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Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a

Author

Listed:
  • Yonggan Sun

    (Nanchang University
    Nanchang University
    Nanchang University)

  • Qixing Nie

    (Nanchang University
    Nanchang University
    Nanchang University)

  • Shanshan Zhang

    (Nanchang University
    Nanchang University
    Nanchang University)

  • Huijun He

    (Nanchang University
    Nanchang University
    Nanchang University)

  • Sheng Zuo

    (Nanchang University
    Nanchang University
    Nanchang University)

  • Chunhua Chen

    (Nanchang University
    Nanchang University
    Nanchang University)

  • Jingrui Yang

    (Nanchang University
    Nanchang University
    Nanchang University)

  • Haihong Chen

    (Nanchang University
    Nanchang University
    Nanchang University)

  • Jielun Hu

    (Nanchang University
    Nanchang University
    Nanchang University)

  • Song Li

    (Nanchang University
    Nanchang University
    Nanchang University)

  • Jiaobo Cheng

    (Nanchang University)

  • Baojie Zhang

    (Nanchang University)

  • Zhitian Zheng

    (Nanchang University)

  • Shijie Pan

    (Nanchang University)

  • Ping Huang

    (the First Affiliated Hospital of Nanchang University)

  • Lu Lian

    (the First Affiliated Hospital of Nanchang University)

  • Shaoping Nie

    (Nanchang University
    Nanchang University
    Nanchang University)

Abstract

Gut microbiota plays a key role in insulin resistance (IR). Here we perform a case-control study of Chinese adults (ChiCTR2200065715) and identify that Parabacteroides distasonis is inversely correlated with IR. Treatment with P. distasonis improves IR, strengthens intestinal integrity, and reduces systemic inflammation in mice. We further demonstrate that P. distasonis-derived nicotinic acid (NA) is a vital bioactive molecule that fortifies intestinal barrier function via activating intestinal G-protein-coupled receptor 109a (GPR109a), leading to ameliorating IR. We also conduct a bioactive dietary fiber screening to induce P. distasonis growth. Dendrobium officinale polysaccharide (DOP) shows favorable growth-promoting effects on P. distasonis and protects against IR in mice simultaneously. Finally, the reduced P. distasonis and NA levels were also validated in another human type 2 diabetes mellitus cohort. These findings reveal the unique mechanisms of P. distasonis on IR and provide viable strategies for the treatment and prevention of IR by bioactive dietary fiber.

Suggested Citation

  • Yonggan Sun & Qixing Nie & Shanshan Zhang & Huijun He & Sheng Zuo & Chunhua Chen & Jingrui Yang & Haihong Chen & Jielun Hu & Song Li & Jiaobo Cheng & Baojie Zhang & Zhitian Zheng & Shijie Pan & Ping H, 2023. "Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43622-3
    DOI: 10.1038/s41467-023-43622-3
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    1. Helle Krogh Pedersen & Valborg Gudmundsdottir & Henrik Bjørn Nielsen & Tuulia Hyotylainen & Trine Nielsen & Benjamin A. H. Jensen & Kristoffer Forslund & Falk Hildebrand & Edi Prifti & Gwen Falony & E, 2016. "Human gut microbes impact host serum metabolome and insulin sensitivity," Nature, Nature, vol. 535(7612), pages 376-381, July.
    2. Lisa Maier & Mihaela Pruteanu & Michael Kuhn & Georg Zeller & Anja Telzerow & Exene Erin Anderson & Ana Rita Brochado & Keith Conrad Fernandez & Hitomi Dose & Hirotada Mori & Kiran Raosaheb Patil & Pe, 2018. "Extensive impact of non-antibiotic drugs on human gut bacteria," Nature, Nature, vol. 555(7698), pages 623-628, March.
    3. Didier Ndeh & Artur Rogowski & Alan Cartmell & Ana S. Luis & Arnaud Baslé & Joseph Gray & Immacolata Venditto & Jonathon Briggs & Xiaoyang Zhang & Aurore Labourel & Nicolas Terrapon & Fanny Buffetto &, 2017. "Correction: Corrigendum: Complex pectin metabolism by gut bacteria reveals novel catalytic functions," Nature, Nature, vol. 548(7669), pages 612-612, August.
    4. Didier Ndeh & Artur Rogowski & Alan Cartmell & Ana S. Luis & Arnaud Baslé & Joseph Gray & Immacolata Venditto & Jonathon Briggs & Xiaoyang Zhang & Aurore Labourel & Nicolas Terrapon & Fanny Buffetto &, 2017. "Complex pectin metabolism by gut bacteria reveals novel catalytic functions," Nature, Nature, vol. 544(7648), pages 65-70, April.
    5. Koji Hosomi & Mayu Saito & Jonguk Park & Haruka Murakami & Naoko Shibata & Masahiro Ando & Takahiro Nagatake & Kana Konishi & Harumi Ohno & Kumpei Tanisawa & Attayeb Mohsen & Yi-An Chen & Hitoshi Kawa, 2022. "Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
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