  • Shimeng Wang

    (Tsinghua University)

  • Zhibo Jia

    (Chinese PLA General Hospital
    Chinese PLA General Hospital
    Chinese PLA General Hospital)

  • Shengfeng Chen

    (Chinese PLA General Hospital
    Chinese PLA General Hospital
    Chinese PLA General Hospital)

  • Jun Bai

    (Chinese PLA General Hospital
    Chinese PLA General Hospital
    Chinese PLA General Hospital)

  • Bingbing Yu

    (Tsinghua University)

  • Can Yang

    (Tsinghua University)

  • Pengcheng Sun

    (Tsinghua University)

  • Qingyun Wang

    (Beihang University)

  • Xing Sheng

    (Tsinghua University
    Tsinghua University
    Tsinghua University
    Tsinghua University)

  • Jiang Peng

    (Chinese PLA General Hospital
    Chinese PLA General Hospital
    Chinese PLA General Hospital)

  • Yubo Fan

    (Beihang University
    Beihang University
    Beihang University
    Beihang University)

  • Lizhen Wang

    (Beihang University
    Beihang University
    Beihang University
    Beihang University)

  • Milin Zhang

    (Tsinghua University)

  • Yu Wang

    (Chinese PLA General Hospital
    Chinese PLA General Hospital
    Chinese PLA General Hospital)

  • Lan Yin

    (Tsinghua University
    Tsinghua University
    Tsinghua University)

Abstract

Monitoring the early-stage healing of severe traumatic nerve injuries is essential to gather physiological and pathological information for timely interventions and optimal clinical outcomes. Traditional diagnostic methods relying on physical examinations, imaging tools, and intraoperative electrophysiological testing present great challenges in continuous and remote monitoring. While implantable peripheral nerve interfaces provide direct access to nerve fibers for precise interrogation and modulation, conventional non-degradable designs pose limited utilization in nerve injury rehabilitation. Here, we introduce a biodegradable and restorative neural interface for wireless real-time tracking and recovery of long-gap nerve injuries. Leveraging machine learning techniques, this electronic platform deciphers nerve recovery status and identifies traumatic neuroma formation at the early phase, enabling timely intervention and significantly improved therapeutic outcomes. The biodegradable nature of the device eliminates the need for retrieval procedures, reducing infection risks and secondary tissue damage. This research sheds light on bioresorbable multifunctional peripheral nerve interfaces for probing neuropathic injuries, offering vital information for early diagnosis and therapeutic intervention.

Suggested Citation

  • Liu Wang & Tieyuan Zhang & Jiaxin Lei & Shirong Wang & Yanjun Guan & Kuntao Chen & Chaochao Li & Yahao Song & Weining Li & Shimeng Wang & Zhibo Jia & Shengfeng Chen & Jun Bai & Bingbing Yu & Can Yang , 2025. "A biodegradable and restorative peripheral neural interface for the interrogation of neuropathic injuries," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
  • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-56089-1
    DOI: 10.1038/s41467-025-56089-1
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    References listed on IDEAS

    as
    1. Seung-Kyun Kang & Rory K. J. Murphy & Suk-Won Hwang & Seung Min Lee & Daniel V. Harburg & Neil A. Krueger & Jiho Shin & Paul Gamble & Huanyu Cheng & Sooyoun Yu & Zhuangjian Liu & Jordan G. McCall & Ma, 2016. "Bioresorbable silicon electronic sensors for the brain," Nature, Nature, vol. 530(7588), pages 71-76, February.
    2. Pengcheng Sun & Chaochao Li & Can Yang & Mengchun Sun & Hanqing Hou & Yanjun Guan & Jinger Chen & Shangbin Liu & Kuntao Chen & Yuan Ma & Yunxiang Huang & Xiangling Li & Huachun Wang & Liu Wang & Sheng, 2024. "A biodegradable and flexible neural interface for transdermal optoelectronic modulation and regeneration of peripheral nerves," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
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