IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-28472-9.html
   My bibliography  Save this article

An optogenetic approach for regulating human parathyroid hormone secretion

Author

Listed:
  • Yunhui Liu

    (Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions
    University of Chinese Academy of Sciences)

  • Lu Zhang

    (Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions
    The University of Hong Kong)

  • Nan Hu

    (The Second Clinical Medical College of Jinan University)

  • Jie Shao

    (Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions
    University of Chinese Academy of Sciences)

  • Dazhi Yang

    (Huazhong University of Science and Technology)

  • Changshun Ruan

    (Chinese Academy of Sciences (CAS))

  • Shishu Huang

    (West China Hospital of Sichuan University)

  • Liping Wang

    (Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions)

  • William W. Lu

    (The University of Hong Kong)

  • Xinzhou Zhang

    (The Second Clinical Medical College of Jinan University)

  • Fan Yang

    (Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions
    University of Chinese Academy of Sciences)

Abstract

Parathyroid hormone (PTH) plays crucial role in maintaining calcium and phosphorus homeostasis. In the progression of secondary hyperparathyroidism (SHPT), expression of calcium-sensing receptors (CaSR) in the parathyroid gland decreases, which leads to persistent hypersecretion of PTH. How to precisely manipulate PTH secretion in parathyroid tissue and underlying molecular mechanism is not clear. Here, we establish an optogenetic approach that bypasses CaSR to inhibit PTH secretion in human hyperplastic parathyroid cells. We found that optogenetic stimulation elevates intracellular calcium, inhibits both PTH synthesis and secretion in human parathyroid cells. Long-term pulsatile PTH secretion induced by light stimulation prevented hyperplastic parathyroid tissue-induced bone loss by influencing the bone remodeling in mice. The effects are mediated by light stimulation of opsin expressing parathyroid cells and other type of cells in parathyroid tissue. Our study provides a strategy to regulate release of PTH and associated bone loss of SHPT through an optogenetic approach.

Suggested Citation

  • Yunhui Liu & Lu Zhang & Nan Hu & Jie Shao & Dazhi Yang & Changshun Ruan & Shishu Huang & Liping Wang & William W. Lu & Xinzhou Zhang & Fan Yang, 2022. "An optogenetic approach for regulating human parathyroid hormone secretion," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28472-9
    DOI: 10.1038/s41467-022-28472-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-28472-9
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-022-28472-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Sivanandane Sittadjody & Justin M. Saul & John P. McQuilling & Sunyoung Joo & Thomas C. Register & James J. Yoo & Anthony Atala & Emmanuel C. Opara, 2017. "In vivo transplantation of 3D encapsulated ovarian constructs in rats corrects abnormalities of ovarian failure," Nature Communications, Nature, vol. 8(1), pages 1-13, December.
    2. Aaron D. Mickle & Sang Min Won & Kyung Nim Noh & Jangyeol Yoon & Kathleen W. Meacham & Yeguang Xue & Lisa A. McIlvried & Bryan A. Copits & Vijay K. Samineni & Kaitlyn E. Crawford & Do Hoon Kim & Paulo, 2019. "A wireless closed-loop system for optogenetic peripheral neuromodulation," Nature, Nature, vol. 565(7739), pages 361-365, January.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Tong Li & Zhidong Wei & Fei Jin & Yongjiu Yuan & Weiying Zheng & Lili Qian & Hongbo Wang & Lisha Hua & Juan Ma & Huanhuan Zhang & Huaduo Gu & Michael G. Irwin & Ting Wang & Steven Wang & Zuankai Wang , 2023. "Soft ferroelectret ultrasound receiver for targeted peripheral neuromodulation," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Alp Timucin Toymus & Umut Can Yener & Emine Bardakci & Özgür Deniz Temel & Ersin Koseoglu & Dincay Akcoren & Burak Eminoglu & Mohsin Ali & Rasim Kilic & Tufan Tarcan & Levent Beker, 2024. "An integrated and flexible ultrasonic device for continuous bladder volume monitoring," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    3. Alban Guesdon-Vennerie & Patrick Couvreur & Fatoumia Ali & Frédéric Pouzoulet & Christophe Roulin & Immaculada Martínez-Rovira & Guillaume Bernadat & François-Xavier Legrand & Claudie Bourgaux & Cyril, 2022. "Breaking photoswitch activation depth limit using ionising radiation stimuli adapted to clinical application," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Jinhong Park & Duhwan Seong & Yong Jun Park & Sang Hyeok Park & Hyunjin Jung & Yewon Kim & Hyoung Won Baac & Mikyung Shin & Seunghyun Lee & Minbaek Lee & Donghee Son, 2022. "Reversible electrical percolation in a stretchable and self-healable silver-gradient nanocomposite bilayer," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    5. Woo Seok Kim & M. Ibrahim Khot & Hyun-Myung Woo & Sungcheol Hong & Dong-Hyun Baek & Thomas Maisey & Brandon Daniels & P. Louise Coletta & Byung-Jun Yoon & David G. Jayne & Sung Il Park, 2022. "AI-enabled, implantable, multichannel wireless telemetry for photodynamic therapy," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    6. Cheng Yang & Qianni Wu & Junqing Liu & Jingshan Mo & Xiangling Li & Chengduan Yang & Ziqi Liu & Jingbo Yang & Lelun Jiang & Weirong Chen & Hui-jiuan Chen & Ji Wang & Xi Xie, 2022. "Intelligent wireless theranostic contact lens for electrical sensing and regulation of intraocular pressure," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    7. Pengcheng Sun & Chaochao Li & Can Yang & Mengchun Sun & Hanqing Hou & Yanjun Guan & Jinger Chen & Shangbin Liu & Kuntao Chen & Yuan Ma & Yunxiang Huang & Xiangling Li & Huachun Wang & Liu Wang & Sheng, 2024. "A biodegradable and flexible neural interface for transdermal optoelectronic modulation and regeneration of peripheral nerves," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    8. Kyowon Kang & Seongryeol Ye & Chanho Jeong & Jinmo Jeong & Yeong-sinn Ye & Jin-Young Jeong & Yu-Jin Kim & Selin Lim & Tae Hee Kim & Kyung Yeun Kim & Jong Uk Kim & Gwan In Kim & Do Hoon Chun & Kiho Kim, 2024. "Bionic artificial skin with a fully implantable wireless tactile sensory system for wound healing and restoring skin tactile function," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28472-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.