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Biomechanics and neural circuits for vestibular-induced fine postural control in larval zebrafish

Author

Listed:
  • Takumi Sugioka

    (Exploratory Research Center on Life and Living Systems
    National Institute for Basic Biology
    The Graduate University for Advanced Studies, SOKENDAI)

  • Masashi Tanimoto

    (Exploratory Research Center on Life and Living Systems
    National Institute for Basic Biology
    The Graduate University for Advanced Studies, SOKENDAI)

  • Shin-ichi Higashijima

    (Exploratory Research Center on Life and Living Systems
    National Institute for Basic Biology
    The Graduate University for Advanced Studies, SOKENDAI)

Abstract

Land-walking vertebrates maintain a desirable posture by finely controlling muscles. It is unclear whether fish also finely control posture in the water. Here, we showed that larval zebrafish have fine posture control. When roll-tilted, fish recovered their upright posture using a reflex behavior, which was a slight body bend near the swim bladder. The vestibular-induced body bend produces a misalignment between gravity and buoyancy, generating a moment of force that recovers the upright posture. We identified the neural circuits for the reflex, including the vestibular nucleus (tangential nucleus) through reticulospinal neurons (neurons in the nucleus of the medial longitudinal fasciculus) to the spinal cord, and finally to the posterior hypaxial muscles, a special class of muscles near the swim bladder. These results suggest that fish maintain a dorsal-up posture by frequently performing the body bend reflex and demonstrate that the reticulospinal pathway plays a critical role in fine postural control.

Suggested Citation

  • Takumi Sugioka & Masashi Tanimoto & Shin-ichi Higashijima, 2023. "Biomechanics and neural circuits for vestibular-induced fine postural control in larval zebrafish," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36682-y
    DOI: 10.1038/s41467-023-36682-y
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    References listed on IDEAS

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    1. Itia A. Favre-Bulle & Alexander B. Stilgoe & Halina Rubinsztein-Dunlop & Ethan K. Scott, 2017. "Optical trapping of otoliths drives vestibular behaviours in larval zebrafish," Nature Communications, Nature, vol. 8(1), pages 1-7, December.
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