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Fully bioresorbable hybrid opto-electronic neural implant system for simultaneous electrophysiological recording and optogenetic stimulation

Author

Listed:
  • Myeongki Cho

    (Yonsei University)

  • Jeong-Kyu Han

    (Korea Institute of Science and Technology)

  • Jungmin Suh

    (Yonsei University)

  • Jeong Jin Kim

    (Pusan National University)

  • Jae Ryun Ryu

    (Korea University)

  • In Sik Min

    (Yonsei University)

  • Mingyu Sang

    (Yonsei University)

  • Selin Lim

    (Yonsei University)

  • Tae Soo Kim

    (Yonsei University)

  • Kyubeen Kim

    (Yonsei University)

  • Kyowon Kang

    (Yonsei University)

  • Kyuhyun Hwang

    (Yonsei University)

  • Kanghwan Kim

    (Korea Institute of Science and Technology)

  • Eun-Bin Hong

    (Korea Institute of Science and Technology 5)

  • Min-Ho Nam

    (Korea Institute of Science and Technology 5)

  • Jongbaeg Kim

    (Yonsei University)

  • Young Min Song

    (Gwangju Institute of Science and Technology (GIST))

  • Gil Ju Lee

    (Pusan National University)

  • Il-Joo Cho

    (Korea University
    Korea University)

  • Ki Jun Yu

    (Yonsei University
    Yonsei University)

Abstract

Bioresorbable neural implants based on emerging classes of biodegradable materials offer a promising solution to the challenges of secondary surgeries for removal of implanted devices required for existing neural implants. In this study, we introduce a fully bioresorbable flexible hybrid opto-electronic system for simultaneous electrophysiological recording and optogenetic stimulation. The flexible and soft device, composed of biodegradable materials, has a direct optical and electrical interface with the curved cerebral cortex surface while exhibiting excellent biocompatibility. Optimized to minimize light transmission losses and photoelectric artifact interference, the device was chronically implanted in the brain of transgenic mice and performed to photo-stimulate the somatosensory area while recording local field potentials. Thus, the presented hybrid neural implant system, comprising biodegradable materials, promises to provide monitoring and therapy modalities for versatile applications in biomedicine.

Suggested Citation

  • Myeongki Cho & Jeong-Kyu Han & Jungmin Suh & Jeong Jin Kim & Jae Ryun Ryu & In Sik Min & Mingyu Sang & Selin Lim & Tae Soo Kim & Kyubeen Kim & Kyowon Kang & Kyuhyun Hwang & Kanghwan Kim & Eun-Bin Hong, 2024. "Fully bioresorbable hybrid opto-electronic neural implant system for simultaneous electrophysiological recording and optogenetic stimulation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45803-0
    DOI: 10.1038/s41467-024-45803-0
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    References listed on IDEAS

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    1. Seung-Kyun Kang & Rory K. J. Murphy & Suk-Won Hwang & Seung Min Lee & Daniel V. Harburg & Neil A. Krueger & Jiho Shin & Paul Gamble & Huanyu Cheng & Sooyoun Yu & Zhuangjian Liu & Jordan G. McCall & Ma, 2016. "Bioresorbable silicon electronic sensors for the brain," Nature, Nature, vol. 530(7588), pages 71-76, February.
    2. Seongjun Park & Hyunwoo Yuk & Ruike Zhao & Yeong Shin Yim & Eyob W. Woldeghebriel & Jeewoo Kang & Andres Canales & Yoel Fink & Gloria B. Choi & Xuanhe Zhao & Polina Anikeeva, 2021. "Adaptive and multifunctional hydrogel hybrid probes for long-term sensing and modulation of neural activity," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    3. Hyogeun Shin & Sohyeon Jeong & Ju-Hyun Lee & Woong Sun & Nakwon Choi & Il-Joo Cho, 2021. "3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    4. Sedat Nizamoglu & Malte C. Gather & Matjaž Humar & Myunghwan Choi & Seonghoon Kim & Ki Su Kim & Sei Kwang Hahn & Giuliano Scarcelli & Mark Randolph & Robert W. Redmond & Seok Hyun Yun, 2016. "Bioabsorbable polymer optical waveguides for deep-tissue photomedicine," Nature Communications, Nature, vol. 7(1), pages 1-7, April.
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