IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-35495-9.html
   My bibliography  Save this article

Lossless enrichment of trace analytes in levitating droplets for multiphase and multiplex detection

Author

Listed:
  • Xueyan Chen

    (Zhejiang University
    Zhejiang University School of Medicine)

  • Qianqian Ding

    (Zhejiang University)

  • Chao Bi

    (Zhejiang University School of Medicine)

  • Jian Ruan

    (Zhejiang University School of Medicine)

  • Shikuan Yang

    (Zhejiang University
    Zhejiang University School of Medicine
    Zhejiang University
    Baotou Research Institute of Rare Earths)

Abstract

Concentrating a trace amount of molecules from liquids, solid objects, or the gas phase and delivering them to a localized area are crucial for almost any trace analyte detection device. Analytes within a liquid droplet resting on micro/nanostructured surfaces with liquid-repellent coatings can be concentrated during solvent evaporation. However, these coatings suffer from complex manufacturing procedures, poor versatility, and limited analyte enrichment efficiency. Here, we report on the use of an acoustic levitation platform to losslessly concentrate the analyte molecules dissolved in any volatile liquid, attached to solid objects, or spread in air. Gold nanoparticles can be simultaneously concentrated with the analytes in different phases, realizing sensitive, surface-enhanced Raman scattering detection even at attomolar (10−18 mol/L) concentration levels. The acoustic levitation platform-enabled, lossless analyte enrichment can significantly increase the analytical performance of many conventional microsensing techniques.

