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Intelligent wireless theranostic contact lens for electrical sensing and regulation of intraocular pressure

Author

Listed:
  • Cheng Yang

    (Sun Yat-Sen University)

  • Qianni Wu

    (Sun Yat-Sen University)

  • Junqing Liu

    (the First Affiliated Hospital of Jinan University)

  • Jingshan Mo

    (Sun Yat-Sen University)

  • Xiangling Li

    (Sun Yat-Sen University
    Sun Yat-Sen University)

  • Chengduan Yang

    (Sun Yat-Sen University
    Sun Yat-Sen University)

  • Ziqi Liu

    (Sun Yat-Sen University)

  • Jingbo Yang

    (Sun Yat-Sen University
    Sun Yat-Sen University)

  • Lelun Jiang

    (Sun Yat-Sen University)

  • Weirong Chen

    (Sun Yat-Sen University)

  • Hui-jiuan Chen

    (Sun Yat-Sen University)

  • Ji Wang

    (Sun Yat-Sen University)

  • Xi Xie

    (Sun Yat-Sen University
    Sun Yat-Sen University)

Abstract

Engineering wearable devices that can wirelessly track intraocular pressure and offer feedback-medicine administrations are highly desirable for glaucoma treatments, yet remain challenging due to issues of limited sizes, wireless operations, and wireless cross-coupling. Here, we present an integrated wireless theranostic contact lens for in situ electrical sensing of intraocular pressure and on-demand anti-glaucoma drug delivery. The wireless theranostic contact lens utilizes a highly compact structural design, which enables high-degreed integration and frequency separation on the curved and limited surface of contact lens. The wireless intraocular pressure sensing modulus could ultra-sensitively detect intraocular pressure fluctuations, due to the unique cantilever configuration design of capacitive sensing circuit. The drug delivery modulus employs an efficient wireless power transfer circuit, to trigger delivery of anti-glaucoma drug into aqueous chamber via iontophoresis. The minimally invasive, smart, wireless and theranostic features endow the wireless theranostic contact lens as a highly promising system for glaucoma treatments.

Suggested Citation

  • Cheng Yang & Qianni Wu & Junqing Liu & Jingshan Mo & Xiangling Li & Chengduan Yang & Ziqi Liu & Jingbo Yang & Lelun Jiang & Weirong Chen & Hui-jiuan Chen & Ji Wang & Xi Xie, 2022. "Intelligent wireless theranostic contact lens for electrical sensing and regulation of intraocular pressure," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29860-x
    DOI: 10.1038/s41467-022-29860-x
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    References listed on IDEAS

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    1. Aaron D. Mickle & Sang Min Won & Kyung Nim Noh & Jangyeol Yoon & Kathleen W. Meacham & Yeguang Xue & Lisa A. McIlvried & Bryan A. Copits & Vijay K. Samineni & Kaitlyn E. Crawford & Do Hoon Kim & Paulo, 2019. "A wireless closed-loop system for optogenetic peripheral neuromodulation," Nature, Nature, vol. 565(7739), pages 361-365, January.
    2. Joohee Kim & Minji Kim & Mi-Sun Lee & Kukjoo Kim & Sangyoon Ji & Yun-Tae Kim & Jihun Park & Kyungmin Na & Kwi-Hyun Bae & Hong Kyun Kim & Franklin Bien & Chang Young Lee & Jang-Ung Park, 2017. "Wearable smart sensor systems integrated on soft contact lenses for wireless ocular diagnostics," Nature Communications, Nature, vol. 8(1), pages 1-8, April.
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    Cited by:

    1. Hengtian Zhu & Huan Yang & Siqi Xu & Yuanyuan Ma & Shugeng Zhu & Zhengyi Mao & Weiwei Chen & Zizhong Hu & Rongrong Pan & Yurui Xu & Yifeng Xiong & Ye Chen & Yanqing Lu & Xinghai Ning & Dechen Jiang & , 2024. "Frequency-encoded eye tracking smart contact lens for human–machine interaction," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Yuxiang Shi & Peng Yang & Rui Lei & Zhaoqi Liu & Xuanyi Dong & Xinglin Tao & Xiangcheng Chu & Zhong Lin Wang & Xiangyu Chen, 2023. "Eye tracking and eye expression decoding based on transparent, flexible and ultra-persistent electrostatic interface," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. Shangda Qu & Lin Sun & Song Zhang & Jiaqi Liu & Yue Li & Junchi Liu & Wentao Xu, 2023. "An artificially-intelligent cornea with tactile sensation enables sensory expansion and interaction," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. Weijia Liu & Zhijian Du & Zhongyi Duan & La Li & Guozhen Shen, 2024. "Neuroprosthetic contact lens enabled sensorimotor system for point-of-care monitoring and feedback of intraocular pressure," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    5. Jie Li & Fan Zhang & Xiaobin Xia & Kaihang Zhang & Jianhui Wu & Yulu Liu & Chi Zhang & Xinyu Cai & Jiaqi Lu & Liangquan Xu & Rui Wan & Dinku Hazarika & Weipeng Xuan & Jinkai Chen & Zhen Cao & Yubo Li , 2024. "An ultrasensitive multimodal intracranial pressure biotelemetric system enabled by exceptional point and iontronics," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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