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Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy

Author

Listed:
  • Liping Huang

    (Huazhong University of Science and Technology)

  • Yanan Li

    (China Pharmaceutical University)

  • Yunai Du

    (China Pharmaceutical University)

  • Yiyi Zhang

    (Huazhong University of Science and Technology)

  • Xiuxia Wang

    (Huazhong University of Science and Technology)

  • Yuan Ding

    (China Pharmaceutical University)

  • Xiangliang Yang

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Fanling Meng

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Jiasheng Tu

    (China Pharmaceutical University)

  • Liang Luo

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Chunmeng Sun

    (China Pharmaceutical University)

Abstract

One of the main challenges for immune checkpoint blockade antibodies lies in malignancies with limited T-cell responses or immunologically “cold” tumors. Inspired by the capability of fever-like heat in inducing an immune-favorable tumor microenvironment, mild photothermal therapy (PTT) is proposed to sensitize tumors to immune checkpoint inhibition and turn “cold” tumors “hot.” Here we present a combined all-in-one and all-in-control strategy to realize a local symbiotic mild photothermal-assisted immunotherapy (SMPAI). We load both a near-infrared (NIR) photothermal agent IR820 and a programmed death-ligand 1 antibody (aPD-L1) into a lipid gel depot with a favorable property of thermally reversible gel-to-sol phase transition. Manually controlled NIR irradiation regulates the release of aPD-L1 and, more importantly, increases the recruitment of tumor-infiltrating lymphocytes and boosts T-cell activity against tumors. In vivo antitumor studies on 4T1 and B16F10 models demonstrate that SMPAI is an effective and promising strategy for treating “cold” tumors.

Suggested Citation

  • Liping Huang & Yanan Li & Yunai Du & Yiyi Zhang & Xiuxia Wang & Yuan Ding & Xiangliang Yang & Fanling Meng & Jiasheng Tu & Liang Luo & Chunmeng Sun, 2019. "Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-12771-9
    DOI: 10.1038/s41467-019-12771-9
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    Cited by:

    1. Xuan Wang & Yingqi Liu & Chencheng Xue & Yan Hu & Yuanyuan Zhao & Kaiyong Cai & Menghuan Li & Zhong Luo, 2022. "A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    2. Yiyi Zhang & Sidan Tian & Liping Huang & Yanan Li & Yuan Lu & Hongyu Li & Guiping Chen & Fanling Meng & Gang L. Liu & Xiangliang Yang & Jiasheng Tu & Chunmeng Sun & Liang Luo, 2022. "Reactive oxygen species-responsive and Raman-traceable hydrogel combining photodynamic and immune therapy for postsurgical cancer treatment," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Jingchao Li & Yu Luo & Ziling Zeng & Dong Cui & Jiaguo Huang & Chenjie Xu & Liping Li & Kanyi Pu & Ruiping Zhang, 2022. "Precision cancer sono-immunotherapy using deep-tissue activatable semiconducting polymer immunomodulatory nanoparticles," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Jing Lin & Shihui Sun & Kui Zhao & Fei Gao & Renling Wang & Qi Li & Yanlong Zhou & Jing Zhang & Yue Li & Xinyue Wang & Le Du & Shuai Wang & Zi Li & Huijun Lu & Yungang Lan & Deguang Song & Wei Guo & Y, 2023. "Oncolytic Parapoxvirus induces Gasdermin E-mediated pyroptosis and activates antitumor immunity," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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