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Nanowire arrays restore vision in blind mice

Author

Listed:
  • Jing Tang

    (Fudan University)

  • Nan Qin

    (Fudan University)

  • Yan Chong

    (Fudan University)

  • Yupu Diao

    (Fudan University)

  • Yiliguma

    (Fudan University)

  • Zhexuan Wang

    (Fudan University)

  • Tian Xue

    (University of Science and Technology of China)

  • Min Jiang

    (Fudan University)

  • Jiayi Zhang

    (Fudan University)

  • Gengfeng Zheng

    (Fudan University)

Abstract

The restoration of light response with complex spatiotemporal features in retinal degenerative diseases towards retinal prosthesis has proven to be a considerable challenge over the past decades. Herein, inspired by the structure and function of photoreceptors in retinas, we develop artificial photoreceptors based on gold nanoparticle-decorated titania nanowire arrays, for restoration of visual responses in the blind mice with degenerated photoreceptors. Green, blue and near UV light responses in the retinal ganglion cells (RGCs) are restored with a spatial resolution better than 100 µm. ON responses in RGCs are blocked by glutamatergic antagonists, suggesting functional preservation of the remaining retinal circuits. Moreover, neurons in the primary visual cortex respond to light after subretinal implant of nanowire arrays. Improvement in pupillary light reflex suggests the behavioral recovery of light sensitivity. Our study will shed light on the development of a new generation of optoelectronic toolkits for subretinal prosthetic devices.

Suggested Citation

  • Jing Tang & Nan Qin & Yan Chong & Yupu Diao & Yiliguma & Zhexuan Wang & Tian Xue & Min Jiang & Jiayi Zhang & Gengfeng Zheng, 2018. "Nanowire arrays restore vision in blind mice," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03212-0
    DOI: 10.1038/s41467-018-03212-0
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    Cited by:

    1. Paola Vagni & Marta Jole Ildelfonsa Airaghi Leccardi & Charles-Henri Vila & Elodie Geneviève Zollinger & Golnaz Sherafatipour & Thomas J. Wolfensberger & Diego Ghezzi, 2022. "POLYRETINA restores light responses in vivo in blind Göttingen minipigs," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Ting Jiang & Yiru Wang & Yingshuang Zheng & Le Wang & Xiang He & Liqiang Li & Yunfeng Deng & Huanli Dong & Hongkun Tian & Yanhou Geng & Linghai Xie & Yong Lei & Haifeng Ling & Deyang Ji & Wenping Hu, 2023. "Tetrachromatic vision-inspired neuromorphic sensors with ultraweak ultraviolet detection," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    3. Pengcheng Sun & Chaochao Li & Can Yang & Mengchun Sun & Hanqing Hou & Yanjun Guan & Jinger Chen & Shangbin Liu & Kuntao Chen & Yuan Ma & Yunxiang Huang & Xiangling Li & Huachun Wang & Liu Wang & Sheng, 2024. "A biodegradable and flexible neural interface for transdermal optoelectronic modulation and regeneration of peripheral nerves," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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