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Ultrasound-induced reorientation for multi-angle optical coherence tomography

Author

Listed:
  • Mia Kvåle Løvmo

    (Medical University of Innsbruck)

  • Shiyu Deng

    (Medical University of Vienna)

  • Simon Moser

    (Medical University of Innsbruck)

  • Rainer Leitgeb

    (Medical University of Vienna)

  • Wolfgang Drexler

    (Medical University of Vienna)

  • Monika Ritsch-Marte

    (Medical University of Innsbruck)

Abstract

Organoid and spheroid technology provide valuable insights into developmental biology and oncology. Optical coherence tomography (OCT) is a label-free technique that has emerged as an excellent tool for monitoring the structure and function of these samples. However, mature organoids are often too opaque for OCT. Access to multi-angle views is highly desirable to overcome this limitation, preferably with non-contact sample handling. To fulfil these requirements, we present an ultrasound-induced reorientation method for multi-angle-OCT, which employs a 3D-printed acoustic trap inserted into an OCT imaging system, to levitate and reorient zebrafish larvae and tumor spheroids in a controlled and reproducible manner. A model-based algorithm was developed for the physically consistent fusion of multi-angle data from a priori unknown angles. We demonstrate enhanced penetration depth in the joint 3D-recovery of reflectivity, attenuation, refractive index, and position registration for zebrafish larvae, creating an enabling tool for future applications in volumetric imaging.

Suggested Citation

  • Mia Kvåle Løvmo & Shiyu Deng & Simon Moser & Rainer Leitgeb & Wolfgang Drexler & Monika Ritsch-Marte, 2024. "Ultrasound-induced reorientation for multi-angle optical coherence tomography," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46506-2
    DOI: 10.1038/s41467-024-46506-2
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    References listed on IDEAS

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    1. Daniel Ahmed & Adem Ozcelik & Nagagireesh Bojanala & Nitesh Nama & Awani Upadhyay & Yuchao Chen & Wendy Hanna-Rose & Tony Jun Huang, 2016. "Rotational manipulation of single cells and organisms using acoustic waves," Nature Communications, Nature, vol. 7(1), pages 1-11, April.
    2. Asier Marzo & Sue Ann Seah & Bruce W. Drinkwater & Deepak Ranjan Sahoo & Benjamin Long & Sriram Subramanian, 2015. "Holographic acoustic elements for manipulation of levitated objects," Nature Communications, Nature, vol. 6(1), pages 1-7, December.
    3. Itia A. Favre-Bulle & Alexander B. Stilgoe & Halina Rubinsztein-Dunlop & Ethan K. Scott, 2017. "Optical trapping of otoliths drives vestibular behaviours in larval zebrafish," Nature Communications, Nature, vol. 8(1), pages 1-7, December.
    4. Zhengyi Yang & Katy L. H. Cole & Yongqiang Qiu & Ildikó M. L. Somorjai & Philip Wijesinghe & Jonathan Nylk & Sandy Cochran & Gabriel C. Spalding & David A. Lyons & Kishan Dholakia, 2019. "Light sheet microscopy with acoustic sample confinement," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
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