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Organization of the gravity-sensing system in zebrafish

Author

Listed:
  • Zhikai Liu

    (Washington University in St. Louis)

  • David G. C. Hildebrand

    (The Rockefeller University)

  • Joshua L. Morgan

    (Washington University in St. Louis)

  • Yizhen Jia

    (Washington University in St. Louis)

  • Nicholas Slimmon

    (Washington University in St. Louis)

  • Martha W. Bagnall

    (Washington University in St. Louis)

Abstract

Motor circuits develop in sequence from those governing fast movements to those governing slow. Here we examine whether upstream sensory circuits are organized by similar principles. Using serial-section electron microscopy in larval zebrafish, we generated a complete map of the gravity-sensing (utricular) system spanning from the inner ear to the brainstem. We find that both sensory tuning and developmental sequence are organizing principles of vestibular topography. Patterned rostrocaudal innervation from hair cells to afferents creates an anatomically inferred directional tuning map in the utricular ganglion, forming segregated pathways for rostral and caudal tilt. Furthermore, the mediolateral axis of the ganglion is linked to both developmental sequence and neuronal temporal dynamics. Early-born pathways carrying phasic information preferentially excite fast escape circuits, whereas later-born pathways carrying tonic signals excite slower postural and oculomotor circuits. These results demonstrate that vestibular circuits are organized by tuning direction and dynamics, aligning them with downstream motor circuits and behaviors.

Suggested Citation

  • Zhikai Liu & David G. C. Hildebrand & Joshua L. Morgan & Yizhen Jia & Nicholas Slimmon & Martha W. Bagnall, 2022. "Organization of the gravity-sensing system in zebrafish," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32824-w
    DOI: 10.1038/s41467-022-32824-w
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    References listed on IDEAS

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    1. David L. McLean & Jingyi Fan & Shin-ichi Higashijima & Melina E. Hale & Joseph R. Fetcho, 2007. "A topographic map of recruitment in spinal cord," Nature, Nature, vol. 446(7131), pages 71-75, March.
    2. Mohsen Jamali & Maurice J. Chacron & Kathleen E. Cullen, 2016. "Self-motion evokes precise spike timing in the primate vestibular system," Nature Communications, Nature, vol. 7(1), pages 1-14, December.
    3. Itia A. Favre-Bulle & Alexander B. Stilgoe & Halina Rubinsztein-Dunlop & Ethan K. Scott, 2017. "Optical trapping of otoliths drives vestibular behaviours in larval zebrafish," Nature Communications, Nature, vol. 8(1), pages 1-7, December.
    4. Kazuya Ono & James Keller & Omar López Ramírez & Antonia González Garrido & Omid A. Zobeiri & Hui Ho Vanessa Chang & Sarath Vijayakumar & Andrianna Ayiotis & Gregg Duester & Charles C. Della Santina &, 2020. "Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
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