Suggested Citation

  • Xueyan Chen & Qianqian Ding & Chao Bi & Jian Ruan & Shikuan Yang, 2022. "Lossless enrichment of trace analytes in levitating droplets for multiphase and multiplex detection," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35495-9
    DOI: 10.1038/s41467-022-35495-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-35495-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-35495-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Asier Marzo & Sue Ann Seah & Bruce W. Drinkwater & Deepak Ranjan Sahoo & Benjamin Long & Sriram Subramanian, 2015. "Holographic acoustic elements for manipulation of levitated objects," Nature Communications, Nature, vol. 6(1), pages 1-7, December.
    2. Partha Pratim Patra & Rohit Chikkaraddy & Ravi P. N. Tripathi & Arindam Dasgupta & G. V. Pavan Kumar, 2014. "Plasmofluidic single-molecule surface-enhanced Raman scattering from dynamic assembly of plasmonic nanoparticles," Nature Communications, Nature, vol. 5(1), pages 1-8, September.
    3. Lingling Zhang & Yu Guo & Rui Hao & Yafei Shi & Hongjun You & Hu Nan & Yanzhu Dai & Danjun Liu & Dangyuan Lei & Jixiang Fang, 2021. "Ultra-rapid and highly efficient enrichment of organic pollutants via magnetic mesoporous nanosponge for ultrasensitive nanosensors," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    4. Jian Feng Li & Yi Fan Huang & Yong Ding & Zhi Lin Yang & Song Bo Li & Xiao Shun Zhou & Feng Ru Fan & Wei Zhang & Zhi You Zhou & De Yin Wu & Bin Ren & Zhong Lin Wang & Zhong Qun Tian, 2010. "Shell-isolated nanoparticle-enhanced Raman spectroscopy," Nature, Nature, vol. 464(7287), pages 392-395, March.
    5. Alfredo Quijano-Rubio & Hsien-Wei Yeh & Jooyoung Park & Hansol Lee & Robert A. Langan & Scott E. Boyken & Marc J. Lajoie & Longxing Cao & Cameron M. Chow & Marcos C. Miranda & Jimin Wi & Hyo Jeong Hon, 2021. "De novo design of modular and tunable protein biosensors," Nature, Nature, vol. 591(7850), pages 482-487, March.
    6. E. H. Brandt, 2001. "Suspended by sound," Nature, Nature, vol. 413(6855), pages 474-475, October.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Youyou Lu & Xuan Zhang & Liyan Zhao & Hong Liu & Mi Yan & Xiaochen Zhang & Kenji Mochizuki & Shikuan Yang, 2023. "Metal-organic framework template-guided electrochemical lithography on substrates for SERS sensing applications," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Matthew Stein & Sam Keller & Yujie Luo & Ognjen Ilic, 2022. "Shaping contactless radiation forces through anomalous acoustic scattering," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    2. Zhi Chang & Huijun Yang & Xingyu Zhu & Ping He & Haoshen Zhou, 2022. "A stable quasi-solid electrolyte improves the safe operation of highly efficient lithium-metal pouch cells in harsh environments," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Zhi Chang & Huijun Yang & Anqiang Pan & Ping He & Haoshen Zhou, 2022. "An improved 9 micron thick separator for a 350 Wh/kg lithium metal rechargeable pouch cell," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Xiao-Ting Yin & En-Ming You & Ru-Yu Zhou & Li-Hong Zhu & Wei-Wei Wang & Kai-Xuan Li & De-Yin Wu & Yu Gu & Jian-Feng Li & Bing-Wei Mao & Jia-Wei Yan, 2024. "Unraveling the energy storage mechanism in graphene-based nonaqueous electrochemical capacitors by gap-enhanced Raman spectroscopy," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    5. Yasmine S. Zubi & Kosuke Seki & Ying Li & Andrew C. Hunt & Bingqing Liu & Benoît Roux & Michael C. Jewett & Jared C. Lewis, 2022. "Metal-responsive regulation of enzyme catalysis using genetically encoded chemical switches," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    6. Chao-Yu Li & Ming Chen & Shuai Liu & Xinyao Lu & Jinhui Meng & Jiawei Yan & Héctor D. Abruña & Guang Feng & Tianquan Lian, 2022. "Unconventional interfacial water structure of highly concentrated aqueous electrolytes at negative electrode polarizations," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    7. Mia Kvåle Løvmo & Shiyu Deng & Simon Moser & Rainer Leitgeb & Wolfgang Drexler & Monika Ritsch-Marte, 2024. "Ultrasound-induced reorientation for multi-angle optical coherence tomography," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    8. Xiaoxia Chang & Sudarshan Vijay & Yaran Zhao & Nicholas J. Oliveira & Karen Chan & Bingjun Xu, 2022. "Understanding the complementarities of surface-enhanced infrared and Raman spectroscopies in CO adsorption and electrochemical reduction," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    9. William M. Dawson & Kathryn L. Shelley & Jordan M. Fletcher & D. Arne Scott & Lucia Lombardi & Guto G. Rhys & Tania J. LaGambina & Ulrike Obst & Antony J. Burton & Jessica A. Cross & George Davies & F, 2023. "Differential sensing with arrays of de novo designed peptide assemblies," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    10. Robert E. Jefferson & Aurélien Oggier & Andreas Füglistaler & Nicolas Camviel & Mahdi Hijazi & Ana Rico Villarreal & Caroline Arber & Patrick Barth, 2023. "Computational design of dynamic receptor—peptide signaling complexes applied to chemotaxis," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    11. Mahdi Derayatifar & Mohsen Habibi & Rama Bhat & Muthukumaran Packirisamy, 2024. "Holographic direct sound printing," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    12. Renming Liu & Ming Geng & Jindong Ai & Xinyi Fan & Zhixiang Liu & Yu-Wei Lu & Yanmin Kuang & Jing-Feng Liu & Lijun Guo & Lin Wu, 2024. "Deterministic positioning and alignment of a single-molecule exciton in plasmonic nanodimer for strong coupling," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    13. Lu Zhang & Wencai Yi & Junfang Li & Guoying Wei & Guangcheng Xi & Lanqun Mao, 2023. "Surfactant-free interfacial growth of graphdiyne hollow microspheres and the mechanistic origin of their SERS activity," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    14. Fu Wan & Lingling Du & Weigen Chen & Pinyi Wang & Jianxin Wang & Haiyang Shi, 2017. "A Novel Method to Directly Analyze Dissolved Acetic Acid in Transformer Oil without Extraction Using Raman Spectroscopy," Energies, MDPI, vol. 10(7), pages 1-12, July.
    15. Zhiyuan Zhang & Alexander Sukhov & Jens Harting & Paolo Malgaretti & Daniel Ahmed, 2022. "Rolling microswarms along acoustic virtual walls," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    16. Lingling Zhang & Yu Guo & Rui Hao & Yafei Shi & Hongjun You & Hu Nan & Yanzhu Dai & Danjun Liu & Dangyuan Lei & Jixiang Fang, 2021. "Ultra-rapid and highly efficient enrichment of organic pollutants via magnetic mesoporous nanosponge for ultrasensitive nanosensors," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    17. Qian Lv & Junyang Tan & Zhijie Wang & Peng Gu & Haiyun Liu & Lingxiao Yu & Yinping Wei & Lin Gan & Bilu Liu & Jia Li & Feiyu Kang & Hui-Ming Cheng & Qihua Xiong & Ruitao Lv, 2023. "Ultrafast charge transfer in mixed-dimensional WO3-x nanowire/WSe2 heterostructures for attomolar-level molecular sensing," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    18. Zhong Guo & Rinky D. Parakra & Ying Xiong & Wayne A. Johnston & Patricia Walden & Selvakumar Edwardraja & Shayli Varasteh Moradi & Jacobus P. J. Ungerer & Hui-wang Ai & Jonathan J. Phillips & Kirill A, 2022. "Engineering and exploiting synthetic allostery of NanoLuc luciferase," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    19. Ruoqin Zhang & Xichuan Zhao & Jinzhi Li & Di Zhou & Honglian Guo & Zhi-yuan Li & Feng Li, 2024. "Programmable photoacoustic patterning of microparticles in air," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    20. Ye Yang & Yaozhang Yang & Dingyuan Liu & Yuanyuan Wang & Minqiao Lu & Qi Zhang & Jiqing Huang & Yongchuan Li & Teng Ma & Fei Yan & Hairong Zheng, 2023. "In-vivo programmable acoustic manipulation of genetically engineered bacteria," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35495-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.