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Digital automation of transdermal drug delivery with high spatiotemporal resolution

Author

Listed:
  • Yihang Wang

    (University of North Carolina at Chapel Hill)

  • Zeka Chen

    (University of North Carolina at Chapel Hill)

  • Brayden Davis

    (UNC/NCSU Joint Department of Biomedical Engineering)

  • Will Lipman

    (University of North Carolina at chapel Hill)

  • Sicheng Xing

    (UNC/NCSU Joint Department of Biomedical Engineering)

  • Lin Zhang

    (University of North Carolina at Chapel Hill)

  • Tian Wang

    (UNC/NCSU Joint Department of Biomedical Engineering)

  • Priyash Hafiz

    (UNC/NCSU Joint Department of Biomedical Engineering)

  • Wanrong Xie

    (University of North Carolina at Chapel Hill)

  • Zijie Yan

    (University of North Carolina at Chapel Hill)

  • Zhili Huang

    (Fudan University)

  • Juan Song

    (University of North Carolina at Chapel Hill)

  • Wubin Bai

    (University of North Carolina at Chapel Hill)

Abstract

Transdermal drug delivery is of vital importance for medical treatments. However, user adherence to long-term repetitive drug delivery poses a grand challenge. Furthermore, the dynamic and unpredictable disease progression demands a pharmaceutical treatment that can be actively controlled in real-time to ensure medical precision and personalization. Here, we report a spatiotemporal on-demand patch (SOP) that integrates drug-loaded microneedles with biocompatible metallic membranes to enable electrically triggered active control of drug release. Precise control of drug release to targeted locations (

Suggested Citation

  • Yihang Wang & Zeka Chen & Brayden Davis & Will Lipman & Sicheng Xing & Lin Zhang & Tian Wang & Priyash Hafiz & Wanrong Xie & Zijie Yan & Zhili Huang & Juan Song & Wubin Bai, 2024. "Digital automation of transdermal drug delivery with high spatiotemporal resolution," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44532-0
    DOI: 10.1038/s41467-023-44532-0
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    References listed on IDEAS

    as
    1. Hyogeun Shin & Sohyeon Jeong & Ju-Hyun Lee & Woong Sun & Nakwon Choi & Il-Joo Cho, 2021. "3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    2. Wei Chen & Rui Tian & Can Xu & Bryant C. Yung & Guohao Wang & Yijing Liu & Qianqian Ni & Fuwu Zhang & Zijian Zhou & Jingjing Wang & Gang Niu & Ying Ma & Liwu Fu & Xiaoyuan Chen, 2017. "Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy," Nature Communications, Nature, vol. 8(1), pages 1-11, December.
    3. John T. Santini & Michael J. Cima & Robert Langer, 1999. "A controlled-release microchip," Nature, Nature, vol. 397(6717), pages 335-338, January.
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