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Activatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer

Author

Listed:
  • Yuyan Jiang

    (Nanyang Technological University)

  • Jiaguo Huang

    (Nanyang Technological University)

  • Cheng Xu

    (Nanyang Technological University)

  • Kanyi Pu

    (Nanyang Technological University
    Nanyang Technological University)

Abstract

Nanomedicine in combination with immunotherapy offers opportunities to treat cancer in a safe and effective manner; however, remote control of immune response with spatiotemporal precision remains challenging. We herein report a photothermally activatable polymeric pro-nanoagonist (APNA) that is specifically regulated by deep-tissue-penetrating second near-infrared (NIR-II) light for combinational photothermal immunotherapy. APNA is constructed from covalent conjugation of an immunostimulant onto a NIR-II semiconducting transducer through a labile thermo-responsive linker. Upon NIR-II photoirradiation, APNA mediates photothermal effect, which not only triggers tumor ablation and immunogenic cell death but also initiates the cleavage of thermolabile linker to liberate caged agonist for in-situ immune activation in deep solid tumor (8 mm). Such controlled immune regulation potentiates systemic antitumor immunity, leading to promoted cytotoxic T lymphocytes and helper T cell infiltration in distal tumor, lung and liver to inhibit cancer metastasis. Thereby, the present work illustrates a generic strategy to prepare pro-immunostimulants for spatiotemporal regulation of cancer nano-immunotherapy.

Suggested Citation

  • Yuyan Jiang & Jiaguo Huang & Cheng Xu & Kanyi Pu, 2021. "Activatable polymer nanoagonist for second near-infrared photothermal immunotherapy of cancer," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21047-0
    DOI: 10.1038/s41467-021-21047-0
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    Cited by:

    1. Ke-Fei Xu & Shun-Yu Wu & Zihao Wang & Yuxin Guo & Ya-Xuan Zhu & Chengcheng Li & Bai-Hui Shan & Xinping Zhang & Xiaoyang Liu & Fu-Gen Wu, 2024. "Hyperbaric oxygen enhances tumor penetration and accumulation of engineered bacteria for synergistic photothermal immunotherapy," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    2. Shanzhi Lyu & Yonglin He & Xinglei Tao & Yuge Yao & Xiangyi Huang & Yingchao Ma & Zhimin Peng & Yanjun Ding & Yapei Wang, 2022. "Subcutaneous power supply by NIR-II light," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. Chi Zhang & Jingsheng Huang & Ziling Zeng & Shasha He & Penghui Cheng & Jingchao Li & Kanyi Pu, 2022. "Catalytical nano-immunocomplexes for remote-controlled sono-metabolic checkpoint trimodal cancer therapy," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Jingchao Li & Yu Luo & Ziling Zeng & Dong Cui & Jiaguo Huang & Chenjie Xu & Liping Li & Kanyi Pu & Ruiping Zhang, 2022. "Precision cancer sono-immunotherapy using deep-tissue activatable semiconducting polymer immunomodulatory nanoparticles," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    5. Xin Li & Tuying Yong & Zhaohan Wei & Nana Bie & Xiaoqiong Zhang & Guiting Zhan & Jianye Li & Jiaqi Qin & Jingjing Yu & Bixiang Zhang & Lu Gan & Xiangliang Yang, 2022. "Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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