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Sleep fMRI with simultaneous electrophysiology at 9.4 T in male mice

Author

Listed:
  • Yalin Yu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yue Qiu

    (Fudan University)

  • Gen Li

    (Peking University)

  • Kaiwei Zhang

    (Chinese Academy of Sciences)

  • Binshi Bo

    (Chinese Academy of Sciences)

  • Mengchao Pei

    (Chinese Academy of Sciences)

  • Jingjing Ye

    (ShanghaiTech University)

  • Garth J. Thompson

    (ShanghaiTech University)

  • Jing Cang

    (Fudan University)

  • Fang Fang

    (Fudan University
    The Central Hospital of Xuhui District)

  • Yanqiu Feng

    (Southern Medical University)

  • Xiaojie Duan

    (Peking University)

  • Chuanjun Tong

    (Chinese Academy of Sciences
    Southern Medical University)

  • Zhifeng Liang

    (Chinese Academy of Sciences
    Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology)

Abstract

Sleep is ubiquitous and essential, but its mechanisms remain unclear. Studies in animals and humans have provided insights of sleep at vastly different spatiotemporal scales. However, challenges remain to integrate local and global information of sleep. Therefore, we developed sleep fMRI based on simultaneous electrophysiology at 9.4 T in male mice. Optimized un-anesthetized mouse fMRI setup allowed manifestation of NREM and REM sleep, and a large sleep fMRI dataset was collected and openly accessible. State dependent global patterns were revealed, and state transitions were found to be global, asymmetrical and sequential, which can be predicted up to 17.8 s using LSTM models. Importantly, sleep fMRI with hippocampal recording revealed potentiated sharp-wave ripple triggered global patterns during NREM than awake state, potentially attributable to co-occurrence of spindle events. To conclude, we established mouse sleep fMRI with simultaneous electrophysiology, and demonstrated its capability by revealing global dynamics of state transitions and neural events.

Suggested Citation

  • Yalin Yu & Yue Qiu & Gen Li & Kaiwei Zhang & Binshi Bo & Mengchao Pei & Jingjing Ye & Garth J. Thompson & Jing Cang & Fang Fang & Yanqiu Feng & Xiaojie Duan & Chuanjun Tong & Zhifeng Liang, 2023. "Sleep fMRI with simultaneous electrophysiology at 9.4 T in male mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37352-9
    DOI: 10.1038/s41467-023-37352-9
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    References listed on IDEAS

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    1. Gianina Ungurean & Mehdi Behroozi & Leonard Böger & Xavier Helluy & Paul-Antoine Libourel & Onur Güntürkün & Niels C. Rattenborg, 2023. "Wide-spread brain activation and reduced CSF flow during avian REM sleep," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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