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AI-enabled, implantable, multichannel wireless telemetry for photodynamic therapy

Author

Listed:
  • Woo Seok Kim

    (Texas A&M University)

  • M. Ibrahim Khot

    (University of Leeds)

  • Hyun-Myung Woo

    (Texas A&M University)

  • Sungcheol Hong

    (Texas A&M University)

  • Dong-Hyun Baek

    (Sun Moon University)

  • Thomas Maisey

    (University of Leeds)

  • Brandon Daniels

    (Texas A&M University)

  • P. Louise Coletta

    (University of Leeds)

  • Byung-Jun Yoon

    (Texas A&M University
    Brookhaven National Laboratory)

  • David G. Jayne

    (University of Leeds)

  • Sung Il Park

    (Texas A&M University
    Texas A&M University)

Abstract

Photodynamic therapy (PDT) offers several advantages for treating cancers, but its efficacy is highly dependent on light delivery to activate a photosensitizer. Advances in wireless technologies enable remote delivery of light to tumors, but suffer from key limitations, including low levels of tissue penetration and photosensitizer activation. Here, we introduce DeepLabCut (DLC)-informed low-power wireless telemetry with an integrated thermal/light simulation platform that overcomes the above constraints. The simulator produces an optimized combination of wavelengths and light sources, and DLC-assisted wireless telemetry uses the parameters from the simulator to enable adequate illumination of tumors through high-throughput (

Suggested Citation

  • Woo Seok Kim & M. Ibrahim Khot & Hyun-Myung Woo & Sungcheol Hong & Dong-Hyun Baek & Thomas Maisey & Brandon Daniels & P. Louise Coletta & Byung-Jun Yoon & David G. Jayne & Sung Il Park, 2022. "AI-enabled, implantable, multichannel wireless telemetry for photodynamic therapy," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29878-1
    DOI: 10.1038/s41467-022-29878-1
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    References listed on IDEAS

    as
    1. Aaron D. Mickle & Sang Min Won & Kyung Nim Noh & Jangyeol Yoon & Kathleen W. Meacham & Yeguang Xue & Lisa A. McIlvried & Bryan A. Copits & Vijay K. Samineni & Kaitlyn E. Crawford & Do Hoon Kim & Paulo, 2019. "A wireless closed-loop system for optogenetic peripheral neuromodulation," Nature, Nature, vol. 565(7739), pages 361-365, January.
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