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3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics

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  • Hyogeun Shin

    (Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST)
    Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology (UST))

  • Sohyeon Jeong

    (Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST)
    Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology (UST))

  • Ju-Hyun Lee

    (Korea University College of Medicine)

  • Woong Sun

    (Korea University College of Medicine)

  • Nakwon Choi

    (Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST)
    Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology (UST)
    KU-KIST Graduate School of Converging Science and Technology)

  • Il-Joo Cho

    (Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST)
    Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology (UST)
    School of Electrical and Electronics Engineering, Yonsei University
    Yonsei-KIST Convergence Research Institute, Yonsei University)

Abstract

Investigation of neural circuit dynamics is crucial for deciphering the functional connections among regions of the brain and understanding the mechanism of brain dysfunction. Despite the advancements of neural circuit models in vitro, technologies for both precisely monitoring and modulating neural activities within three-dimensional (3D) neural circuit models have yet to be developed. Specifically, no existing 3D microelectrode arrays (MEAs) have integrated capabilities to stimulate surrounding neurons and to monitor the temporal evolution of the formation of a neural network in real time. Herein, we present a 3D high-density multifunctional MEA with optical stimulation and drug delivery for investigating neural circuit dynamics within engineered 3D neural tissues. We demonstrate precise measurements of synaptic latencies in 3D neural networks. We expect our 3D multifunctional MEA to open up opportunities for studies of neural circuits through precise, in vitro investigations of neural circuit dynamics with 3D brain models.

Suggested Citation

  • Hyogeun Shin & Sohyeon Jeong & Ju-Hyun Lee & Woong Sun & Nakwon Choi & Il-Joo Cho, 2021. "3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-020-20763-3
    DOI: 10.1038/s41467-020-20763-3
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    Cited by:

    1. Myeongki Cho & Jeong-Kyu Han & Jungmin Suh & Jeong Jin Kim & Jae Ryun Ryu & In Sik Min & Mingyu Sang & Selin Lim & Tae Soo Kim & Kyubeen Kim & Kyowon Kang & Kyuhyun Hwang & Kanghwan Kim & Eun-Bin Hong, 2024. "Fully bioresorbable hybrid opto-electronic neural implant system for simultaneous electrophysiological recording and optogenetic stimulation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Yihang Wang & Zeka Chen & Brayden Davis & Will Lipman & Sicheng Xing & Lin Zhang & Tian Wang & Priyash Hafiz & Wanrong Xie & Zijie Yan & Zhili Huang & Juan Song & Wubin Bai, 2024. "Digital automation of transdermal drug delivery with high spatiotemporal resolution," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Tal Sharf & Tjitse Molen & Stella M. K. Glasauer & Elmer Guzman & Alessio P. Buccino & Gabriel Luna & Zhuowei Cheng & Morgane Audouard & Kamalini G. Ranasinghe & Kiwamu Kudo & Srikantan S. Nagarajan &, 2022. "Functional neuronal circuitry and oscillatory dynamics in human brain organoids," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    4. Yousang Yoon & Hyogeun Shin & Donghak Byun & Jiwan Woo & Yakdol Cho & Nakwon Choi & Il-Joo Cho, 2022. "Neural probe system for behavioral neuropharmacology by bi-directional wireless drug delivery and electrophysiology in socially interacting mice," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    5. Jung Min Lee & Young-Woo Pyo & Yeon Jun Kim & Jin Hee Hong & Yonghyeon Jo & Wonshik Choi & Dingchang Lin & Hong-Gyu Park, 2023. "The ultra-thin, minimally invasive surface electrode array NeuroWeb for probing neural activity," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    6. Young-Geun Park & Yong Won Kwon & Chin Su Koh & Enji Kim & Dong Ha Lee & Sumin Kim & Jongmin Mun & Yeon-Mi Hong & Sanghoon Lee & Ju-Young Kim & Jae-Hyun Lee & Hyun Ho Jung & Jinwoo Cheon & Jin Woo Cha, 2024. "In-vivo integration of soft neural probes through high-resolution printing of liquid electronics on the cranium," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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