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Neural probe system for behavioral neuropharmacology by bi-directional wireless drug delivery and electrophysiology in socially interacting mice

Author

Listed:
  • Yousang Yoon

    (Korea Institute of Science and Technology (KIST))

  • Hyogeun Shin

    (Korea Institute of Science and Technology (KIST))

  • Donghak Byun

    (Korea Institute of Science and Technology (KIST))

  • Jiwan Woo

    (Korea Institute of Science and Technology (KIST))

  • Yakdol Cho

    (Korea Institute of Science and Technology (KIST))

  • Nakwon Choi

    (Korea Institute of Science and Technology (KIST)
    Korea University)

  • Il-Joo Cho

    (Korea University)

Abstract

Assessing the neurological and behavioral effects of drugs is important in developing pharmacological treatments, as well as understanding the mechanisms associated with neurological disorders. Herein, we present a miniaturized, wireless neural probe system with the capability of delivering drugs for the real-time investigation of the effects of the drugs on both behavioral and neural activities in socially interacting mice. We demonstrate wireless drug delivery and simultaneous monitoring of the resulting neural, behavioral changes, as well as the dose-dependent and repeatable responses to drugs. Furthermore, in pairs of mice, we use a food competition assay in which social interaction was modulated by the delivery of the drug, and the resulting changes in their neural activities are analyzed. During modulated food competition by drug injection, we observe changes in neural activity in mPFC region of a participating mouse over time. Our system may provide new opportunities for the development of studying the effects of drugs on behaviour and neural activity.

Suggested Citation

  • Yousang Yoon & Hyogeun Shin & Donghak Byun & Jiwan Woo & Yakdol Cho & Nakwon Choi & Il-Joo Cho, 2022. "Neural probe system for behavioral neuropharmacology by bi-directional wireless drug delivery and electrophysiology in socially interacting mice," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33296-8
    DOI: 10.1038/s41467-022-33296-8
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    References listed on IDEAS

    as
    1. Peter M. Eimon & Mostafa Ghannad-Rezaie & Gianluca De Rienzo & Amin Allalou & Yuelong Wu & Mu Gao & Ambrish Roy & Jeffrey Skolnick & Mehmet Fatih Yanik, 2018. "Brain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    2. Hyogeun Shin & Sohyeon Jeong & Ju-Hyun Lee & Woong Sun & Nakwon Choi & Il-Joo Cho, 2021. "3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    3. Hyogeun Shin & Yoojin Son & Uikyu Chae & Jeongyeon Kim & Nakwon Choi & Hyunjoo J. Lee & Jiwan Woo & Yakdol Cho & Soo Hyun Yang & C. Justin Lee & Il-Joo Cho, 2019. "Multifunctional multi-shank neural probe for investigating and modulating long-range neural circuits in vivo," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
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    Cited by:

    1. Sizhe Huang & Xinyue Liu & Shaoting Lin & Christopher Glynn & Kayla Felix & Atharva Sahasrabudhe & Collin Maley & Jingyi Xu & Weixuan Chen & Eunji Hong & Alfred J. Crosby & Qianbin Wang & Siyuan Rao, 2024. "Control of polymers’ amorphous-crystalline transition enables miniaturization and multifunctional integration for hydrogel bioelectronics," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Jongwoon Kim & Hengji Huang & Earl T. Gilbert & Kaiser C. Arndt & Daniel Fine English & Xiaoting Jia, 2024. "T-DOpE probes reveal sensitivity of hippocampal oscillations to cannabinoids in behaving mice," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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