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Theta mediated dynamics of human hippocampal-neocortical learning systems in memory formation and retrieval

Author

Listed:
  • Sandra Gattas

    (University of California
    University of California)

  • Myra Sarai Larson

    (University of California
    University of California)

  • Lilit Mnatsakanyan

    (University of California)

  • Indranil Sen-Gupta

    (University of California)

  • Sumeet Vadera

    (University of California)

  • A. Lee Swindlehurst

    (University of California)

  • Paul E. Rapp

    (Uniformed Services University)

  • Jack J. Lin

    (University of California
    University of California)

  • Michael A. Yassa

    (University of California
    University of California
    University of California)

Abstract

Episodic memory arises as a function of dynamic interactions between the hippocampus and the neocortex, yet the mechanisms have remained elusive. Here, using human intracranial recordings during a mnemonic discrimination task, we report that 4-5 Hz (theta) power is differentially recruited during discrimination vs. overgeneralization, and its phase supports hippocampal-neocortical when memories are being formed and correctly retrieved. Interactions were largely bidirectional, with small but significant net directional biases; a hippocampus-to-neocortex bias during acquisition of new information that was subsequently correctly discriminated, and a neocortex-to-hippocampus bias during accurate discrimination of new stimuli from similar previously learned stimuli. The 4-5 Hz rhythm may facilitate the initial stages of information acquisition by neocortex during learning and the recall of stored information from cortex during retrieval. Future work should further probe these dynamics across different types of tasks and stimuli and computational models may need to be expanded accordingly to accommodate these findings.

Suggested Citation

  • Sandra Gattas & Myra Sarai Larson & Lilit Mnatsakanyan & Indranil Sen-Gupta & Sumeet Vadera & A. Lee Swindlehurst & Paul E. Rapp & Jack J. Lin & Michael A. Yassa, 2023. "Theta mediated dynamics of human hippocampal-neocortical learning systems in memory formation and retrieval," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-44011-6
    DOI: 10.1038/s41467-023-44011-6
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    References listed on IDEAS

    as
    1. D. Pacheco Estefan & M. Sánchez-Fibla & A. Duff & A. Principe & R. Rocamora & H. Zhang & N. Axmacher & P. F. M. J. Verschure, 2019. "Coordinated representational reinstatement in the human hippocampus and lateral temporal cortex during episodic memory retrieval," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    2. Torkel Hafting & Marianne Fyhn & Tora Bonnevie & May-Britt Moser & Edvard I. Moser, 2008. "Hippocampus-independent phase precession in entorhinal grid cells," Nature, Nature, vol. 453(7199), pages 1248-1252, June.
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