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Brain-wide visual habituation networks in wild type and fmr1 zebrafish

Author

Listed:
  • Emmanuel Marquez-Legorreta

    (The University of Queensland
    Howard Hughes Medical Institute)

  • Lena Constantin

    (The University of Queensland)

  • Marielle Piber

    (University of Aberdeen)

  • Itia A. Favre-Bulle

    (The University of Queensland
    The University of Queensland)

  • Michael A. Taylor

    (The University of Queensland)

  • Ann S. Blevins

    (University of Pennsylvania)

  • Jean Giacomotto

    (The University of Queensland
    West Moreton Hospital and Health Service
    Griffith University
    Griffith University)

  • Dani S. Bassett

    (University of Pennsylvania
    University of Pennsylvania
    Santa Fe Institute)

  • Gilles C. Vanwalleghem

    (The University of Queensland
    Department of Molecular Biology and Genetics, Aarhus University)

  • Ethan K. Scott

    (The University of Queensland)

Abstract

Habituation is a form of learning during which animals stop responding to repetitive stimuli, and deficits in habituation are characteristic of several psychiatric disorders. Due to technical challenges, the brain-wide networks mediating habituation are poorly understood. Here we report brain-wide calcium imaging during larval zebrafish habituation to repeated visual looming stimuli. We show that different functional categories of loom-sensitive neurons are located in characteristic locations throughout the brain, and that both the functional properties of their networks and the resulting behavior can be modulated by stimulus saliency and timing. Using graph theory, we identify a visual circuit that habituates minimally, a moderately habituating midbrain population proposed to mediate the sensorimotor transformation, and downstream circuit elements responsible for higher order representations and the delivery of behavior. Zebrafish larvae carrying a mutation in the fmr1 gene have a systematic shift toward sustained premotor activity in this network, and show slower behavioral habituation.

Suggested Citation

  • Emmanuel Marquez-Legorreta & Lena Constantin & Marielle Piber & Itia A. Favre-Bulle & Michael A. Taylor & Ann S. Blevins & Jean Giacomotto & Dani S. Bassett & Gilles C. Vanwalleghem & Ethan K. Scott, 2022. "Brain-wide visual habituation networks in wild type and fmr1 zebrafish," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28299-4
    DOI: 10.1038/s41467-022-28299-4
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    References listed on IDEAS

    as
    1. João C. Marques & Meng Li & Diane Schaak & Drew N. Robson & Jennifer M. Li, 2020. "Internal state dynamics shape brainwide activity and foraging behaviour," Nature, Nature, vol. 577(7789), pages 239-243, January.
    2. Itia A. Favre-Bulle & Alexander B. Stilgoe & Halina Rubinsztein-Dunlop & Ethan K. Scott, 2017. "Optical trapping of otoliths drives vestibular behaviours in larval zebrafish," Nature Communications, Nature, vol. 8(1), pages 1-7, December.
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    Cited by:

    1. Jesús Pérez-Ortega & Alejandro Akrouh & Rafael Yuste, 2024. "Stimulus encoding by specific inactivation of cortical neurons," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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